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    15 August 2023, Volume 26 Issue 23
    Guidelines Interpretation
    Screening Assessment and Therapy Intervention of Cancer Cachexia in Adult Patients——Based on the Interpretation of Cancer Cachexia in Adult Patients: ESMO Clinical Practice Guidelines
    WANG Rui, WANG Xiaomei, PENG Guoqing, YU Huan, WANG Sihan, XIA Jin
    2023, 26(23):  2823-2829.  DOI: 10.12114/j.issn.1007-9572.2023.0023
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    Cancer cachexia is a cancer-related, multi-factorial, irreversible clinical syndrome characterized by progressive nutritional consumption, which greatly reduces the survival expectation and quality of life of cancer patient. In 2010, the European Palliative Care Research Collaborative published the Clinical Practice Guideline on Cancer Cachexia in Advanced Cancer Patients, which based on clinical evidence, providing recommendations about cachexia classification and treatment in patients with advanced cancer. However, the guideline is mainly applicable to patients with advanced cancer who may present with refractory cachexia. Based on the continuously updated evidence, the European Society of Medical Oncology released the Cancer Cachexia in Adult Patients: ESMO Clinical Practice Guideline, which provides a more clear structural framework for the management of cancer cachexia, focusing on all cancer patient who may develop into cachexia, making recommendations in terms of screening, evaluation and multimodal management of cachexia. This paper interprets and summarizes the key points of the guideline in order to provide a reference for clinical management of cancer cachexia in China.

    A Newly Discovered Disease Affecting Women's Physical and Mental Health: Research Status and Expert Consensus Interpretation of Persistent Genital Arousal Disorder
    ZHANG Yunxu, WANG Tingting, WEI Junling, XING Yanyun, SU Li
    2023, 26(23):  2830-2835.  DOI: 10.12114/j.issn.1007-9572.2022.0815
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    Persistent genital arousal disorder (PGAD) and genito-pelvic dysesthesia (GPD) are jointly known as PGAD/GPD, which is a newly discovered condition in recent years, featured by spontaneous or secondary persistent genital arousal and/or dysesthesia in the genital and pelvic areas. PGAD/GPD mainly affects women, which can seriously influence the physical and mental health of the sufferers due to the specificity of its symptoms. Most patients have anxiety, depression, and even the suicidal tendency. The medical community abroad has paid attention to PGAD/GPD, and included it in the International Classification of Diseases-11th Revision (ICD-11) . Given the fact that this newly discovered condition is under-recognized among domestic health providers at present, we summarized the current research on PGAD/GPD abroad and introduced the epidemiological characteristics, pathophysiological mechanisms, diagnosis and treatment methods of PGAD/GPD based on the review of the latest expert consensus of the International Society for the Study of Women's Sexual Health (ISSWSH) , and discussed the future research direction of PGAD/GPD and the coping strategies that should be taken by the domestic medical community, with a view to arousing medical workers' attention to the disease in China.

    Standard Specifications
    Specification for Ovarian Tissue Cryopreservation and Transplantation
    Beijing Obstetrics and Gynecology Hospital,Capital Medical University, Committee of Fertility Protection and Preservation of China Association for the Promotion of Health Science and Technology
    2023, 26(23):  2836-2841.  DOI: 10.12114/j.issn.1007-9572.2023.0237
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    Original Research·Elderly Frailty Research
    Correlation between Nutrition-related Parameters and Frailty among Older Adults in the Emergency Department
    SHANG Na, WANG Na, LIU Huizhen, LIU Lushan, WANG Yahui, GUO Shubin
    2023, 26(23):  2842-2847.  DOI: 10.12114/j.issn.1007-9572.2022.0829
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    Background

    As an important modifiable factor that can be intervened, nutrition is closely related to the occurrence of frailty. Early identification of frailty through nutrition evaluation and reversal of its occurrence is of great significance for improving clinical outcomes. There are few available studies on the predictive value of nutrition-related parameters for frailty among older patients in the emergency department (ED) .

    Objective

    To evaluate the relationship between commonly used nutrition-related parameters and frailty among older adults in the ED.

    Methods

    Two hundred and ten people aged≥65 years were recruited from the Department of Emergency Medicine, China Rehabilitation Research Center (Beijing Bo'Ai Hospital) from January to October 2021. The demographic data were recorded. Fasting venous blood sample was collected within 24 hours after admission to measure routine indicators. The nutritional risk was assessed by Nutrition Risk Screening 2002 (NRS2002) . The basic activities of daily living were evaluated by Barthel Index (BI) . The Clinical Frailty Scale (CFS) was used to assess frailty, and individuals with CFS levels 1-4 (n=68) and those with CFS levels 5-9 (n=142) were assigned to non-frail group and frail group, respectively. Multivariable Logistic regression was used to analyze the factors associated with frailty in older patients in the ED. Hosmer-Lemeshow test and receiver operating characteristic (ROC) curve were used to evaluate the predictive validity of nutrition-related parameters for frailty in older patients in the ED. Nonparametric DeLong test was used to compare the area under the ROC curve (AUC) of each parameter.

