Abstract: With the changes in living standards and dietary structure，the incidence of hyperuricemia is on the rise.Epidemiological studies show that the prevalence of hyperuricemia in adults is 8.4% - 13.3% in China.A large number of studies have shown that hyperuricemia is not only the main cause of gout，but also an independent risk factor for the progression of chronic kidney disease（CKD） and cardiovascular death.It has become one of the metabolic diseases that threaten human health.Mineral and bone disorder are common complications of CKD，including mineral metabolism disorders，bone lesions and extra-osseous calcification，which can lead to increased hospitalization，cardiovascular events and mortality in patients with CKD.Recent studies have found uric acid may be closely related to CKD-mineral and bone disorder （CKD-MBD），but the correlation is still controversial and further researches are needed.This article reviews the pathophysiological function of uric acid，the relationship between uric acid and CKD-MBD and the recent advances of their interaction mechanism.It is suggested that the regulation of uric acid level may be the target of CKD-MBD therapy.

Key words: Uric acid, Chronic kidney disease, Mineral and bone disorder, Review

摘要： 随着生活水平和饮食结构的改变，高尿酸血症的发病率呈不断上升趋势，流行病学调查显示，我国成年人高尿酸血症的患病率为8.4%~13.3%，高尿酸血症不仅是痛风的主要病因，而且是慢性肾脏病（CKD）进展和心血管疾病死亡的独立危险因素，已经成为威胁人类健康的代谢性疾病之一。矿物质和骨代谢异常（MBD）是CKD常见的并发症，其包括矿物质代谢紊乱、骨骼病变和骨外钙化，可导致CKD患者住院率、心血管事件及死亡率增加。近年研究发现尿酸与CKD-MBD之间可能密切相关，但其相关性目前仍存在争议，尚需深入研究论证。本文综述了尿酸的病理生理功能、尿酸与CKD-MBD的关系及相互作用机制的研究进展，认为调控尿酸水平可能成为CKD-MBD治疗的靶点。

关键词: 尿酸, 慢性肾脏病, 矿物质和骨代谢异常, 综述