Chinese General Practice ›› 2022, Vol. 25 ›› Issue (18): 2262-2267.DOI: 10.12114/j.issn.1007-9572.2021.02.080
Special Issue: 肿瘤最新文章合辑; 消化系统疾病最新文章合辑
• Original Research • Previous Articles Next Articles
Received:
2021-09-27
Revised:
2022-02-24
Published:
2022-06-20
Online:
2022-04-22
Contact:
Quanxiao XU
About author:
通讯作者:
徐全晓
作者简介:
基金资助:
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URL: https://www.chinagp.net/EN/10.12114/j.issn.1007-9572.2021.02.080
临床病理特征 | PD-L1 mRNA相对表达量 | CD8+ TILs密度 | |||||||
---|---|---|---|---|---|---|---|---|---|
低水平组(n=73) | 高水平组(n=52) | χ2(t)值 | P值 | 低密度组(n=55) | 高密度组(n=70) | χ2(t)值 | P值 | ||
年龄( | 56.8±6.3 | 57.4±5.2 | -0.563a | 0.574 | 56.0±4.5 | 57.8±7.5 | -1.571a | 0.119 | |
性别〔n(%)〕 | 0.946 | 0.331 | 0.332 | 0.565 | |||||
男 | 47(64.4) | 29(55.8) | 35(63.6) | 41(58.6) | |||||
女 | 26(35.6) | 23(44.2) | 20(36.4) | 29(41.4) | |||||
手术类型〔n(%)〕 | 0.809 | 0.368 | 0.315 | 0.575 | |||||
腹腔镜手术 | 62(84.9) | 47(90.4) | 49(89.1) | 60(85.7) | |||||
开腹手术 | 11(15.1) | 5(9.6) | 6(10.9) | 10(14.3) | |||||
分化程度〔n(%)〕 | 2.946 | 0.086 | 0.1915 | 0.339 | |||||
分化 | 45(61.6) | 24(46.2) | 33(60.0) | 36(51.4) | |||||
未分化 | 28(38.4) | 28(53.8) | 22(40.0) | 34(48.6) | |||||
浸润深度〔n(%)〕 | 0.743 | 0.389 | 11.927 | 0.001 | |||||
T1~T2 | 49(67.1) | 31(59.6) | 26(47.3) | 54(77.1) | |||||
T3~T4 | 24(32.9) | 21(40.4) | 29(52.7) | 16(22.9) | |||||
淋巴结转移〔n(%)〕 | 6.671 | 0.010 | 8.406 | 0.004 | |||||
无 | 20(27.4) | 26(50.0) | 28(50.9) | 18(25.7) | |||||
有 | 53(72.6) | 26(50.0) | 27(49.1) | 52(74.3) | |||||
脉管侵犯〔n(%)〕 | 6.290 | 0.012 | 6.186 | 0.013 | |||||
无 | 55(75.3) | 28(53.8) | 30(54.5) | 53(75.7) | |||||
有 | 18(24.7) | 24(46.2) | 25(45.5) | 17(24.3) | |||||
腹膜转移〔n(%)〕 | 4.283 | 0.038 | 5.263 | 0.022 | |||||
无 | 65(89.0) | 39(75.0) | 41(74.5) | 63(90.0) | |||||
有 | 8(11.0) | 13(25.0) | 14(25.5) | 7(10.0) |
Table 1 Relations of relative expression quantity of PD-L1 mRNA,density of CD8+ TILs in gastric cancer tissues with clinicopathological characteristics of patients with gastric cancer
临床病理特征 | PD-L1 mRNA相对表达量 | CD8+ TILs密度 | |||||||
---|---|---|---|---|---|---|---|---|---|
低水平组(n=73) | 高水平组(n=52) | χ2(t)值 | P值 | 低密度组(n=55) | 高密度组(n=70) | χ2(t)值 | P值 | ||
