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           [47]PRINZ M,JUNG S,PRILLER J. Microglia biology:one century of   10.1186/s12974-019-1552-y.
               evolving concepts[J]. Cell,2019,179(2):292-311. DOI:  [54]KOSZEWICZ M,JAROCH J,BRZECKA A,et al. Dysbiosis
               10.1016/j.cell.2019.08.053.                          is one of the risk factor for stroke and cognitive impairment and
           [48]LUU M,PAUTZ S,KOHL V,et al. The short-chain fatty acid   potential target for treatment[J]. Pharmacol Re,2020,164:
               pentanoate suppresses autoimmunity by modulating the metabolic-  105277. DOI:10.1016/j.phrs.2020.105277.
               epigenetic crosstalk in lymphocytes[J]. Nat Commun,2019,10  [55]LIU Y,KONG C,GONG L,et al. The association of post-stroke
               (1):760. DOI:10.1038/s41467-019-08711-2.             cognitive impairment and gut microbiota and its corresponding
           [49]ÍÑIGUEZ-GUTIÉRREZ L,GODÍNEZ-MÉNDEZ L A,FAFUTIS-      metabolites[J]. J Alzheimers Dis,2020,73(4):1455-1466.
               MORRIS M,et al. Physiological concentrations of short-chain   DOI:10.3233/JAD-191066.
               fatty acids induce the formation of neutrophil extracellular traps   [56]ZHOU Z,XU N,MATEI N,et al. Sodium butyrate attenuated
               in vitro[J]. Int J Immunopathol Pharmacol,2020,34:   neuronal apoptosis via GPR41/Gβγ/PI3K/Akt pathway after MCAO
               2058738420958949. DOI:10.1177/2058738420958949.      in rats[J]. J Cereb Blood Flow Metab,2021,41(2):267-
           [50]KOBAYASHI M,MIKAMI D,KIMURA H,et al. Short-chain     281. DOI:10.1177/0271678X20910533.
               fatty acids,GPR41 and GPR43 ligands,inhibit TNF-α-induced   [57]YANG W,YU T,HUANG X,et al. Intestinal microbiota-derived
               MCP-1 expression by modulating p38 and JNK signaling pathways   short-chain fatty acids regulation of immune cell IL-22 production
               in human renal cortical epithelial cells[J]. Biochem Biophys   and gut immunity[J]. Nat Commun,2020,11(1):4457.
               Res Commun,2017,486(2):499-505. DOI:10.1016/j.       DOI:10.1038/s41467-020-18262-6.
               bbrc.2017.03.071.                               [58]SADLER R,CRAMER J V,HEINDL S,et al. Short-chain
           [51]SMITH  M  D,BHATT  D  P,GEIGER  J  D,et  al.  Acetate   fatty  acids  improve  poststroke  recovery  via  immunological
               supplementation  modulates  brain  adenosine  metabolizing   mechanisms[J]. J Neurosci,2020,40(5):1162-1173.
               enzymes and adenosine A2A receptor levels in rats subjected to   DOI:10.1523/JNEUROSCI.1359-19.2019.
               neuroinflammation[J]. J Neuroinflammation,2014,11:99.   [59]CSERÉP C,PÓSFAI B,LÉNÁRT N,et al. Microglia monitor and
               DOI:10.1186/1742-2094-11-99.                         protect neuronal function through specialized somatic purinergic
           [52]LIU J,LI H,GONG T,et al. Anti-neuroinflammatory effect   junctions[J]. Science,2020,367(6477):528-537. DOI:
               of short-chain fatty acid acetate against Alzheimer's disease via   10.1126/science.aax6752.
               upregulating GPR41 and inhibiting ERK/JNK/NF-κB[J]. J Agric   [60]LI J M,YU R,ZHANG L P,et al. Dietary fructose-induced
               Food Chem,2020,68(7):7152-7161. DOI:10.1021/acs.     gut dysbiosis promotes mouse hippocampal neuroinflammation:
               jafc.0c02807.                                        a benefit of short-chain fatty acids[J]. Microbiome,2019,7(1):
           [53]CH EN  T ,NOT O  D,H OSH INO  Y,et  al.  Butyrate    98. DOI:10.1186/s40168-019-0713-7.
               suppresses demyelination and enhances remyelination[J].    (收稿日期:2021-03-01;修回日期:2021-06-22)
               J  Neuroinflammation,2019,16(1):165.  DOI;                                      (本文编辑:鹿飞飞)





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           《中国全科医学》脑健康系列研究栏目征稿


              “脑健康”的范围比较广,除了常见的脑血管疾病、脑炎、脑肿瘤外,还包括睡眠障碍、精神障碍等脑功能性疾病。既往对于脑疾病的认
           识多停留在老年人脑疾病,如老年痴呆、脑出血、脑缺血及并发症等。随着社会发展,来自生活和工作多方面的压力及受不良生活方式的影响,
           使得脑疾病的发病逐渐年轻化,引发睡眠质量不佳、记忆力下降、头疼、精神紧张、情绪焦躁等一系列症状,尤其在
           年轻群体中高发。因此,《中国全科医学》开设“脑健康系列研究”专栏,针对此方向的最新研究成果进行报道,重
           点关注方向如下:“脑血管性疾病的防治”“脑病并发症及后遗症的康复”“体医融合——科学运动对脑健康的影响”“脑
           炎、癫痫的诊治”“头疼、睡眠障碍、精神障碍的诊治与健康管理”“认知障碍、记忆衰退、痴呆的防治与干预”。
           来稿形式不限,述评 / 综述、现况调查、随机对照研究、队列研究、质性研究等均可;要求观点鲜明、内容翔实、数
           据 / 证据充分,有一定的创新性和前沿性,能很好地反映临床难点和热点问题。
              投稿途径:请登录本刊官网 www.chinagp.net 进行在线投稿;投稿时文题前 +“脑健康系列研究”字样,如“脑健
           康系列研究”+ 文题。                                                                            扫描二维码
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