Content of Research of Brain Health：Cognitive Dysfunction in our journal

Published in last 1 year |  In last 2 years |  In last 3 years |  All Please wait a minute... For Selected: Download Citations EndNote Ris BibTeX Toggle Thumbnails Select Predictive Value of Sensory Dysfunction in Early Recognition and Treatment of Cognitive Dysfunction: a Review Yunyun MA, Yulei SONG, Mengmeng WANG, Xiao LIANG, Xueqing ZHANG, Guihua XU, Dandan DU, Yamei BAI Chinese General Practice    2022, 25 (23): 2899-2902.   DOI: 10.12114/j.issn.1007-9572.2022.0328 Abstract （827）   HTML （12）    PDF（pc） （2016KB）（327）       Knowledge map    Save The initial symptoms of cognitive dysfunction disease are insidious, and most of the cognitive dysfunction diseases will be in the stage of dementia with no effective treatment when the symptoms are discovered. Therefore, it is crucial to explore simple and easy-to-check warning signals of cognitive dysfunction diseases and carry out timely and effective interventions for the prevention and treatment of cognitive dysfunction diseases. A large number of studies have shown that sensory dysfunction is of great value in the early diagnosis, assessment and treatment of cognitive dysfunction. However, at present, cognitive function screening in China mostly relies on neuropsychological tests, highly sensitive sensory indicators such as smell and hearing were not included. This paper concluded that further detecting the sensory function status of the elderly on the basis of neuropsychological testing will greatly improve the accuracy of cognitive dysfunction disease screening, clarified the value of sensory dysfunctions such as smell, hearing, vision, and taste in the early diagnosis and treatment of cognitive dysfunction diseases by the review and analysis of previous literature, in order to provide new ideas for clinical work. Reference | Related Articles | Metrics Select Advances in the Mechanism of Enriched Environment Improving Chronic Cerebral Hypoperfusion-induced Cognitive Impairment Huanhuan LIU, Jing GAO, Kaiqi SU, Xiaodong FENG Chinese General Practice    2022, 25 (23): 2903-2909.   DOI: 10.12114/j.issn.1007-9572.2022.0122 Abstract （682）   HTML （7）    PDF（pc） （2402KB）（244）       Knowledge map    Save Chronic cerebral hypoperfusion-induced cognitive impairment (CCHCI) is a cognitive deficit caused by cerebral cortex or subcortical infarction, white matter degeneration, blood-cerebrospinal fluid barrier, and hippocampal injury due to long-term hypoperfusion of the brain. Clinical evidence shows that there is still no effective pharmacological treatment for CCHCI. But numerous animal studies have demonstrated that enriched environment can alleviate brain tissue damage caused by chronic hypoperfusion and promote nerve growth and functional recovery in ischemic brain areas. We reviewed the latest advances in the use of enriched environment as a non-drug intervention for CCHCI in animal models via regulating autophagy and epigenetic mechanisms to inhibit oxidative stress, protect the blood-cerebrospinal fluid barrier, promote neurovascular reconstruction and stimulate synaptic plasticity. We hope the review could provide new ideas for the treatment and clinical research of CCHCI to reverse CCHCI-induced neurological impairment and improve cognitive impairment. Reference | Related Articles | Metrics Select Pathogenesis of Cognitive Deficits Induced by Hippocampal Mitochondrial Dysfunction in Vascular Dementia: a Review of the Latest Developments Xin ZHANG, Ping LI, Yuhan WANG, Caiping ZHENG, Xiaoyan DENG, Luming QI, Juan LI, Yijing JIANG, Lina XIA Chinese General Practice    2022, 25 (23): 2910-2916.   DOI: 10.12114/j.issn.1007-9572.2022.0213 Abstract （830）   HTML （16）    PDF（pc） （2444KB）（397）       Knowledge map    Save Hippocampal mitochondrial dysfunction is closely related to cognitive deficits in vascular dementia. We reviewed the latest developments in the internal associations of hippocampal mitochondrial dysfunction with cognitive deficits in vascular dementia, which mainly encompass seven aspects: abnormal mitochondrial autophagy, abnormal apoptotic pathway, oxidative damage, abnormal biosynthetic function, dynamic imbalance, imbalance of calcium homeostasis and abnormal respiratory function. According to the evidence, hippocampal mitochondrial dysfunction may be a major cause of cognitive impairment in vascular dementia, which provides insights into the development of new ideas and effective ways for clinical prevention and improvement of cognitive function in vascular dementia. Reference | Related Articles | Metrics