年龄( | 56.8±6.3 | 57.4±5.2 | -0.563a | 0.574 | 56.0±4.5 | 57.8±7.5 | -1.571a | 0.119 | |
性别〔n(%)〕 | 0.946 | 0.331 | 0.332 | 0.565 | |||||
男 | 47(64.4) | 29(55.8) | 35(63.6) | 41(58.6) | |||||
女 | 26(35.6) | 23(44.2) | 20(36.4) | 29(41.4) | |||||
手术类型〔n(%)〕 | 0.809 | 0.368 | 0.315 | 0.575 | |||||
腹腔镜手术 | 62(84.9) | 47(90.4) | 49(89.1) | 60(85.7) | |||||
开腹手术 | 11(15.1) | 5(9.6) | 6(10.9) | 10(14.3) | |||||
分化程度〔n(%)〕 | 2.946 | 0.086 | 0.1915 | 0.339 | |||||
分化 | 45(61.6) | 24(46.2) | 33(60.0) | 36(51.4) | |||||
未分化 | 28(38.4) | 28(53.8) | 22(40.0) | 34(48.6) | |||||
浸润深度〔n(%)〕 | 0.743 | 0.389 | 11.927 | 0.001 | |||||
T1~T2 | 49(67.1) | 31(59.6) | 26(47.3) | 54(77.1) | |||||
T3~T4 | 24(32.9) | 21(40.4) | 29(52.7) | 16(22.9) | |||||
淋巴结转移〔n(%)〕 | 6.671 | 0.010 | 8.406 | 0.004 | |||||
无 | 20(27.4) | 26(50.0) | 28(50.9) | 18(25.7) | |||||
有 | 53(72.6) | 26(50.0) | 27(49.1) | 52(74.3) | |||||
脉管侵犯〔n(%)〕 | 6.290 | 0.012 | 6.186 | 0.013 | |||||
无 | 55(75.3) | 28(53.8) | 30(54.5) | 53(75.7) | |||||
有 | 18(24.7) | 24(46.2) | 25(45.5) | 17(24.3) | |||||
腹膜转移〔n(%)〕 | 4.283 | 0.038 | 5.263 | 0.022 | |||||
无 | 65(89.0) | 39(75.0) | 41(74.5) | 63(90.0) | |||||
有 | 8(11.0) | 13(25.0) | 14(25.5) | 7(10.0) |
变量 | 赋值 |
---|---|
年龄 | 实测值 |
性别 | 女=0,男=1 |
手术类型 | 开腹手术=0,腹腔镜手术=1 |
分化程度 | 分化=0,未分化=1 |
浸润深度 | T1~T2=0,T3~T4=1 |
淋巴结转移 | 无=0,有=1 |
脉管侵犯 | 无=0,有=1 |
腹膜转移 | 无=0,有=1 |
PD-L1 mRNA相对表达量 | 低水平=0,高水平=1 |
CD8+ TILs密度 | 高密度=0,低密度=1 |
预后 | 良好=0,不良=1 |
Table 2 Variable assignment of univariate and multivariate Cox regression analysis of factors affecting prognosis of patients with gastric cancer
变量 | 赋值 |
---|---|
年龄 | 实测值 |
性别 | 女=0,男=1 |
手术类型 | 开腹手术=0,腹腔镜手术=1 |
分化程度 | 分化=0,未分化=1 |
浸润深度 | T1~T2=0,T3~T4=1 |
淋巴结转移 | 无=0,有=1 |
脉管侵犯 | 无=0,有=1 |
腹膜转移 | 无=0,有=1 |
PD-L1 mRNA相对表达量 | 低水平=0,高水平=1 |
CD8+ TILs密度 | 高密度=0,低密度=1 |
预后 | 良好=0,不良=1 |
变量 | 单因素Cox回归分析 | 多因素Cox回归分析 | ||||||||
---|---|---|---|---|---|---|---|---|---|---|
β | SE | Wald χ2值 | P值 | HR(95%CI) | β | SE | Wald χ2值 | P值 | HR(95%CI) | |
年龄 | 0.425 | 0.299 | 2.012 | 0.014 | 1.452(1.087,3.256) | 0.635 | 0.678 | 0.878 | 0.076 | 1.032(0.847,1.415) |
性别 | 0.859 | 0.707 | 1.475 | 0.087 | 1.526(0.895,1.854) | — | — | — | — | — |
