Chinese General Practice ›› 2022, Vol. 25 ›› Issue (12): 1475-1481.DOI: 10.12114/j.issn.1007-9572.2021.02.101
Special Issue: 神经系统疾病最新文章合集
• Original Research·Characteristic Therapy of TCM • Previous Articles Next Articles
Received:
2021-07-20
Revised:
2021-10-09
Published:
2022-02-17
Online:
2022-03-21
Contact:
Yi DING
About author:
通讯作者:
丁懿
作者简介:
基金资助:
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URL: https://www.chinagp.net/EN/10.12114/j.issn.1007-9572.2021.02.101
组别 | 例数 | 性别(男/女) | 年龄(岁) | 病程(周) | 脑卒中性质(脑梗死/脑出血) |
---|---|---|---|---|---|
对照组 | 45 | 21/24 | 59.5±11.9 | 10.68±5.82 | 20/25 |
试验组 | 45 | 23/22 | 60.1±10.8 | 10.04±8.46 | 24/21 |
χ2(t)值 | 0.18 | -0.25a | 0.42a | 0.71 | |
P值 | 0.67 | 0.80 | 0.68 | 0.40 |
Table 1 Comparison of demographic data between two groups of post-stroke insomnia patients
组别 | 例数 | 性别(男/女) | 年龄(岁) | 病程(周) | 脑卒中性质(脑梗死/脑出血) |
---|---|---|---|---|---|
对照组 | 45 | 21/24 | 59.5±11.9 | 10.68±5.82 | 20/25 |
试验组 | 45 | 23/22 | 60.1±10.8 | 10.04±8.46 | 24/21 |
χ2(t)值 | 0.18 | -0.25a | 0.42a | 0.71 | |
P值 | 0.67 | 0.80 | 0.68 | 0.40 |
组别 | 例数 | 治愈 | 显效 | 有效 | 无效 |
---|---|---|---|---|---|
对照组 | 45 | 22(48.9) | 11(24.4) | 7(15.6) | 5(11.1) |
试验组 | 45 | 23(51.1) | 11(26.7) | 7(17.7) | 4(4.5) |
Table 2 Comparison of overall clinical efficacy between two groups of post-stroke insomnia patients
组别 | 例数 | 治愈 | 显效 | 有效 | 无效 |
---|---|---|---|---|---|
对照组 | 45 | 22(48.9) | 11(24.4) | 7(15.6) | 5(11.1) |
试验组 | 45 | 23(51.1) | 11(26.7) | 7(17.7) | 4(4.5) |
组别 | 例数 | 治疗前 | 治疗后 | 治疗前后评分差值 | t配对值 | P值 |
---|---|---|---|---|---|---|
对照组 | 45 | 12.9±2.1 | 6.9±1.6 | 5.9±2.2 | 41.01 | <0.01 |
试验组 | 45 | 12.7±2.0 | 6.8±1.0 | 6.0±1.7 | 35.86 | <0.01 |
t值 | 0.46 | 0.36 | -0.24 | |||
P值 | 0.64 | 0.72 | 0.81 |
Table 3 Comparison of PSQI scores between two groups of post-stroke insomnia patients before and after treatment
组别 | 例数 | 治疗前 | 治疗后 | 治疗前后评分差值 | t配对值 | P值 |
---|---|---|---|---|---|---|
对照组 | 45 | 12.9±2.1 | 6.9±1.6 | 5.9±2.2 | 41.01 | <0.01 |
试验组 | 45 | 12.7±2.0 | 6.8±1.0 | 6.0±1.7 | 35.86 | <0.01 |
t值 | 0.46 | 0.36 | -0.24 | |||
P值 | 0.64 | 0.72 | 0.81 |
组别 | 例数 | 治疗前 | 治疗后 | 治疗前后评分差值 | t配对值 | P值 |
---|---|---|---|---|---|---|
对照组 | 45 | 151.0±35.9 | 172.2±35.9 | 21.2±9.6 | -39.38 | <0.01 |
试验组 | 45 | 151.0±24.3 | 176.1±19.3 | 25.2±10.8 | -33.44 | <0.01 |
t值 | <0.01 | -0.64 | -1.86 | |||
