Abstract: Background　Venous thromboembolism (VTE) is the third leading cause of cardiovascular mortality.Anticoagulant therapy remains the mainstay of treatment and prevention. Previous studies have shown that postdischarge adherence to anticoagulant therapy is one of the major determinants of anticoagulation effectiveness. Mobile health technologies have shown potential in the long-term management of chronic diseases. However, whether mobile health-based interventions can improve postdischarge medication adherence in patients with VTE, and the magnitude of such benefit, remain unclear.Objective　To evaluate the effectiveness of mobile health technology in improving postdischarge adherence to anticoagulant therapy among patients with VTE. Methods　This was a single-center, prospective, single-arm cohort study with a pre-post intervention design. A total of 274 patients with VTE admitted to the Sixth Medical Center of the Chinese PLA General Hospital between May and August 2025 were enrolled. All patients received mobile health-assisted postdischarge anticoagulation management for 90 days after discharge. Changes in postdischarge anticoagulant adherence before and after the intervention were assessed using the Chinese version of the 8-item Morisky Medication Adherence Scale (MMAS-8). Results　The mean age of the 274 patients was 62.54±15.28 years. Of these, 239 patients (87.2%) had deep vein thrombosis, and 35 patients (12.8%) had pulmonary embolism. Before the intervention, 69 patients (25.2%) had high adherence, 114 patients (41.6%) had moderate adherence, and 91 patients (33.2%) had low adherence. The main manifestations of poor adherence were "sometimes forgetting to take medication" and "feeling hassled about adhering to the treatment plan", with mean item scores of 0.58±0.47 and 0.58±0.50, respectively. After the intervention, the number of patients with high adherence increased to 101 (36.9%), representing a relative increase of 46.4% compared with baseline; this improvement was statistically significant (P<0.001). The mean scores for the items "sometimes forgetting to take medication" and "feeling hassled about adhering to the treatment plan" increased to 0.73±0.45 and 0.66±0.48, respectively, with statistically significant differences compared with baseline (P<0.05). Conclusion　Mobile health technology can improve outpatient anticoagulant medication adherence among patients with VTE to a certain extent, particularly in reducing missed doses and alleviating the burden of medication management. These findings suggest its potential value in supporting self-management of outpatient anticoagulation in patients with VTE.

Key words: Venous thromboembolism, Mobile health technology, Anticoagulant adherence, Personalization management, Prospective study, Intervention effect

摘要： 背景　静脉血栓栓塞症（VTE）是心血管疾病中的第三大主要死因，目前抗凝治疗是主要的治疗和预防方式。目前已有研究表明，患者院外抗凝药物依从性是影响抗凝疗效的主要因素之一，并且移动健康技术在各慢性病的长期管理方面具有一定的潜力。但移动健康技术的干预是否对患者院外药物依从性的改善有管理帮助作用，帮助的效果如何，目前尚不清楚。目的　探讨移动健康技术辅助VTE患者院外抗凝药物依从性的有效性。方法　本研究为单中心、前瞻性、单组队列研究，采用前后对照设计。选取2025年5—8月中国人民解放军总医院第六医学中心所收治的274例VTE患者作为研究对象。患者在出院后90 d均接受移动健康技术辅助院外抗凝管理。采用中文版Morisky-8药物依从性量表（MMAS-8）评估干预前后患者院外抗凝药物依从性变化。结果　274例患者平均年龄（62.54±15.28）岁，239例（87.2%）为深静脉血栓（DVT）患者，35例（12.8%）为肺栓塞（PE）患者。干预前，274例患者中，依从性良好患者69例（25.2%），中等依从性患者114例（41.6%），低依从性患者91例（33.2%）。依从性较差的主要表现为“有时会忘记服药”和“坚持按治疗计划服药感到麻烦”，其条目平均得分分别为（0.58±0.47）分和（0.58±0.50）分。干预后，高依从性患者增至101例（36.9%），增加率为46.4%，较干预前明显提高，差异有统计学意义（P<0.001）。针对“有时会忘记服药”及“坚持按治疗计划服药感到麻烦”两个条目的平均得分分别提高至（0.73±0.45）分和（0.66±0.48）分，差异有统计学意义（P<0.05）。结论　移动健康技术可在一定程度上提高VTE患者院外抗凝药物依从性，尤其对改善忘服药及服药管理负担等问题具有积极作用，提示其在VTE患者院外抗凝自我管理中具有积极应用价值。

关键词: 静脉血栓栓塞症, 移动健康技术, 抗凝药物依从性, 个性化管理, 前瞻性研究, 干预效果