Recent Developments in Amyotrophic Lateral Sclerosis and Cholesterol Metabolism

doi:10.12114/j.issn.1007-9572.2018.00.344

Abstract

Abstract: Amyotrophic lateral sclerosis is a degenerative disease of the nervous system.Its pathogenesis is not clear and there is no effective treatment.Cholesterol is a main component of the cell membrane，which is vital to the maintenance of the normal function of the cell.The brain is the most cholesterol-rich organ in human body.In recent years，the studies of abnormal brain cholesterol metabolism and neurodegenerative diseases are increasing.This article elaborates the relationship between cholesterol metabolism and amyotrophic lateral sclerosis.

Key words: Amyotrophic lateral sclerosis, Cholesterol, Energy metabolism

摘要： 肌萎缩侧索硬化（ALS）是一种神经系统变性疾病，发病机制尚不清楚，尚无有效的治疗方法。胆固醇是构成细胞膜的主要成分，对维持细胞的正常功能至关重要，脑是人体胆固醇含量最丰富的器官。近年来关于脑胆固醇代谢异常与神经系统变性疾病的研究逐渐增多，本文主要阐述ALS与胆固醇代谢的相关性。

关键词: 肌萎缩侧索硬化, 胆固醇, 能量代谢

ZHOU Xiaomeng,CAO Cuifang,LIU Yaling, et al. Recent Developments in Amyotrophic Lateral Sclerosis and Cholesterol Metabolism　[J]. Chinese General Practice, 2019, 22(18): 2257-2261. DOI: 10.12114/j.issn.1007-9572.2018.00.344.
周晓萌,曹翠芳,刘亚玲等. 肌萎缩侧索硬化与胆固醇代谢的相关性研究进展[J]. 中国全科医学, 2019, 22(18): 2257-2261. DOI: 10.12114/j.issn.1007-9572.2018.00.344.

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