    Results

    There were statistically significant differences between frail and non-frail patients in mean age, sex ratio, mean body mass index (BMI) , prevalence of coronary heart disease, mean levels of hemoglobin (HGB) , albumin (ALB) , prealbumin (PA) , high-sensitivity C-reactive protein (hs-CRP) and 25-hydroxyvitamin D〔25 (OH) D〕, and mean score of NRS2002, as well as mean BI and length of hospital stay (P<0.05) . Multivariable Logistic regression analysis showed that higher PA〔OR=0.943, 95%CI (0.891, 0.998) , P=0.041〕 and 25 (OH) D〔OR=0.909, 95%CI (0.844, 0.979) , P=0.012〕were protective factors of frailty in older patients in the ED. The risk of frailty decreased by 44.6% for every 100 mg/L increase in PA, and decreased by 61.7% for every 10 μg/L increase in 25 (OH) D. However, higher NRS2002 score〔OR=1.701, 95%CI (1.353, 2.138) , P<0.001〕was the risk factor of frailty in older patients in the ED, and the risk of frailty increased by 70.1% for every one score increase in NRS2002 score. Hosmer-Lemeshow test showed PA (χ2=6.120, P=0.634) , 25 (OH) D (χ2=5.386, P=0.716) and NRS2002 score (χ2=4.758, P=0.446) had good goodness of fit. ROC analysis demonstrated showed that the optimal cutoff values of PA, 25 (OH) D and NRS2002 score for predicting frailty in older patients in the ED were 211.9 mg/L, 7.06 μg/L and 3 points, respectively, and the AUCs of them were 0.749, 0.670 and 0.835, respectively. Nonparametric DeLong test showed that the AUC of NRS2002 score was greater than that of PA (Z=2.241, P=0.025) and 25 (OH) D (Z=3.400, P<0.001) .

    Conclusion

    As frail patients have poor nutritional status, nutritional assessment contributes to early identification of frailty. Among the nutrition-related parameters, PA, 25 (OH) D and NRS2002 score can effectively predict frailty in older patients in the ED, and NRS2002 score may have the strongest predictive ability.

    Intervention of Baduanjin Combined with Cognitive Training on Cognitive Frailty in Elderly Diabetic Patients: a Clinical Study
    YANG Liu, WANG Xiaoyun, YAN Huinan
    2023, 26(23):  2848-2853.  DOI: 10.12114/j.issn.1007-9572.2023.0148
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    Background

    At present, there are few intervention studies on cognitive frailty in elderly diabetic patients. This study aims to explore the application effect of Baduanjin combined with cognitive training in elderly diabetic patients with cognitive frailty, in order to provide reference for the management of this population.

    Objective

    To explore the intervention effect of Baduanjin combined with cognitive training on elderly diabetic patients with cognitive frailty.

    Methods

    A total of 84 elderly diabetic patients with cognitive frailty hospitalized in the Department of Endocrinology, Shanxi Provincial People's Hospital from October 2021 to April 2022 were selected as research subjects by convenient sampling method, and randomly divided into the experimental group (n=42) and the control group (n=42) according to the random number table method. The patients in the experimental group received Baduanjin exercise combined with cognitive training, 3 times per week for 12 weeks; patients in the control group were given routine exercise and health education. General data of the patients were collected, including gender, age, education level, marital status, residential status, personal monthly income, type of medical insurance and number of comorbid chronic diseases. The Montreal Cognitive Assessment (MoCA) score, Frailty Phenotype (FP) score, gait speed, grip strength and glycated hemoglobin A1c (HbA1c) were compared at baseline, 6 weeks and 12 weeks of intervention between the two groups.

    Results

    During the study period, 3 cases were lost to follow-up in the control group and 2 cases were lost in the experimental group, a total of 79 patients were finally included (39 cases in the control group and 40 cases in the experimental group) . There was no significant difference in the general data between the two groups (P>0.05) . There were interaction effects of group and time on MoCA score, FP score, gait speed and grip strength (P<0.05) . MoCA score of patients in the experimental group was higher than that in the control group at 12 weeks of intervention (P<0.05) , and higher than that at baseline and 6 weeks of intervention (P<0.05) . FP score of patients in the experimental group was lower than that in the control group at 12 weeks of intervention, and lower than that at baseline and 6 weeks of intervention (P<0.05) . Gait speed and grip strength of patients in the experimental group were higher than those in the control group at 12 weeks of intervention, and higher than those at baseline and 6 weeks of intervention (P<0.05) . HbA1c level of patients in the experimental group was lower than that in the control group, and lower than that at baseline at 12 weeks of intervention (P<0.05) .

    Conclusion

    Baduanjin combined with cognitive training can slow down the decline of cognitive function in elderly diabetic patients, improve physical frailty and reduce the blood glucose level of patients, which is suitable for vigorously promoting in the clinical and community settings.

    Effects of Protein Supplementation on Muscle Mass, Strength, and Physical Function in Frail/Pre-frail Older Adults: a Meta-analysis
    GUO Yinning, MIAO Xueyi, JIANG Xiaoman, XU Ting, XU Qin
    2023, 26(23):  2854-2863.  DOI: 10.12114/j.issn.1007-9572.2022.0699
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    Background

    Frailty can increase the risk of negative health-related outcomes in older adults. Protein supplementation may be an effective way to improve frailty, but there is disagreement about its effects on frailty.

    Objective

    To systematically evaluate the effects of protein supplementation on muscle mass, strength, and physical function in frail/pre-frail older adults.

