Chinese General Practice ›› 2021, Vol. 24 ›› Issue (36): 4640-4647.DOI: 10.12114/j.issn.1007-9572.2021.02.062
Special Issue: 中医最新文章合集; 神经退行性病变最新文章合集; 阿尔茨海默病最新文章合集; 阿尔茨海默病最新文章合集
• Monographic Research • Previous Articles Next Articles
Published:
2021-12-20
Online:
2021-12-01
基金资助:
LUO Meng,GAO Jing,DUAN Zhaoyuan,LIU Chengmei,LI Ruiqing,SU Kaiqi,CHEN Zhuo,FENG Xiaodong. Advances in the Mechanism of Chinese Medicine Targeting NF-κB Signaling Pathway in the Prevention and Treatment of Cognitive Impairment [J]. Chinese General Practice, 2021, 24(36): 4640-4647.
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URL: https://www.chinagp.net/EN/10.12114/j.issn.1007-9572.2021.02.062
中药复方 | 成分 | 功效 | 效应分子 |
---|---|---|---|
丹左合方 | 柴胡、白芍、当归、丹皮、栀子、白术、茯苓、甘草、黄连、吴茱萸 | 疏肝解郁、清热泻火、健脾养血 | CRP、iNOS、IL-6、COX-2、NF-κB |
加味不忘散 | 远志、石菖蒲、人参、茯神、茯苓、熟地黄、当归、熟白术、黄连 | 补肾填精、养血活血、益气健脾、燥湿化痰、清热解毒 | TNF-α、NF-κB p65 |
地黄饮子 | 熟地、五味子、巴戟天、石斛、麦冬、远志、山茱萸、肉苁蓉、附子、肉桂、蒲、薄荷、生姜、大枣 | 滋肾阴、补肾阳、开窍化痰 | TNF-α、IL-1β、NF-κB pp65 |
改良三甲散 | 鳖甲、龟甲、地鳖虫、地龙、石菖蒲、何首乌 | 滋补肾精、活血祛瘀、化痰开窍 | ChAT、TChE、LDH、NF-κB、JNK |
黄连解毒汤 | 黄连、黄柏、黄芩、栀子 | 清热解毒 | SOD、MDA、IκB、NF-κB |
参蓉胶囊 | 人参、肉苁蓉等 | 补肾壮阳、强筋壮骨 | Caspase-3、IκB-α、NF-κB p65 |
醒脑静注射液 | 麝香、冰片等 | 开窍活血、清热醒神 | TNF-α、IL-1β、IL-6、TLR4、NF-κB、IκB-α |
酸枣仁汤 | 炒酸枣仁、茯苓、知母、川芎、炙甘草 | 养血安神、清热除烦 | TLR4、NF-κB p65、IκB-α |
加味脑泰方 | 黄芪、川芎、地龙、当归、石菖蒲、三七、远志 | 益气活血、化痰祛瘀 | SIRT1、NF-κB、IκB-α |
当归芍药散 | 当归、白芍、茯苓、白术、泽泻、川芎 | 养血调肝、健脾利湿 | TNF-α、IL-1β、NF-κB、p-NF-κB、Iba-1、PI3K、AKT、p-AKT、LC3-Ⅱ/LC3-Ⅰ、GFAP、ERs(ERα和ERβ)、NLRP3、Caspase-1、ASC |
安宫牛黄丸 | 牛黄、郁金、犀角、黄连、朱砂、栀子、雄黄、黄芩、珍珠、冰片、麝香 | 开窍醒脑、止痉定惊 | VEGF、SOD、MDA、NF-κB |
加减薯蓣丸 | 山药、熟地、制首乌、党参、白芍、当归、炒白术、茯苓、枸杞、石菖蒲、远志、杜仲、川芎、五味子 | 健脾益肾、化痰祛瘀、开窍益智 | IL-1β、NF-κB、miR-146a |
Table 1 The effects of compound preparations of Chinese medicine on the regulation of NF-κB signalingpathway in cognitive impairment
