Comparative Study of Non-motor Symptoms of Patients with Parkinson Disease between Early and Middle and Advanced Phases

doi:10.3969/j.issn.1007-9572.2016.34.010

Abstract

Abstract: Objective　To compare the occurrence of non-motor symptoms（NMS） of patients with Parkinson disease（PD） between early and middle and advanced stages.Methods　125 PD patients who received hospitalization in the Department of Neurology,the First Affiliated Hospital of Wenzhou Medical University from January 2013 to January 2015 were enrolled in the study.According to Hoehn-Yahr scale,all subjects were divided into the early phases（1～2 phases,n=56） and middle and advanced phases（3～5 phases,n=69）.The dyskinesia of patients were evaluated through the third part of Unified Parkinson Disease Rating Scale（UPDRS-Ⅲ） adopted by neurologists,and their NMS was evaluated by Non-Motor Symptoms Questionnaire（NMSQuest）.Results　There was no significant difference in the incidence of NMS between PD patients in early and middle and advanced phases（P>0.05）;while there was significant difference in the incidence of gastrointestinal symptoms,urinary system symptoms,disordered sexual function,cardiovascular system symptoms,dysmnesia/indifference,hallucinations/delusions,depression/anxiety,sleep disorders and other symptoms（P<0.05）.The incidence of gastrointestinal symptoms in early and middle and advanced phases was 57.1%（32/56） and 76.8%（53/69）,respectively.The results of Spearman rank correlation analysis showed that the number of NMS in PD patients was positively correlated with UPDRS-Ⅲ scores（P<0.05）.Conclusion　A wide range of NMS throughout the entire disease course of PD,and the gastrointestinal symptoms are common.NMS may aggravates with the progression of the disease,and dyskinesia is correlated with NMS.

Key words: Parkinson disease, Disease stage, Non-motor symptoms

摘要： 目的　比较早期与中晚期帕金森病（PD）患者的非运动症状（NMS）发生情况。方法　选取2013年1月—2015年1月在温州医科大学附属第一医院神经内科接受住院治疗的PD患者125例，根据Hoehn-Yahr分级分为早期（1～2级，n=56）和中晚期（3～5级，n=69）。由神经科医师采用统一帕金森病评定量表第Ⅲ部分（UPDRS-Ⅲ）评价患者的运动障碍，采用帕金森病非运动症状问卷（NMSQuest）评价患者的NMS。结果　早期与中晚期PD患者的NMS发生率比较，差异无统计学意义（P>0.05）；但消化系统症状、泌尿系统症状、性功能异常、心血管系统症状、记忆障碍/淡漠、幻觉/妄想、抑郁/焦虑、睡眠障碍及其他症状发生率比较，差异均有统计学意义（P<0.05）。其中，早期与中晚期患者的消化系统症状发生率分别为57.1%（32/56）、76.8%（53/69）。Spearman秩相关结果显示，PD患者的NMS数量与UPDRS-Ⅲ得分呈正相关（P<0.05）。结论　NMS贯穿于PD的整个病程，以消化系统症状较为常见，可能随病程进展逐渐加重，运动障碍与NMS间存在相关性。

关键词: 帕金森病, 病情分期, 非运动症状

LI Jing, CHEN Wei-an, ZHANG Xu, TONG Qiu-ling. Comparative Study of Non-motor Symptoms of Patients with Parkinson Disease between Early and Middle and Advanced Phases[J]. Chinese General Practice, 2016, 19(34): 4201-4204.

李静, 陈为安, 张旭, 童秋玲. 早期与中晚期帕金森病患者非运动症状的比较研究[J]. 中国全科医学, 2016, 19(34): 4201-4204.

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