P值 | >0.05 | 0.52 | 0.07 |
Table 4 Comparison of SS-QOL score between two groups of post-stroke insomnia patients before and after treatment
组别 | 例数 | 治疗前 | 治疗后 | 治疗前后评分差值 | t配对值 | P值 |
---|---|---|---|---|---|---|
对照组 | 45 | 151.0±35.9 | 172.2±35.9 | 21.2±9.6 | -39.38 | <0.01 |
试验组 | 45 | 151.0±24.3 | 176.1±19.3 | 25.2±10.8 | -33.44 | <0.01 |
t值 | <0.01 | -0.64 | -1.86 | |||
P值 | >0.05 | 0.52 | 0.07 |
组别 | 例数 | 治疗前 | 治疗后 | 治疗前后评分差值 | t配对值 | P值 |
---|---|---|---|---|---|---|
对照组 | 45 | 44.6±16.2 | 54.6±17.0 | 10.0±3.1 | -24.26 | <0.01 |
试验组 | 45 | 44.2±24.6 | 56.0±23.7 | 11.8±4.9 | -17.39 | <0.01 |
t值 | 0.09 | -0.32 | -2.22 | |||
P值 | 0.93 | 0.75 | 0.03 |
Table 5 Comparison of Fugl-Meyer scores between two groups of post-stroke insomnia patients before and after treatment
组别 | 例数 | 治疗前 | 治疗后 | 治疗前后评分差值 | t配对值 | P值 |
---|---|---|---|---|---|---|
对照组 | 45 | 44.6±16.2 | 54.6±17.0 | 10.0±3.1 | -24.26 | <0.01 |
试验组 | 45 | 44.2±24.6 | 56.0±23.7 | 11.8±4.9 | -17.39 | <0.01 |
t值 | 0.09 | -0.32 | -2.22 | |||
P值 | 0.93 | 0.75 | 0.03 |
组别 | 例数 | 5-HT(μg/L) | MT(ng/L) | NE(μmol/L) | |||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
治疗前 | 治疗后 | t配对值 | P值 | 治疗前 | 治疗后 | t配对值 | P值 | 治疗前 | 治疗后 | t配对值 | P值 | ||
对照组 | 45 | 73.48±13.26 | 96.73±12.88 | -19.82 | <0.01 | 2.23±0.73 | 2.87±0.74 | -9.26 | <0.01 | 4.64±0.24 | 3.19±0.30 | 34.72 | <0.01 |
试验组 | 45 | 73.10±13.80 | 97.33±12.17 | -15.98 | <0.01 | 2.17±0.60 | 2.94±0.77 | -7.88 | <0.01 | 4.79±0.33 | 3.25±0.28 | 42.29 | <0.01 |
t值 | 0.24 | 0.43 | 0.67 | 0.81 | -1.95 | -1.75 | |||||||
P值 | 0.81 | 0.67 | 0.50 | 0.92 | 0.05 | 0.08 |
Table 6 Comparison of serum 5-HT,melatonin and norepinephrine levels between two groups of post-stroke insomnia patients before and after treatment
组别 | 例数 | 5-HT(μg/L) | MT(ng/L) | NE(μmol/L) | |||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
治疗前 | 治疗后 | t配对值 | P值 | 治疗前 | 治疗后 | t配对值 | P值 | 治疗前 | 治疗后 | t配对值 | P值 | ||
对照组 | 45 | 73.48±13.26 | 96.73±12.88 | -19.82 | <0.01 | 2.23±0.73 | 2.87±0.74 | -9.26 | <0.01 | 4.64±0.24 | 3.19±0.30 | 34.72 | <0.01 |
试验组 | 45 | 73.10±13.80 | 97.33±12.17 | -15.98 | <0.01 | 2.17±0.60 | 2.94±0.77 | -7.88 | <0.01 | 4.79±0.33 | 3.25±0.28 | 42.29 | <0.01 |
t值 | 0.24 | 0.43 | 0.67 | 0.81 | -1.95 | -1.75 | |||||||
P值 | 0.81 | 0.67 | 0.50 | 0.92 | 0.05 | 0.08 |
[1] |
|
[2] |
|
[3] |
李泰标. 针刺治疗脑卒中后失眠疗效观察[J]. 中国康复理论与实践,2007,13(7):656-657.