中药复方 | 成分 | 功效 | 效应分子 |
---|---|---|---|
丹左合方 | 柴胡、白芍、当归、丹皮、栀子、白术、茯苓、甘草、黄连、吴茱萸 | 疏肝解郁、清热泻火、健脾养血 | CRP、iNOS、IL-6、COX-2、NF-κB |
加味不忘散 | 远志、石菖蒲、人参、茯神、茯苓、熟地黄、当归、熟白术、黄连 | 补肾填精、养血活血、益气健脾、燥湿化痰、清热解毒 | TNF-α、NF-κB p65 |
地黄饮子 | 熟地、五味子、巴戟天、石斛、麦冬、远志、山茱萸、肉苁蓉、附子、肉桂、蒲、薄荷、生姜、大枣 | 滋肾阴、补肾阳、开窍化痰 | TNF-α、IL-1β、NF-κB pp65 |
改良三甲散 | 鳖甲、龟甲、地鳖虫、地龙、石菖蒲、何首乌 | 滋补肾精、活血祛瘀、化痰开窍 | ChAT、TChE、LDH、NF-κB、JNK |
黄连解毒汤 | 黄连、黄柏、黄芩、栀子 | 清热解毒 | SOD、MDA、IκB、NF-κB |
参蓉胶囊 | 人参、肉苁蓉等 | 补肾壮阳、强筋壮骨 | Caspase-3、IκB-α、NF-κB p65 |
醒脑静注射液 | 麝香、冰片等 | 开窍活血、清热醒神 | TNF-α、IL-1β、IL-6、TLR4、NF-κB、IκB-α |
酸枣仁汤 | 炒酸枣仁、茯苓、知母、川芎、炙甘草 | 养血安神、清热除烦 | TLR4、NF-κB p65、IκB-α |
加味脑泰方 | 黄芪、川芎、地龙、当归、石菖蒲、三七、远志 | 益气活血、化痰祛瘀 | SIRT1、NF-κB、IκB-α |
当归芍药散 | 当归、白芍、茯苓、白术、泽泻、川芎 | 养血调肝、健脾利湿 | TNF-α、IL-1β、NF-κB、p-NF-κB、Iba-1、PI3K、AKT、p-AKT、LC3-Ⅱ/LC3-Ⅰ、GFAP、ERs(ERα和ERβ)、NLRP3、Caspase-1、ASC |
安宫牛黄丸 | 牛黄、郁金、犀角、黄连、朱砂、栀子、雄黄、黄芩、珍珠、冰片、麝香 | 开窍醒脑、止痉定惊 | VEGF、SOD、MDA、NF-κB |
加减薯蓣丸 | 山药、熟地、制首乌、党参、白芍、当归、炒白术、茯苓、枸杞、石菖蒲、远志、杜仲、川芎、五味子 | 健脾益肾、化痰祛瘀、开窍益智 | IL-1β、NF-κB、miR-146a |
中药单体或有效成分 | 功效 | 效应分子 |
---|---|---|
栀子 | 泻火除烦、清热 | IL-1β、IL-6、TNF-α、TLR4、NF-κB p65 |
通天草 | 清热解毒、利尿、降逆 | IκB-α、NF-κB、Caspase-3 |
冬凌草 | 清热解毒、消炎止痛 | IL-1β、IL-6、iNOS、TNF-ɑ、COX-2、p-IκB、IκB-ɑ、NF-κB p65 |
鬼针草 | 清热解毒、散瘀消肿 | BDNF、IL-1β、IL-6、TNF-α、p-NF-κB p65 |
叶下珠 | 解毒、消炎、清热止泻、利尿 | IL-1β、TNF-α、p-IκB-α、p-NF-κB |
积雪草 | 清热利湿、解毒消肿 | TLR4、MyD88、TRAF6、TNF-α、IL-6、p-NF-κB p65 |
金线莲 | 清热凉血、祛风利湿 | SOD、MDA、p-NF-κB p65 |
三七 | 活血化瘀、消肿定痛 | NF-κB p50 |
红景天 | 益气活血、通脉平喘 | MAO、MDA、SOD、Ach、Ach E、iNOS、RAGE、NF-κB |
姜黄 | 行气破瘀、通经止痛 | TNF-α、IL-6、IL-1β、SOD、MDA、Bcl-2、Bax、SIRT1、Ac-FOXO1、Ac-NF-κB、NF-κB |
雷公藤 | 祛风除湿、活血通络、消肿止痛、杀虫解毒 | IL-6、SOD、MDA、SIRT1、IκB-α、NF-κB、Caspase-3 |
五味子 | 收敛固涩、益气生津、补肾宁心 | iNOS、ROS、pp65、NF-κB |
蛇床子 | 燥湿祛风、杀虫止痒、温肾壮阳 | TLR4、TRAF6、NF-κB |