    Methods

    Electronic databases of CNKI, Wanfang Data, CQVIP, PubMed, Embase, Web of Science, Cochrane Library, CINAHL and Medline were retrieved for randomized controlled trials (RCTs) of the effects of protein supplementation on muscle mass, strength and physical function in frail/pre-frail older adults published from inception to June 2022. After literature screening, the quality of eligible RCTs was evaluated, and from which relevant data were extracted. RevMan 5.4 was performed to explore the effects of protein supplementation on muscle mass, muscle strength and physical function in frail/pre-frail older adults. And for the outcome indicator of muscle strength (grip strength) , due to large amount of reported literature, this study will be based on the amount of protein supplementation (<30 g/d subgroup and≥30 g/d subgroup) , frailty status (pre-frailty subgroup, frailty subgroup, frailty and pre-frailty subgroup) , frailty assessment tool 〔frailty phenotype assessment tool (FP) subgroup and non-FP subgroup〕, population (Asian subgroup and European subgroup) , and mean age (70-<75 years subgroup, 75-<80 years subgroup, and 80-<85 years subgroup) for subgroup analysis to further explore the effect of protein supplementation on grip strength in different subgroups.

    Results

    A total of 12 RCTs were included (2 literatures for pre-frailty, 3 literatures for frailty, 7 literatures for frailty and pre-frailty) , with a total of 833 older adults (422 in the protein supplementation group and 411 in the control group) . Meta-analysis results showed that protein supplementation improved gait speed in frail/pre-frail older adults〔MD=0.03, 95%CI (0, 0.06) , P=0.05〕, but in improving muscle mass (appendicular lean mass) , muscle strength (grip strength) , other physical functions (assessment results of balance test, the timed up and go test, Short Physical Performance Battery) and frailty scores, the differences were not statistically significant (P>0.05) . The results of subgroup analysis showed that the effect of protein supplementation on the grip strength of the Asian population subgroup was significantly different from that of the European population subgroup in between-group comparisons (χ2=5.76, P=0.02) .

    Conclusion

    Protein supplementation may improve gait speed in frail/pre-frail older adults, but it does not show a significant advantage in improving their muscle mass, muscle strength and other physical functions. It is recommended to further investigate the effects of longer durations of supplementation, different types of protein supplemented, different amounts of supplementation and different regional populations on older adults with different frailty states, in order to find the best pattern of protein supplementation and provide a more sufficient evidence-based basis for frailty management.

    A Scoping Review of Frailty Assessment Tools for Elderly Orthopedic Inpatients
    QIN Lanfang, GUO Wenxi, WANG Rui, LIU Chongbin
    2023, 26(23):  2864-2870.  DOI: 10.12114/j.issn.1007-9572.2022.0866
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    Background

    With the aggravation of population aging in China, the number of elderly perioperative orthopedic patients is increasing, and the growing prevalence of frailty in older patients undergoing orthopedic surgery has attracted increasing attention. Early preoperative assessment and intervention of frailty are of great significance for improving postoperative prognosis and reducing the occurrence of complications in this population.

    Objective

    To perform a scoping review of frailty assessment tools for elderly orthopedic inpatients, and to provide a reference for the selection of frailty assessment tools for this group.

    Methods

    Seven databases (PubMed, CINAHL, PsycINFO, Scopus, Embase, CNKI and Wanfang Data) were searched for studies on frailty assessment tools for older orthopedic inpatients from 2006 to 2021. Two researchers independently screened the literature and extracted the basic characteristics of the literature (the flint author, publication time, country, basic information, research tools and outcome indicators) and the basic characteristics of involved frailty assessment tools (name, study country, study type, scale dimension, number of items, assessment cut-off value, assessment time, etc.) .

    Results

    A total of 1733 studies were retrieved, and 25 of them with 12 frailty assessment tools were included. The analysis showed that there are a variety of assessment tools, and different studies have used different frailty assessment tools. Frailty Phenotype and Frailty Index are the two common tools. The application of accurate and effective tools for frailty screening is crucial to improving preoperative risk stratification and postoperative prognosis. Frailty assessment using the Reported Edmonton Frail Scale, FRAIL Scale, PRISMA-7 Questionnaire or the Groningen Frailty Index can be completed without the use of additional measuring equipment and surveyors with an experience of training.

    Conclusion

    The selection of an optimal frailty assessment tool for elderly orthopedic inpatients should be in accordance with patient features, clinical resources and the performance of the tool. However, there is still lack of a gold standard for frailty assessment. Future studies are needed to assess the reliability and validity of existing frailty assessment scales or to develop frailty assessment tools applicable to Chinese older orthopedic inpatients.

    Advances in Multiomic Analyses of Frailty Biomarkers in the Elderly
    XU Ting, JI Minghui, CHEN Yimeng, GAO Yu, ZHU Hanfei, DING Lingyu, XU Qin
    2023, 26(23):  2871-2876.  DOI: 10.12114/j.issn.1007-9572.2022.0743
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    Early diagnosis of frailty is of great value in helping the elderly to regain their health, as it is a non-specific state of reduced physiological reserve, resistance to disease and ability to recover from stress caused by the impairment in homeostasis maintained by multiple systems with sarcopenia as the basic characteristic. Recent developments in multiomic techniques provide new approaches to the detection of potentially specific, stable and reliable biomarkers of pre-frailty. We collected and reviewed recent advances in multiomic techniques for identifying frailty biomarkers, involving genomics, transcriptomics, proteomics and metabolomics, which can assist in assessing the risk of frailty, exploring potential mechanisms of frailty and developing targeted interventions to support healthy aging.

