Abstract: Background　Lipid accumulation product （LAP） and visceral fat index （VAI） are important indicators that reflect the body fat distribution and the degree of visceral fat accumulation，which are closely connected to obesity-related chronic metabolic diseases. Objective　To explore the correlation of LAP and VAI with adult metabolic syndrome （MS），and to evaluate the predictive value of them for MS. Methods　Participants were 708 physical examinees who were recruited from Physical Examination Center，China-Japan Friendship Hospital from September 2018 to May 2019，including 249 with MS，and 459 without. LAP，VAI and physical and biochemical indicators were compared between by MS and non-MS participants. Then the prevalence of MS and its components was compared between LAP quartile groups（177 cases in each group） and between VAI quartile groups（177 cases in each group）. Multivariate Logistic regression was used to estimate the association of LAP and VAI with MS. Sex-specific analysis using the ROC curve was performed to measure the predictive value of LAP，VAI，waist circumference and body mass index for adult MS. Results　LAP and VAI were highly positively correlated with MS prevalence （Cramer's V=0.585，0.577）. Multivariate Logistic regression analysis showed that after adjusting for various risk factors，the risk of MS in the third or fourth quartile of LAP was still statistically higher than that of the first quartile of LAP（P<0.001）. And MS risk in the third or fourth quartile of VAI was still statistically higher than that of the first quartile of VAI （P<0.001）. ROC analysis showed that in predicting the risk of MS in men，the AUC of LAP was 0.831〔95%CI（0.795，0.867）〕with a cutoff point of 52.03，and the AUC of VAI was 0.825〔95%CI（0.788，0.863）〕 with a cutoff point of 1.99. As for predicting the risk of MS in women，the AUC of LAP was 0.887〔95%CI（0.834，0.940）〕 with a cutoff point of 54.84，and that of VAI was 0.886〔95%CI（0.827，0.945）〕with a cutoff point of 2.54. Conclusion　Both LAP and VAI were highly positively correlated with adult MS，indicating that the risk of MS increased with the growth of LAP and VAI. Since LAP and VAI demonstrated good predictive value for MS，their combination with waist circumference and body mass index may effectively screen MS.

Key words: Metabolic syndrome, Lipid accumulation product, Visceral fat index, Correlation, Predictive value

摘要： 背景　脂质蓄积指数（LAP）和内脏脂肪指数（VAI）是反映个体脂肪分布及内脏脂肪蓄积程度的重要指标，与肥胖相关的慢性代谢性疾病关系密切。目的　探讨LAP和VAI与成年人代谢综合征（MS）的相关性，并评估LAP、VAI对MS的预测价值。方法　纳入2018年9月至2019年5月在中日友好医院体检中心进行体检的708例受试者，其中MS患者249例（MS组），非MS患者459例（非MS组），比较两组患者LAP、VAI及相关生化指标。根据LAP、VAI四分位数将受试者进行分组（L1组、L2组、L3组、L4组各177例；V1组、V2组、V3组、V4组各177例），比较各组MS及其组分发生率。采用多因素Logistic回归分析计算不同LAP、VAI受试者MS的发生风险，并分别绘制不同性别LAP、VAI、腰围（WC）、体质指数（BMI）预测MS发生风险的受试者工作特征（ROC）曲线。结果　LAP和VAI与成年人MS发生率呈高强度正相关（Cramer's V=0.585、0.577）。多因素Logistic回归分析结果显示，在调整各危险因素后，L3组、L4组MS发生风险仍高于L1组，V3组、V4组MS发生风险仍高于V1组（P<0.001）。ROC曲线分析结果显示，男性LAP、VAI预测MS发生风险的ROC曲线下面积（AUC）分别为0.831〔95%CI（0.795，0.867）〕、0.825〔95%CI（0.788，0.863）〕，临界值分别为52.03、1.99；女性LAP、VAI预测MS发生风险的AUC分别为0.887〔95%CI（0.834，0.940）〕、0.886〔95%CI（0.827，0.945）〕，临界值分别为54.84、2.54。结论　LAP、VAI与成年人MS发生率呈高强度正相关，随着LAP、VAI增高，MS发生风险亦增高；LAP、VAI对MS有良好的预测价值，联合WC和BMI能有效预测MS。

关键词: 代谢综合征, 脂质蓄积指数, 内脏脂肪指数, 相关性, 预测价值