Abstract: Background　Sleep disorder has become a common health issue in chronic anemia patients，and its induced impaired sleep quality may increase the level of anxiety and decrease the recovery of anemia symptoms.Drug therapy can improve sleep quality，but has a series of side effects.So nonpharmacological interventions for improving sleep quality has obtained increasing attentions from medical professionals.However，there is no enough clinical evidence that demonstrates whether the use of electrostatic acupoint plaster （EAP） cranial electrotherapy stimulation（CES） can improve the quality of sleep and efficacy of anemia treatment in this population.Objective　To explore the effect of EAP CES therapy on the sleep quality and symptom distress of chronic anemia patients.Methods　A total of 96 chronic anemia patients treated in General Practice Department，the Affiliated Hospital of Hangzhou Normal University were enrolled from November 2018 to January 2019，and were randomized into intervention group and control group with 48 cases in each.Both groups received routine therapy，the intervention group received EAP CES treatment for 8 weeks additionally.The sleep quality and symptom distress of the two groups were compared by the results measured by the improved Pittsburg Sleep Quality Index （PSQI） before and after the intervention.Results　There were no significant differences in the pre-intervention global and each component scores of the improved PSQI between the two groups （P>0.05）.After the intervention，no significant changes were found in the average global and component scores of the improved PSQI in the control group（P>0.05），but in the intervention group，except the average score of cough or snore loudly almost remained the same（P>0.05），obvious declines were found in the average global score of improved PSQI，and the average scores of bed time，hours of sleep per night，wake up easy and early，frequent urination，feel too cold and hot，had bad dreams，take medicine to help sleep，daytime sleepiness，and daytime energy deficiency（P<0.05）.In comparison with the control group，the intervention group showed lower post-intervention average global score of improved PSQI，and lower average scores of bed time，hours of sleep per night，wake up easy and early，frequent urination，feel too cold and hot，had bad dreams，take medicine to help sleep，daytime sleepiness，and daytime energy deficiency（P<0.05），but similar average score of cough or snore loudly（P>0.05）.There was no significant intergroup difference in the incidence of anemia symptoms before intervention （P>0.05），but the intervention group showed lower incidence of daytime sleepiness，fatigue，dizziness，palpitation，shortness of breath and anorexia after intervention （P<0.05）.Conclusion　EAP CES treatment may help to effectively improve sleep quality and anemia symptoms in patients with chronic anemia.

Key words: Anemia, Sleep disorders, Acupoint sticking therapy, Cranial electrotherapy stimulation, Signs and symptoms

摘要： 背景　睡眠障碍已成为慢性贫血患者普遍存在的健康问题。低质量的睡眠不仅会增加贫血患者的焦虑，而且影响贫血症状恢复。药物治疗可以促进睡眠质量改善，但也存在一定的不良反应。因此，采用非药物疗法干预睡眠障碍的效果越来越得到医学界重视。目前静电敷贴经颅微电流刺激（CES）能否改善贫血患者的睡眠质量，增加贫血治疗效果尚无充足临床证据支持。目的　探讨静电敷贴CES对慢性贫血患者睡眠质量和贫血症状的影响。方法　选取2018年11月—2019年1月在杭州师范大学附属医院全科医学门诊诊治的96例慢性贫血伴睡眠障碍患者为研究对象，采用随机数字表法将其分为干预组和对照组，每组48例。对照组仅接受常规贫血治疗，干预组在接受常规贫血治疗的基础上再接受静电敷贴CES治疗，两组各干预8周。干预前及干预后采用改良匹兹堡睡眠质量指数量表（PSQI）评价两组睡眠质量，统计患者贫血症状发生率。结果　干预前两组患者改良PSQI总分及各条目得分比较，差异无统计学意义（P>0.05）。干预后干预组入睡时间、睡眠时间、易醒或早醒、尿频、冷热感觉、噩梦、催眠药物使用、日间困倦感、日间精力不足得分及改良PSQI总分均低于对照组（P<0.05）；两组咳嗽或鼾声高得分比较，差异无统计学意义（P>0.05）。对照组患者干预前后改良PSQI总分及各条目得分比较，差异无统计学意义（P>0.05）。干预组干预后入睡时间、睡眠时间、易醒或早醒、尿频、冷热感觉、噩梦、催眠药物使用、日间困倦感、日间精力不足得分及改良PSQI总分均低于干预前（P<0.05）；干预前后咳嗽或鼾声高得分比较，差异无统计学意义（P>0.05）。两组干预前贫血症状发生率比较，差异无统计学意义（P>0.05）。干预后，干预组日间嗜睡、体倦乏力、头昏眼花、心悸气短、食欲不振发生率低于对照组（P<0.05）。结论　静电敷贴CES可能改善慢性贫血患者睡眠质量，减轻贫血症状。

关键词: 贫血, 睡眠障碍, 穴位贴敷法, 静电敷贴, 体征和症状