Abstract: Background　The diagnosis of sleep disorders has been lack of objective indicators and basis. It usually relies on patients ' subjective expression and traditional evaluation scale to diagnose sleep disorders. It is often affected by patients' psychological state and subjective assumptions, which reduces the accuracy of clinical diagnosis. In recent years, many studies have shown that sleep disorders are correlated with vitamin D levels, but some studies have found that there is no relationship between them, and it is necessary to systematically evaluate the correlation between sleep disorders and vitamin D levels. Objective　To explore the correlation between sleep disorders and vitamin D deficiency from the perspective of evidence-based medicine.Methods　From November 2017 to February 2018， we searched CBM， CNKI， Wanfang Data Knowledge Service Platform， VIP， Medline， EMBase， Web of Science， Cochrane Library （Issue 2，2018） until February 2018 to identify articles evaluating the correlation between sleep disorder and vitamin D deficiency.Data extraction and quality assessment were conducted.Results　A total of 15 articles were included， involving a sample of 15 622 individuals.Meta-analysis showed that sleep disorders were associated with vitamin D deficiency〔RR=1.20， 95%CI（1.03，1.39）， P=0.02〕.Subgroup analysis showed the following results： sleep disorders were associated with vitamin D deficiency in the Mongolian and Negroe populations（P<0.05）， but not in the European populations （P>0.05）； sleep disorders were associated with vitamin D deficiency in the Asian population（P<0.05）；two types of sleep disorders， sleep debt and obstructive sleep apnea hypopnea syndrome were associated with vitamin D deficiency（P<0.05）； sleep disorders diagnosed by PSG were associated with vitamin D deficiency （P<0.05）， but those diagnosed by PSQI and ESS were not （P>0.05）； sleep disorders were associated with vitamin D deficiency in the population consisting of both males and females （P<0.05）， but were not in female population （P>0.05）； sleep disorders were found to be associated with vitamin D deficiency measured by immunoassay（P<0.05）．Conclusion　There is a correlation between sleep disorders and vitamin D deficiency， which varies by race，areas，types of sleep disorders，diagnostic methods of sleep disorders，detection methods of vitamin D and other factors.

Key words: Sleep disorders, Vitamin D deficiency, Meta-analysis

摘要： 背景　睡眠障碍的诊断一直缺乏较为客观的指标和依据，通常依靠患者的主观表述和传统的评估量表进行诊断，常受到患者的心理状态和主观臆断的影响，降低了临床诊断的准确性。近年来，国内外多项研究表明，睡眠障碍与维生素D水平具有相关性，但也有研究认为，二者之间无必然联系，需要系统评价睡眠障碍与维生素D水平相关性。目的　采用循证医学的方法，探讨睡眠障碍与维生素D不足的相关性。方法　2017年11月—2018年2月，计算机检索中国生物医学文献数据库（CBM）、中国知网（CNKI）、万方数据知识服务平台、维普科技期刊数据库（VIP）、Medline、EMBase、Web of Science、Cochrane Library（2018年第2期），检索时间为建库至2018年2月。获取睡眠障碍与维生素D不足相关性的文献，提取文献数据并评价文献质量。结果　共纳入15篇文献，样本总量为15 622例。Meta分析结果显示，睡眠障碍与维生素D不足有关〔RR=1.20， 95%CI（1.03，1.39）， P=0.02〕。亚组分析显示，在以蒙古人种、尼各罗人种为研究人群的亚组中，睡眠障碍与维生素D不足有关（P<0.05），而在以欧罗巴人种为研究人群的亚组中，睡眠障碍与维生素D不足无关（P>0.05）；在以亚洲研究人群的亚组中，睡眠障碍与维生素D不足有关（P<0.05）；在不同的睡眠障碍类型亚组中，睡眠不足、阻塞性睡眠呼吸暂停低通气综合征（OSAHS）与维生素D不足有关（P<0.05）；在采用匹兹堡睡眠质量指数量表（PSQI）、Epworth嗜睡量表（ESS）诊断睡眠障碍的亚组中，睡眠障碍与维生素D不足无关（P>0.05），而采用多导睡眠监测仪（PSG）诊断睡眠障碍的亚组中，睡眠障碍与维生素D不足有关（P<0.05）；在单纯以女性为研究对象的亚组中，睡眠障碍与维生素D不足无关（P>0.05），而研究对象中均有男女时，睡眠障碍与维生素D不足有关（P<0.05）；采用免疫分析法检测维生素D水平的亚组，睡眠障碍与维生素D不足有关（P<0.05）。结论　睡眠障碍与维生素D不足存在相关性，且存在种族、地区等差异，同时与睡眠障碍类型及诊断方法、维生素D检测方法相关。

关键词: 睡眠障碍, 维生素D缺乏, Meta分析