    Original Research·Aged Care Research
    Construction of "Internet+" Family Nursing Management Model for the Elderly Based on Contracted Family Doctor Services
    GUO Yahong, GUO Haoqian, NING Yanhua, JIANG Ting, LI Meiman, LYU Xiongxiong, KONG Weijuan, LIU Haiyan
    2023, 26(23):  2876-2881.  DOI: 10.12114/j.issn.1007-9572.2023.0063
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    Background

    In recent years, with the development of mobile medicine and telemedicine technology, health management models such as Internet hospitals, online and offline cooperation have gradually become a development trend. However, the elderly have limitations in the use of "Internet+" technology, which affects the mobile health of the elderly, and develops a remote management model based on family members, helping improve the coverage and efficiency of health management for the elderly.

    Objective

    To construct an "Internet+" family nursing management model for the elderly, focusing on the contracting problem of the elderly in the context of contracted family doctor services.

    Methods

    From June 2020 to February 2021, the "Internet+" family nursing management model for the elderly was preliminarily formulated according to the policies related to the health management of the elderly, combined with domestic and foreign literature research and preliminary basic research. Applying the Delphi method, 15 experts were selected for two rounds of expert consultation, forming the final draft of the "Internet+" family nursing management model for the elderly.

    Results

    The positive coefficients of the two rounds of expert consultation were 100%, with the authority coefficients of 0.87 for both, and Kendall coordination coefficients of 0.253 and 0.226, respectively (P<0.001) . The final "Internet+" family nursing management model for the elderly consisting of 5 parts, including the service objects, management team members, the selection and training content of family caregivers, implementation method, management content with a total of 46 items was established.

    Conclusion

    This study focuses on the practical problems of elderly health management, and the "Internet +" family nursing management model constructed for the elderly not only conforms to the development of "Internet+ medical care" technology, but also realizes the participation of the elderly in remote health management, which is scientific and reliable, and can be used as a tool for remote care management of the elderly in the community.

    Comparative Study of the Effects of Gel Mattress and Air Mattress on Sacrococcygeal Pressure and Skin Temperature in Bedridden Elderly Patients
    CHEN Kesu, XU Minyi, JIANG Qixia, LIU Yuxiu, YU Hongju, HE Fang
    2023, 26(23):  2882-2887.  DOI: 10.12114/j.issn.1007-9572.2022.0741
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    Background

    Due to aging characteristics such as dry, loose and inelastic skin, and decreased skin tolerance, the elderly are more vulnerable to injuries caused by pressure. An appropriate decompression mattress is the key to preventing pressure injury.

    Objective

    To compare the decompression effects of two types of mattresses by analyzing the pressures and temperatures of sacrococcygeal skin in bedridden elderly patients in the supine position.

    Methods

    By convenience sampling, 45 bedridden elderly patients who were admitted to Cadre Internal Medicine Ward, General Hospital of Eastern Theater Command from January 2021 to March 2022 were selected as the participants (all of them were male since most of the patients in the ward were male) . They were assigned to group A (n=23, use of gel mattress, repositioned every two hours for seven days) or group B (n=22, use of air mattress, repositioned every two hours for seven days) according to their willingness. The maximal sacrococcygeal pressure and skin temperature were measured at three fixed defined time points every day during supine position〔at the beginning (baseline) , and at one and two hours in the position〕. Maximal sacrococcygeal pressure was measured using a continuous bedside pressure mapping system, and the skin temperature in the same location was measured using a hand-held thermometer. The linear mixed-effects model was used to analyse the changes in sacrococcygeal pressure and skin temperature of the elderly bedridden patients and compare the decompression effects of the two mattresses.

    Results

    There were no pressure injuries in both groups during the intervention. The interaction effect between group and day was not statistically significant on the changes in sacrococcygeal pressure (Fgroup*day=0.07, Pgroup*day=0.999) , while the interaction effect between group and time on them was statistically significant (Fgroup*time =6.45, Pgroup*time=0.012) . Therefore, the mixed-effects model analysis was conducted again after removing the interaction between the group and day. The results indicated that the sacrococcygeal pressures in the gel mattress group were lower than those in the air mattress group after one and two hours after the supine position (P<0.05) . For the changes in skin temperature, the interaction effect between group and day was not statistically significant (Fgroup*day=0.12, Pgroup*day=0.994) , while the interaction effect between group and time was statistically significant (Fgroup*time =16.90, Pgroup*time<0.001) . Therefore, the mixed-effects model analysis for temperature was conducted again after removing the interaction between the group and day. The results demonstrated that the sacrococcygeal pressure changes in the gel mattress group were lower than those in the air mattress group after one and two hours in the supine position (P<0.05) .

    Conclusion

    Both the sacrococcygeal pressures and skin temperatures of bedridden hospitalized elderly male patients were increased after using the gel mattress or air mattress for one or two hours in supine position. The pressure and skin temperature increments were less from the gel mattress than from the air mattress, indicating that gel mattress was superior to air mattress in mitigating sacrococcygeal pressure and skin temperature.

    Research Progress on the Applicaion of Human Factors Ergonomics in Intelligent Care for the Elderly
    GAO Yitian, ZHOU Wanqiong, LIU Jing, TIAN Jing, WANG Qiuyi, ZHOU Lanshu
    2023, 26(23):  2888-2893.  DOI: 10.12114/j.issn.1007-9572.2023.0060
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    With the increasing aging situation, how to successfully carry out intelligent care for the elderlyhas become an important issue, and ergonomics brings effective guarantee and new opportunities for intelligent care for the elderly. Based on the concept of ergonomics, this paper summarizes the current research status and application progress of ergonomics in the field of intelligent care for the elderly. By considering the unique cognitive, perceptual, physical function and motivational characteristics of the elderly, ergonomics makes the design of intelligent care products closer to the needs of the elderly and creates a more comfortable and convenient intelligent care environment. In the future, based on the optimization and innovation of hardware and software facilities of intelligent care through ergonomics, researchers should pay more attention to the universality and rigor of design, and integrate the characteristics of ergonomics, in order to provide high safety, convenient, and modernizedintelligentcare for the elderly.