芝麻酚 | 补肝肾、益精血、润肠燥、通乳 | ROS、iNOS、COX-2、IL-1β、TNF-α、Ach、ERK、JNK、p38、NF-κB |
蓝布正 | 益气健脾、补血养阴、润肺化痰 | PI3K、IκB-α、IKK-α、NF-κB p65 |
葛根 | 解肌退热、透疹、生津止渴、升阳止泻 | HMGB1、RAGE、p-NF-κB p65、p-IκB-α |
升麻 | 发表透疹、清热解毒、升举阳气 | NFκB p-p65、NFκB p65 |
黄芪 | 补气升阳、固表止汗、利水消肿、生津止血、行滞通痹 | IκB-α、IκB-α、NF-κB、Caspase-3 |
火麻仁 | 润肠通便 | TNF-α、IL-1β、GFAP、p-IKK、p-IκB、pp65 |
旋覆花 | 降气、消痰、行水、止呕 | iNOS、COX-2、PPARγ、Bax、NF-κB、Caspase-3 |
Table 2 The effects of single preparation of Chinese medicine and its effective ingredients on the regulation of NF-κB signaling pathway in cognitive impairment
中药单体或有效成分 | 功效 | 效应分子 |
---|---|---|
栀子 | 泻火除烦、清热 | IL-1β、IL-6、TNF-α、TLR4、NF-κB p65 |
通天草 | 清热解毒、利尿、降逆 | IκB-α、NF-κB、Caspase-3 |
冬凌草 | 清热解毒、消炎止痛 | IL-1β、IL-6、iNOS、TNF-ɑ、COX-2、p-IκB、IκB-ɑ、NF-κB p65 |
鬼针草 | 清热解毒、散瘀消肿 | BDNF、IL-1β、IL-6、TNF-α、p-NF-κB p65 |
叶下珠 | 解毒、消炎、清热止泻、利尿 | IL-1β、TNF-α、p-IκB-α、p-NF-κB |
积雪草 | 清热利湿、解毒消肿 | TLR4、MyD88、TRAF6、TNF-α、IL-6、p-NF-κB p65 |
金线莲 | 清热凉血、祛风利湿 | SOD、MDA、p-NF-κB p65 |
三七 | 活血化瘀、消肿定痛 | NF-κB p50 |
红景天 | 益气活血、通脉平喘 | MAO、MDA、SOD、Ach、Ach E、iNOS、RAGE、NF-κB |
姜黄 | 行气破瘀、通经止痛 | TNF-α、IL-6、IL-1β、SOD、MDA、Bcl-2、Bax、SIRT1、Ac-FOXO1、Ac-NF-κB、NF-κB |
雷公藤 | 祛风除湿、活血通络、消肿止痛、杀虫解毒 | IL-6、SOD、MDA、SIRT1、IκB-α、NF-κB、Caspase-3 |
五味子 | 收敛固涩、益气生津、补肾宁心 | iNOS、ROS、pp65、NF-κB |
蛇床子 | 燥湿祛风、杀虫止痒、温肾壮阳 | TLR4、TRAF6、NF-κB |
芝麻酚 | 补肝肾、益精血、润肠燥、通乳 | ROS、iNOS、COX-2、IL-1β、TNF-α、Ach、ERK、JNK、p38、NF-κB |
蓝布正 | 益气健脾、补血养阴、润肺化痰 | PI3K、IκB-α、IKK-α、NF-κB p65 |
葛根 | 解肌退热、透疹、生津止渴、升阳止泻 | HMGB1、RAGE、p-NF-κB p65、p-IκB-α |
升麻 | 发表透疹、清热解毒、升举阳气 | NFκB p-p65、NFκB p65 |
黄芪 | 补气升阳、固表止汗、利水消肿、生津止血、行滞通痹 | IκB-α、IκB-α、NF-κB、Caspase-3 |
火麻仁 | 润肠通便 | TNF-α、IL-1β、GFAP、p-IKK、p-IκB、pp65 |
旋覆花 | 降气、消痰、行水、止呕 | iNOS、COX-2、PPARγ、Bax、NF-κB、Caspase-3 |
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