The accelerations of globalization, climate change, and population aging gradually increase the complex challenges to human health. Globalization-induced global health issues significantly increase the speed and range of infectious disease transmission, causing a more profound impact. Climate change not only directly affects human health but also indirectly increases the risk of infectious disease outbreaks by altering ecosystems and the distribution of disease vectors. Meanwhile, population aging has escalated the burden of chronic non-infectious diseases and highlighted complex health issues like comorbidities, posing significant challenges to healthcare systems and social service assurance systems. Technological innovations offer unprecedented opportunities to address these health challenges. Advanced techniques like precision medicine and artificial intelligence (AI) are emerging innovations to deal with current health issues. Advancements in technology are reshaping our health management paradigms. Technological innovations are not only the driving forces for the development of modern medicine, but also the key to addressing future health issues. In the future, it is essential to strengthen health system construction, innovate mechanisms for medical and preventive integration, enhance scientific and technological research and innovation, and empower primary healthcare with AI, aiming to further tackle health challenges and improve human well-being.