    Original Research·Mental Health Research
    Analysis on the Correlation of Passive Suicidal Ideation with Thyroid Stimulating Hormone and Prolactin among Elderly Schizophrenia Inpatients
    CAO Ziyao, QIAN Cheng, XIE Guohua, CHANG Qingsong, WU Donghui
    2023, 26(23):  2894-2898.  DOI: 10.12114/j.issn.1007-9572.2023.0120
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    Background

    Passive suicidal ideation is a predictor of subsequent suicidal behavior, and the predictive value of objective biomarkers for suicidal ideation is attracting increasing attention. The incidence of passive suicidal ideation is relative high in elderly patients with schizophrenia. However, studies on passive suicidal ideation and biomarkers in this population are lacking.

    Objective

    To investigate the correlation of passive suicidal ideation with thyroid stimulating hormone (TSH) and prolactin (PRL) among elderly schizophrenia inpatients.

    Methods

    A total of 248 schizophrenia inpatients aged 60 years and above from Shenzhen Kangning Hospital were retrospective included from January 2014 to October 2018 and divided into the passive suicidal ideation group (n=37) and non-passive suicidal ideation group (n=211) according to the first item of the Suicide Subscale of the Chinese Version of Mini-International Neuropsychiatric Interview. The sociodemographic characteristics, TSH, free triiodothyronine (FT3) , free total-thyroxine (FT4) and PRL levels in the two groups were collected separately.

    Results

    Univariate analysis showed that the proportions of female patients, history of attempted suicide and PRL level inpassive suicidal ideation group were higher than non-passive suicidal ideation group, while the TSH level was lower than non-passive suicidal ideation group (P<0.05) . Multivariate Logistic regression analysis showed that TSH level (OR=0.654) , female (OR=10.950) , history of attempted suicide (OR=15.917) , PRL level (OR=1.018) were influencing factors of passive suicidal ideation in elderly schizophrenia inpatients (P<0.05) , PRL level (OR=1.035) was an influencing factor of passive suicidal ideation in schizophrenia inpatients aged 70 years and above (P<0.05) .

    Conclusion

    Elderly schizophrenia patients who are female, have a history of attempted suicide, have lower TSH level and higher PRL level were associated with a greater risk of passive suicide ideation. Elderly schizophrenia patients aged 70 years and above with higher PRL level may be more likely to have passive suicidal ideation, suggesting that more attention should be paid to these characteristics in clinical assessments of suicide risk.

    Effect of Childhood Trauma on Aggressive Behavior in Stable Schizophrenia Patients: the Chain Mediating Effect of Self-esteem and Resilience
    SUN Yujing, ZHANG Jing, YU Hong, ZHOU Yuqiu, JIANG Wenlong, JIA Yannan
    2023, 26(23):  2899-2906.  DOI: 10.12114/j.issn.1007-9572.2023.0030
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    Background

    Among people with various mental illnesses, those with schizophrenia have the highest incidence of aggressive behavior, which not only disturbs the medical environment, but also poses a great threat to family stability and social harmony. Previous regression analysis studies have shown that childhood trauma, self-esteem and resilience are influencing factors of aggressive behavior in schizophrenia patients, but few studies have explored the internal relationship between these four variables.

    Objective

    To explore the relationship between childhood trauma, self-esteem, resilience and aggressive behavior in schizophrenic patients using a self-constructed chain mediation model, and to clarify its internal mechanism.

    Methods

    A convenience sample of stable schizophrenia inpatients were selected from Daqing Third Hospital and Chifeng Anding Hospital from March 2021 to July 2022. A survey was conducted with them using a questionnaire consisting of general information questionnaire, Positive and Negative Symptom Scale (PANSS) , Childhood Trauma Questionnaire-Short Form (CTQ-SF) , Connor-Davidson Resilience Scale (CD-RISC) , Self-esteem Scale (SES) , and Aggressive Questionnaire (AQ) . Pearson correlation analysis was used to explore the correlation of AQ score with CTQ-SF, CD-RISC and SES scores. Multiple linear regression analysis was used to explore the influencing factors of aggressive behavior. AMOS 24.0 was used to construct the chain mediation model. The mediation effect of the chain mediation model was tested using Bootstrap method.

    Results

    Three hundred and ten cases attended the survey, and 300 of them (96.8%) who responded effectively were finally included for analysis. The average scores of PANSS, CTQ-SF, SES, CD-RISC and AQ were (18.4±3.7) , (49.7±13.5) , (26.9±6.9) , (55.2±15.5) and (84.3±19.8) , respectively. Multiple linear regression analysis showed that childhood trauma〔B=0.551, 95%CI (0.421, 0.681) , P<0.001〕, self-esteem〔B=-0.661, 95%CI (-0.908, -0.413) , P<0.001〕and resilience〔B=-0.448, 95%CI (-0.561, -0.335) , P<0.001〕 were influencing factors of aggressive behavior. Pearson correlation analysis revealed that CTQ-SF scores were positively correlated with AQ scores (r=0.695, P<0.01) and negatively correlated with SES scores and CTQ-SF scores (r=-0.524, P<0.01; r=-0.565, P<0.01) ; SES scores were negatively correlated with AQ scores (r=-0.607, P<0.01) and positively correlated with CD-RISC scores (r= 0.522, P<0.01) ; the CD-RISC score was negatively correlated with the AQ scores (r=-0.681, P<0.01) . The chain mediation model test results showed that the goodness-of-fit of the model was good. Bootstrap test showed that the 95%CI of each mediation path did not include 0, and the mediation effect was significant. The overall effect of childhood trauma on aggressive behavior was significant〔β=0.810, 95%CI (0.743, 0.871) , P<0.001〕. The indirect effect of childhood trauma on aggressive behavior, that is, acting through the mediators of self-esteem and resilience, was significant〔β=0.473, 95%CI (0.362, 0.598) , P<0.001〕. The direct effect of childhood trauma on aggressive behavior was significant〔β=0.377, 95%CI (0.179, 0.485) , P<0.001〕.