|
[4] |
|
[5] |
中华医学会神经病学分会,中华医学会神经病学分会睡眠障碍学组. 中国成人失眠诊断与治疗指南(2017版)[J]. 中华神经科杂志,2018,51(5):324-335. DOI:10.3760/cma.j.issn.1006-7876.2018.05.002.
|
[6] |
|
[7] |
|
[8] |
中华医学会神经病学分会,中华医学会神经病学分会脑血管病学组. 中国急性缺血性脑卒中诊治指南(2018)[J]. 中华神经科杂志,2018,51(9):666-682. DOI:10.3760/cma.j.issn.1006-7876.2018.09.004.
|
[9] |
中华医学会神经病学分会,中华医学会神经病学分会脑血管病学组. 中国脑出血诊治指南(2019)[J]. 中华神经科杂志,2019,52(12):994-1005. DOI:10.3760/cma.j.issn.1006-7876.2019.12.003.
|
[10] |
American Academy of Sleep Medicine. International classification of sleep disorders,3rd edition[M]. Darien IL:American Academy of Sleep Medicine,2014.
|
[11] |
国家中医药管理局. 中医病证诊断疗效标准[S]. 北京:国家中医药管理局,1994.
|
[12] |
中华医学会神经病学分会,中华医学会神经病学分会神经康复学组,中华医学会神经病学分会脑血管病学组.中国脑卒中早期康复治疗指南[J].中华神经科杂志,2017,50(6):405-412. DOI:10.3760/cma.j.issn.1006-7876.2017.06.002.
|
[13] |
|
[14] |
刘志喜,石倩萍,杨洪霞,等. 匹兹堡睡眠质量指数量表在护理人群中的信效度评价[J]. 汕头大学医学院学报,2020,33(3):173-176. DOI:10.13401/j.cnki.jsumc.2020.03.011.
|
[15] |
|
[16] |
李军涛,王伊龙,于进洪,等. 脑卒中专门化生存质量量表(SS-QOL)中译本在冀南地区效度的研究[J]. 脑与神经疾病杂志,2007,15(3):177-179.
|
[17] |
|
[18] |
中华人民共和国卫生部. 中药新药临床研究指导原则[S]. 北京:中华人民共和国卫生部,1993:186-188.
|
[19] |
|
[20] |
|
[21] |
|
[22] |
吴文忠,郑诗雨,刘成勇,等. "通督调神"针刺治疗慢性失眠症及对血清GABA及CORT水平的影响[J]. 中国针灸,2021,41(7):721-724. DOI:10.13703/j.0255-2930.20200704-k0001.
|
[23] |
王淑兰,倪光夏. 针刺督脉经穴对局灶性脑缺血再灌注大鼠缺血半暗带MAP-2、NF-L的mRNA表达的影响[J]. 上海针灸杂志,2013,32(3):221-223.
|
[24] |
|
[25] |
|
[26] |
罗本华,王燕,张亚飞,等. 三种针法对对氯苯丙氨酸诱导失眠大鼠海马5-HT1A、5-HT2A基因表达影响研究[J]. 中华中医药学刊,2017,35(10):2630-2633. DOI:10.13193/j.issn.1673-7717.2017.10.041.
|
[27] |
王晓秋,秦珊,吴文忠,等. 电针治疗老年失眠症及对血清褪黑素和多巴胺的影响[J]. 中国针灸,2021,41(5):501-504. DOI:10.13703/j.0255-2930.20200404-k0001.
|
[28] |
陈宁贵,廖敏. 解郁丸联合西酞普兰治疗难治性抑郁症的疗效及其对血清去甲肾上腺素和5-羟色胺及脑源性神经营养因子指标的影响研究[J]. 中国全科医学,2017,20(S2):338-340.
|
[29] |
|
[30] |
胡亮,韩雨晴. 运动抗抑郁的神经生物学机制研究新进展[J]. 陕西师范大学学报(自然科学版),2019,47(3):9-20. DOI:10.15983/j.cnki.jsnu.2019.03.232.
|
[31] |
|
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