手术类型 | -1.230 | 0.562 | 4.790 | 0.105 | 0.814(0.725,1.024) | — | — | — | — | — |
分化程度 | -0.474 | 0.466 | 1.036 | 0.074 | 0.698(0.529,1.241) | — | — | — | — | — |
浸润深度 | 2.147 | 0.611 | 12.362 | <0.001 | 11.458(3.584,21.021) | 2.047 | 0.640 | 10.215 | <0.001 | 8.256(2.367,15.021) |
淋巴结转移 | 0.356 | 0.320 | 1.236 | 0.085 | 1.104(0.896,1.352) | — | — | — | — | — |
脉管侵犯 | 3.521 | 0.900 | 15.326 | <0.001 | 8.145(3.625,14.363) | 3.605 | 1.012 | 12.682 | <0.001 | 6.150(3.071,12.063) |
腹膜转移 | 2.241 | 0.817 | 7.526 | 0.004 | 3.452(1.632,8.635) | 2.307 | 0.839 | 7.526 | 0.017 | 2.856(1.418,6.328) |
PD-L1 mRNA相对表达量 | 3.251 | 1.576 | 5.263 | 0.008 | 4.256(1.625,6.302) | 1.632 | 0.705 | 5.362 | 0.020 | 3.021(1.632,5.045) |
CD8+ TILs密度 | 2.306 | 1.207 | 3.652 | 0.015 | 3.652(1.147,5.065) | 2.149 | 0.941 | 5.214 | 0.032 | 2.158(1.854,4.632) |
Table 3 Univariate and multivariate Cox regression analysis of factors affecting prognosis of patients with gastric cancer
变量 | 单因素Cox回归分析 | 多因素Cox回归分析 | ||||||||
---|---|---|---|---|---|---|---|---|---|---|
β | SE | Wald χ2值 | P值 | HR(95%CI) | β | SE | Wald χ2值 | P值 | HR(95%CI) | |
年龄 | 0.425 | 0.299 | 2.012 | 0.014 | 1.452(1.087,3.256) | 0.635 | 0.678 | 0.878 | 0.076 | 1.032(0.847,1.415) |
性别 | 0.859 | 0.707 | 1.475 | 0.087 | 1.526(0.895,1.854) | — | — | — | — | — |
手术类型 | -1.230 | 0.562 | 4.790 | 0.105 | 0.814(0.725,1.024) | — | — | — | — | — |
分化程度 | -0.474 | 0.466 | 1.036 | 0.074 | 0.698(0.529,1.241) | — | — | — | — | — |
浸润深度 | 2.147 | 0.611 | 12.362 | <0.001 | 11.458(3.584,21.021) | 2.047 | 0.640 | 10.215 | <0.001 | 8.256(2.367,15.021) |
淋巴结转移 | 0.356 | 0.320 | 1.236 | 0.085 | 1.104(0.896,1.352) | — | — | — | — | — |
脉管侵犯 | 3.521 | 0.900 | 15.326 | <0.001 | 8.145(3.625,14.363) | 3.605 | 1.012 | 12.682 | <0.001 | 6.150(3.071,12.063) |
腹膜转移 | 2.241 | 0.817 | 7.526 | 0.004 | 3.452(1.632,8.635) | 2.307 | 0.839 | 7.526 | 0.017 | 2.856(1.418,6.328) |
PD-L1 mRNA相对表达量 | 3.251 | 1.576 | 5.263 | 0.008 | 4.256(1.625,6.302) | 1.632 | 0.705 | 5.362 | 0.020 | 3.021(1.632,5.045) |
CD8+ TILs密度 | 2.306 | 1.207 | 3.652 | 0.015 | 3.652(1.147,5.065) | 2.149 | 0.941 | 5.214 | 0.032 | 2.158(1.854,4.632) |
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