    Conclusion

    Self-esteem and resilience play a chain mediating role between childhood trauma and aggressive behavior in patients with schizophrenia. In the future, a risk prediction model of aggressive behavior in schizophrenia patients can be constructed to assess the risk of aggressive behavior, which is contributive to early identification and management of those at risk of aggression, thereby reducing or preventing the occurrence of aggressive behavior.

    Application of Cognitive Interviewing in the Development of a Help-seeking Motivation Scale for Patients with Schizophrenia
    MA Rui, WANG Yu, LI Yuxin, WANG Zhengjun, ZHOU Yuqiu
    2023, 26(23):  2907-2911.  DOI: 10.12114/j.issn.1007-9572.2022.0739
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    Background

    The accuracy of data collection can be affected by bias in the understanding of the items between the developer and the target population during scale development.

    Objective

    To adjust the items of the Schizophrenia Help-seeking Motivation Scale using the cognitive interview.

    Methods

    A purposive sampling method was used to select 30 schizophrenia patients from a psychiatric hospital in Daqing City from December 2021 to January 2022 to attend three rounds of cognitive interviews. The interview data were collected, and coded using the Question Appraisal System (QAS-99) , and after the coding results were collated, the scale entries were adjusted by integrating respondent feedback and expert panel comments.

    Results

    During the 1st round of interview, interviewees raised doubts on 11 entries, among which three were due to wording, seven were due to vague expressions, two were due to lack of inadequate knowledge, and one was due to the difficulty in recalling. And some of the entries were revised after discussion. The results of the 2nd round of interview showed that one entry was assumed to be inappropriate and was revised after discussion. The 3rd round of interview continued until the interviewees were able to understand the entries correctly, and they thought that there was no need to further revise the entries.

    Conclusion

    The cognitive interview effectively solved the problem of understanding differences between the developer and schizophrenia patients in the development of the Schizophrenia Help-seeking Motivation Scale, thus improving the accuracy and applicability of the scale.

    Drug Safety
    Comparative Study of the Efficacy and Safety of Sacubitril/Valsartan and Dapagliflozin in the Treatment of Dilated Cardiomyopathy with Low Blood Pressure
    ZHANG Yong, CAI Xiang, NING Feifei, LIANG Xiao, GUO Ning
    2023, 26(23):  2912-2917.  DOI: 10.12114/j.issn.1007-9572.2023.0050
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    Background

    Dilated cardiomyopathy has an extremely poor prognosis, sacubitril/valsartan and dapagliflozin are important drugs to improve the prognosis. However, patients with dilated cardiomyopathy tend to have low blood pressure, which would make it unable to use both drugs at the same time. There is no comparative study of the efficacy and safety of sacubitril/valsartan and dapagliflozin in the treatment of dilated cardiomyopathy with low blood pressure.

    Objective

    To investigate the efficacy and safety of sacubitril/valsartan and dapagliflozin in dilated cardiomyopathy patients with low blood pressure.

    Methods

    A total of 124 patients with dilated cardiomyopathy admitted to the First Affiliated Hospital of Xi'an Jiaotong University from March 2021 to May 2022 were selected as the study subjects. All patients were diagnosed with dilated cardiomyopathy for the first time, and the systolic blood pressure (SBP) was 95-110 mmHg before medication. Patients were prescribed with sacubitril/valsartan (50 mg/time, twice a day) or dapagliflozin tablets (10 mg/time, once a day) before or at discharge and divided into the sacubitril/valsartan group (71 cases) and dapagliflozin group (53 cases) according to clinical drug use. The outpatient follow-up was performed 6 months after discharge until November 2022. General information of the two groups such as age and gender were collected through the hospital electronic medical record system, baseline and 6-month follow-up SBP, diastolic blood pressure (DBP) , and BMI of the two groups were recorded. Baseline and 6-month biochemical indicators〔N-terminal pro-B-type natriuretic peptide (NT-proBNP) , glycated hemoglobin (HbA1c) , fasting blood glucose (FBG) , estimated glomerular filtration rate (eGFR) , blood potassium〕, cardiac function indicators〔left ventricular ejection fraction (LVEF) , left ventricular end-diastolic diameter (LVEDD) , left ventricular end-systolic diameter (LVESD) , left atrial diameter (LAD) 〕, 6 min walking test (6MWT) and clinical events were collected. The biochemical indicators, cardiac function indicators and incidence of clinical events before and after treatment were compared between the two groups.

