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    Novel Developments in Lung and Gut Microbiota and Their Cross-talk with the Development of Chronic Obstructive Pulmonary Disease
    SHEN Junxi, ZHU Xing, CHEN Yunzhi, LI Wen
    Chinese General Practice    2023, 26 (20): 2548-2554.   DOI: 10.12114/j.issn.1007-9572.2022.0539
    Abstract572)   HTML19)    PDF(pc) (1833KB)(458)       Save

    Chronic obstructive pulmonary disease (COPD) is a common chronic respiratory disease that greatly threatens human health. Studies have found that compared with the healthy population, the mucosal barrier function and immune homeostasis in COPD patients are impaired due to significantly changed composition and structure of both lung and gut microbiota, which further aggravate the disease progression. Taking measures to actively improve the microbial balance in lung and gut microbiota is very important for the prevention and delaying of the development of COPD. However, the summary and understanding of the role of lung and gut microbiota and their cross-talk mechanism in COPD still have much room for development. We reviewed the latest developments in the composition characteristics of lung and gut microbiota and the possible cross-talk mechanism between them in healthy people and COPD patients, as well as the prevention and treatment of COPD based on lung and gut microbiota and their cross-talk, providing new ideas for pathogenesis exploration, early diagnosis, prevention and treatment of COPD.

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    A Review of Recent Advances in Screening for Obstructive Sleep Apnea during Pregnancy
    WANG Jingyu, HONG Shenda, HAN Fang, LIU Guoli
    Chinese General Practice    2023, 26 (20): 2555-2558.   DOI: 10.12114/j.issn.1007-9572.2022.0754
    Abstract324)   HTML11)    PDF(pc) (1663KB)(222)       Save

    Obstructive sleep apnea (OSA) is a common sleep-disordered breathing in pregnant population, which is associated with adverse perinatal outcomes, and may have long-term health consequences on both mothers and children. Currently, the vast majority of pregnant women are underdiagnosed due to the difficulties in extensively performing polysomnography, a gold standard in OSA diagnosis. So it is essential to seek other screening strategies and tools to accurately identify pregnant women with high risk of OSA to improve their perinatal outcomes. We reviewed the prevalence of OSA in pregnancy, screening status, screening timing, target population and recent advances in screening tools, to providing a theoretical basis for implementing the screening in this group.

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