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    Novel Developments in Lung and Gut Microbiota and Their Cross-talk with the Development of Chronic Obstructive Pulmonary Disease
    SHEN Junxi, ZHU Xing, CHEN Yunzhi, LI Wen
    Chinese General Practice    2023, 26 (20): 2548-2554.   DOI: 10.12114/j.issn.1007-9572.2022.0539
    Abstract572)   HTML19)    PDF(pc) (1833KB)(457)       Save

    Chronic obstructive pulmonary disease (COPD) is a common chronic respiratory disease that greatly threatens human health. Studies have found that compared with the healthy population, the mucosal barrier function and immune homeostasis in COPD patients are impaired due to significantly changed composition and structure of both lung and gut microbiota, which further aggravate the disease progression. Taking measures to actively improve the microbial balance in lung and gut microbiota is very important for the prevention and delaying of the development of COPD. However, the summary and understanding of the role of lung and gut microbiota and their cross-talk mechanism in COPD still have much room for development. We reviewed the latest developments in the composition characteristics of lung and gut microbiota and the possible cross-talk mechanism between them in healthy people and COPD patients, as well as the prevention and treatment of COPD based on lung and gut microbiota and their cross-talk, providing new ideas for pathogenesis exploration, early diagnosis, prevention and treatment of COPD.

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    A Review of Recent Advances in Screening for Obstructive Sleep Apnea during Pregnancy
    WANG Jingyu, HONG Shenda, HAN Fang, LIU Guoli
    Chinese General Practice    2023, 26 (20): 2555-2558.   DOI: 10.12114/j.issn.1007-9572.2022.0754
    Abstract324)   HTML11)    PDF(pc) (1663KB)(222)       Save

    Obstructive sleep apnea (OSA) is a common sleep-disordered breathing in pregnant population, which is associated with adverse perinatal outcomes, and may have long-term health consequences on both mothers and children. Currently, the vast majority of pregnant women are underdiagnosed due to the difficulties in extensively performing polysomnography, a gold standard in OSA diagnosis. So it is essential to seek other screening strategies and tools to accurately identify pregnant women with high risk of OSA to improve their perinatal outcomes. We reviewed the prevalence of OSA in pregnancy, screening status, screening timing, target population and recent advances in screening tools, to providing a theoretical basis for implementing the screening in this group.

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    New Research Progress of a New Auxiliary Antihypertensive Model Targeting Intestinal Flora
    Xiaojun HUANG, Jin YANG, Yaqimei LEI, Zhijie ZENG, Zhaohui JIN
    Chinese General Practice    2022, 25 (18): 2297-2302.   DOI: 10.12114/j.issn.1007-9572.2022.02.023
    Abstract801)   HTML19)    PDF(pc) (2365KB)(346)       Save

    As an important part of the internal environment of human, intestinal flora participates in and regulates the immune inflammatory response and metabolic process of the body. It is closely related to the occurrence and development of hypertension, and has become the focus of research on hypertension. The thesis summarizes the relationship between intestinal flora and hypertension, then clarifies their effects and possible mechanisms on hypertension in terms of inflammation and immune response, brain-intestine-bone marrow axis and metabolites, focusing on the new auxiliary antihypertensive pathways that dietary intervention affects intestinal flora to improve blood pressure from salt, probiotics and polyphenols. It is hoped that more in-depth research will come out on improving hypertension through dietary intervention and Chinese herbal medicine prevention and treatment with intestinal flora as the target.

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    Application Research Progress of Continuous Blood Glucose Monitoring System in Patients with Gestational Diabetes Mellitus
    Yuan GAO, Min ZHOU
    Chinese General Practice    2022, 25 (18): 2302-2306.   DOI: 10.12114/j.issn.1007-9572.2022.0040
    Abstract821)   HTML26)    PDF(pc) (2127KB)(450)       Save

    The "Decision of the Central Committee of the Communist Party of China and the State Council on Optimizing the Fertility Policy to Promote the Long-term Balanced Development of the Population" issued in June 2021made a major decision to implement the three-child policy, and the number of pregnant women will increase significantly. As one of the common complications during pregnancy, gestational diabetes seriously affects the health of pregnant women and fetuses. Continuous blood glucose monitoring has been called "the road map for effective self-management" and is critical in the management of blood glucose in people with gestational diabetes. This article reviews the development of continuous blood glucose monitoring and its application and impact in patients with gestational diabetes, in order to promote the clinical application of continuous blood glucose monitoring, encourage patients with gestational diabetes to participate in diabetes response and improve accurate blood glucose management.

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