    Results

    Compared with the pre-treatment period, the levels of blood potassium, LVEF and 6MWT were increased in the sacubitril/valsartan group and dapagliflozin group after 6 months of treatment (P<0.05) , and the elevations of 6MWT level in the dapagliflozin group was higher than that in the sacubitril/valsartan group (t=2.444, P=0.016) . Compared with the pre-treatment period, the levels of SBP, DBP, BMI, NT-proBNP, HbA1c, FBG, LVEDD, LVESD, LAD were decreased in the sacubitril/valsartan group and dapagliflozin group after 6 months of treatment (P<0.05) , the reductions of SBP (Z=5.217, P<0.001) , DBP (t=3.070, P=0.003) , eGFR (Z=2.495, P=0.013) levels in the sacubitril/valsartan group and BMI (Z=4.410, P<0.001) , HbA1c (Z=4.493, P<0.001) , FBG (t=4.832, P<0.001) , LAD (Z=2.830, P=0.005) levels in the dapagliflozin group were higher. There were no deaths or hypoglycemic discontinuation events in the two groups during 6 months of follow-up, and there were no statistical differences in the incidence of hypotension discontinuation, hyperkalemia discontinuation, renal insufficiency discontinuation, urinary system infection discontinuation and heart failure re-hospitalization between the two groups (P>0.05) .

    Conclusion

    Both sacubitril/valsartan and dapagliflozin were effective in improving cardiac function in dilated cardiomyopathy patients with low blood pressure. The safety of the two groups is similar. However, the use of sacubitril/valsartan should be noted for the risk of hypotension and renal insufficiency.

    Effect of Sodium Valproate, Oxcarbazepine and Levetiracetam on the Development of Different Functional Areas in Children with Epilepsy by Griffiths Development Scales-Chinese Edition
    BAI Yanmin, DU Kaixian, CHEN Hao, JIA Tianming, GONG Huan, YU Shengyuan, LI Lin, GUAN Jing, ZHU Yingying
    2023, 26(23):  2918-2922.  DOI: 10.12114/j.issn.1007-9572.2023.0102
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    Background

    Epilepsy is a chronic episodic brain disorder with a high incidence and can seriously affect the quality of life of the patients. Therefore, timely treatment to control seizures is particularly important. Numerous studies have shown the effect of antiepileptic drugs on cognition, but there are few studies on the effects of different functional areas in children.

    Objective

    To explore the effects of sodium valproate (VPA) , oxcarbazepine (OXC) and levetiracetam (LEV) on the development of different functional areas in children with focal epilepsy by Griffiths Development Scales-Chinese Edition (GDS-C) .

    Methods

    A total of 83 children with focal epilepsy who attended in outpatient and ward of the Department of Pediatric Neurology of the Third Affiliated Hospital of Zhengzhou University for the first time from January 2021 to April 2022 were selected, and randomly divided into VPA group (n=27) , OXC group (n=28) and LEV group (n=28) according to the random number table method, 30 healthy children who were examined during the same period were selected as the control group. The changes of EEG interictal epileptiform activity (IEA) before and after 6 months of treatment were recorded and the clinical effect was evaluated according to seizure frequency, the GDS-C was used to evaluate the development quotient of each functional area in the children.

    Results

    The total clinical effective rates of VPA group, OXC group and LEV group were 92.6%, 89.3% and 92.9%, with no significant difference among the three groups (χ2=0.418, P=1.000) . The total EEG IEA effective rate of the VPA group, OXC group and LEV group were 88.9%, 57.1% and 89.3%, with significant differences among the three groups (χ2=11.152, P=0.004) ; the total effective rate of EEG IEA in OXC group was lower than that in VPA group and LEV group (P<0.05) . Before treatment, there were statistically significant differences in the the development quotient of each dimension among four groups (P<0.05) ; the development quotient of each dimension in three groups were lower than that in the control group (P<0.05) . After treatment, there were significant differences in the the development quotients of hand-eye coordination and performance dimensions among three groups (P<0.05) ; the development quotients of sports and personal-social dimensions in LEV group were higher than VPA group (P<0.05) , the development quotients of personal-social, hand-eye coordination and performance dimensions in LEV group were higher than OXC group (P<0.05) . Compared to the pre-treatment period, the development quotients of personal-social and practical reasoning dimensions significantly decreased in VPA group (P<0.05) , the development quotients of personal-social, language, hand-eye coordination, performance and practical reasoning dimensions significantly increased (P<0.05) .

    Conclusion

    VPA, OXC and LEV are all effective in the treatment of focal epilepsy in children, and all three have quivalent efficacy; In terms of improving EEG IEA, OXC is inferior to VPA and LEV; VPA may have a negative effect on personal-social and practical reasoning dimensions, OXC has little effect, and LEV may have improvement on personal-social, language, hand-eye coordination, performance, practical reasoning dimensions.

    Retrospective Analysis of 2 992 Times of Therapeutic Drug Monitoring of Valproic Acid from 2019 to 2021
    DING Jing, MENG Zhuocheng, ZHANG Yan, CUI Xiaohua, LIU Jiarui, HE Jiao, ZHANG Yang, LI Yajuan, YANG Liu
    2023, 26(23):  2923-2929.  DOI: 10.12114/j.issn.1007-9572.2023.0016
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    Background

    Valproic acid, as a mood stabilizer, has been extensively used for the treatment of bipolar disorder and other psychiatric conditions. Although therapeutic drug monitoring (TDM) of valproic acid has been carried out at home and abroad for many years, controversies persist regarding the influence of age, sex and other factors on its plasma concentration.

    Objective

    To analyze the TDM results of valproic acid, providing a reference for rationalized individualized treatment of bipolar disorders or other psychiatric conditions.

    Methods

    Through the laboratory information system of Ruimei Medical Laboratory, information on TDM of valproic acid in outpatients and inpatients (including the patient's age, sex, TDM raw data, monitoring samples, and monitoring frequency) was obtained from Xi'an Mental Health Center from 2019 to 2021. The plasma concentration of valproic acid was classified into three categories (<50 mg/L, 50-100 mg/L and >100 mg/L) according to the therapeutic window range recommended in the Consensus Guidelines for Therapeutic Drug Monitoring in Neuropsychopharmacology (hereinafter referred to as AGNP Consensus) , and the percent of each category was calculated. And subsequent data analysis was performed using MedCalc 5.2.

    Results

    A total of 2 431 patients were monitored 2 992 times for understanding valproic acid treatment status, of which 1 637 were for men, and 1 355 for women. The frequencies of TDM of valproic acid increased by 54.93% in 2020 and 44.00% in 2021 compared to those reported in 2019. The proportion of patients who received only once was about 74.41%. Compared with inpatients, outpatients had higher prevalence of receiving one TDM of valproic acid (χ2=95.15, P<0.001) , and lower prevalence of receiving two, or at least three TDM of valproic acid (χ2=49.41, 34.24, P<0.001) . The plasma valproic acid concentration in inpatients was higher than that in outpatients (Z=-11.60, P<0.001) . Meanwhile, higher plasma valproic acid concentration was observed in female patients than in male patients (Z=-4.39, P<0.001) . However, there was no significant difference between the age groups (Z=0.75, P>0.05) . For each study year 2019-2021, the proportion of plasma concentration of valproic acid within the therapeutic window was 57.72%, which was significantly higher than that of the proportion of below and above the therapeutic window (χ2=155.38, 1 216.68, P<0.001) . The proportion of the plasma valproic acid concentration (<50 mg/L, 50-100 mg/L, or >100 mg/L) had statistically significant differences between different age and gender groups, and over the years (P<0.05) . The plasma valproic acid concentration ranged between 40-80 mg/L for males, females, or total participants, which was slightly lower than the therapeutic range (50-100 mg/L) recommended by the AGNP Consensus.

    Conclusion

    The individual treatment program in patients should be determined clinically according to age and sex to increase the proportion of plasma valproic acid concentration in the therapeutic window. Additionally, TDM of valproic acid should be emphasized in inpatients and outpatients to ensure safe and effective medication administration in clinical practice.

    Ideas for the Diagnosis and Treatment of Multisystem Immune-related Adverse Events Caused by Immune Checkpoint Inhibitors
    ZHANG Yanjing, SONG Xiaokun
    2023, 26(23):  2930-2935.  DOI: 10.12114/j.issn.1007-9572.2022.0585
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    As a new type of anti-cancer therapy, immune checkpoint inhibitors (ICIs) have transformed the treatment of various cancers. However, ICIs are associated with many potential complications, namely immune-related adverse events (irAEs) , possibly involving the nervous, cardiac, pulmonary, cutaneous, renal, gastrointestinal, hepatic, and hematologic systems. Although a series of guidelines for the management of irAEs have been issued, early identification, diagnosis and treatment of irAEs in clinical practice are still not standardized enough due to different levels of awareness and attention regarding the disease across clinicians. We analyzed the clinical data of a patient with severe multisystem irAEs developed after treatment with cindilimab, and reviewed relevant literature, then summarized the benefits and limitations of treatments for irAEs, providing ideas for better managing multisystem irAEs clinically.

    Review & Perspectives
    Advances in Health Anxiety and Its Online Cognitive-behavioral Interventions
    ZHANG Xinyi, XU Muzi, ZHENG Yan, ZHAO Yue
    2023, 26(23):  2936-2942.  DOI: 10.12114/j.issn.1007-9572.2022.0482-1
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    The development of information dissemination is associated with significantly increased risk of health anxiety (HA) , imposing a heavy burden on individuals and society. Although there are inconsistencies between the evolution and revisions in clinical diagnosis of HA, cognitive-behavioral interventions have been recognized as effective treatments for HA. We reviewed the clinical diagnoses, measurement tools, associated factors and online cognitive-behavioral interventions of HA, then proposed that the concepts and measurement tools of HA need to be further standardized. Main difficulties are the determination of the threshold for intervention and the development of psychological interventions suitable for general practices. Online and face-to-face cognitive-behavioral interventions for HA have similar effects, but the former is more inexpensive and convenient, which deserve to be studied further.

    Effects of Interactive Reading Interventions on Oral Communication in Preschool Children with Autism Spectrum Disorders: a Research Progress
    LIANG Shuqin, LI Jing
    2023, 26(23):  2943-2950.  DOI: 10.12114/j.issn.1007-9572.2022.0764
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    Foreign studies suggest that interactive reading is an exploratory intervention for improving the oral language skill of children with autism in their early years. We summarized and analyzed empirical studies on the effects of interactive reading interventions on oral communication skills of preschool children with autism. The results indicate that the interventions have positive impacts on vocabulary development and spontaneous responses in preschool children with autism, but have discrepant effects on their spontaneous initiations. However, due to the small sample size of these studies, the effects of interactive reading interventions on oral communication in preschoolers with autism need to be further studied. It is expected that future research will explore and verify the effects of interactive reading interventions on both spontaneous responses and initiations in large samples of autism preschoolers, and further investigate whether these effects can be maintained and generalized.