Research Progress in Improving the Treatment Compliance of Tuberculosis Patients with the Utilization of New Technologies

doi:10.12114/j.issn.1007-9572.2019.00.361

Abstract

Abstract: Improving the treatment compliance of tuberculosis（TB） patients is one of the most effective public health measures to cut down the spread of TB and control its prevalence.Therefore，Directly Observed Treatment（DOT） is recommended by the World Health Organization（WHO），but it is difficult to be implemented because of the serious shortage of health workers and inconvenient transportation.At present，various new technologies（such as smart phones，mobile networks and satellite communications） breaks the limitations of traditional medical behaviors and patterns by time and space，and are widely used in the management of TB patients.In order to provide the basis for popularizing the usage of related new technologies and improving the treatment compliance of TB patients，this paper reviews the intervention forms and effects and health workers and patients experience of using these new technologies to improve the treatment compliance of TB patients at home and abroad.

Key words: Computer communication networks, Tuberculosis, Medication adherence, Review

摘要： 提高结核病患者治疗依从性是减少结核病传播、控制结核病流行有效公共卫生措施之一。世界卫生组织（WHO）推荐以医务人员为主的直接面视下治疗（DOT），但在落实中存在医务人员严重缺乏、交通不便等困难。目前，利用新技术（如智能手机、移动网络、卫星通信等）提供医疗服务和信息，打破了传统医疗行为与模式受时间和空间的限制，被广泛应用于结核患者治疗依从性的管理中。本文综述了国内外相关新技术在结核病患者治疗依从性中应用的干预形式、干预效果、医务人员和患者的使用体会，以期为我国推广相关新技术的使用、改善结核病患者的治疗依从性提供依据。

关键词: 计算机通信网络, 结核, 服药依从性, 综述

ZHANG Jinjing,YANG Yunyun,PENG Dali. Research Progress in Improving the Treatment Compliance of Tuberculosis Patients with the Utilization of New Technologies　[J]. Chinese General Practice, 2020, 23(1): 114-119. DOI: 10.12114/j.issn.1007-9572.2019.00.361.
张金静,杨云云,彭大利. 利用新技术提高结核病患者治疗依从性的研究进展[J]. 中国全科医学, 2020, 23(1): 114-119. DOI: 10.12114/j.issn.1007-9572.2019.00.361.

References

［1］World Health Organization．Global tuberculosis report 2016［R］．Geneva：World Health Organization，2017：12.
［2］林定文．肺结核患者治疗依从性研究进展［J］．热带医学杂志，2014，14（7）：973-975．http://www.wanfangdata.com.cn/details/detail.do?_type=perio&id=rdyxzz201407042.
［3］KARUMBI J，GARNER P．Directly observed therapy for treating tuberculosis［J］．Cochrane Database Syst Rev，2015，29（5）：CD003343．DOI：10.1002/14651858.CD003343.pub4.
［4］VAN DEN B J，LYIMO R A，BOEREE M J，et al．Electronic monitoring of treatment adherence and validation of alternative adherence measures in tuberculosis patients：a pilot study［J］．B World Health Organ，2011，89（9）：632-639．DOI：10.2471/BLT.11.086462.
［5］马艳，杜建，刘宇红，等．移动医疗在结核病患者管理中的作用［J］．中国防痨杂志，2016，38（7）：527-530．DOI：10.3969/j.issn.1000-6621.
MA Y，DU J，LIU Y H，et al．The role of mobile health on management of tuberculosis patients［J］．Chin J Antituberc，2016，38（7）：527-530．DOI：10.3969/j.issn.1000-6621.
［6］CHUCK C，ROBINSON E，MACARAIG M，et al．Enhancing management of tuberculosis treatment with video directly observed therapy in New York City［J］．Int J Tuberc Lung Dis，2016，20（5）：588-593．DOI：10.5588/ijtld.15.0738.
［7］ARANDA-JAN C B，MOHUTSIWA-DIBE N，LOUKANOVA S.Systematic review on what works，what does not work and why of implementation of mobile health（mHealth） projects in Africa［J］．BMC Public Health，2014，14：188．DOI：10.1186/1471-2458-14-1881471-2458-14-188.
［8］SILVA B M，RODRIGUES J J，DELA T D I，et al．Mobile-health：a review of current state in 2015［J］．J Biomed Inform，2015，56：265-272．DOI：10.1016/j.jbi.2015.06.003S1532-0464（15）00113-6.
［9］赵蓉蓉，陈素艳.移动医疗在肺结核患者管理中的应用研究进展［J］．中国防痨杂志，2018，40（3）：325-327．DOI：10.3969/j.issn.1000-6621.
ZHAO R R，CEHN S Y．The research progress on the application of mobile medical treatment in tuberculosis management［J］．Chin J Antituberc，2018，40（3）：325-327．DOI：10.3969/j.issn.1000-6621.
［10］MOHAMMED S，GLENNERSTER R，KHAN A J．Impact of a daily SMS medication reminder system on tuberculosis treatment outcomes：a randomized controlled trial［J］．PLoS One，2016，11（11）：e0162944．DOI：10.1371/journal.pone.0162944.
［11］MOHAMMED S，SIDDIQI O，ALI O，et al．User engagement with and attitudes towards an interactive SMS reminder system for patients with tuberculosis［J］．J Telemed Telecare，2012，18（7）：404-408．DOI：10.1258/jtt.2012.120311.
［12］BEDIANG G，STOLL B，ELIA N，et al．SMS reminders to improve adherence and cure of tuberculosis patients in Cameroon （TB-SMS Cameroon）：a randomised controlled trial［J］．BMC Public Health，2018，18（1）：583．DOI：10.1186/s12889-018-5502-x.
［13］BEDIANG G，STOLL B，ELIA N，et al．SMS reminders to improve the tuberculosis cure rate in developing countries （TB-SMS Cameroon）：a protocol of a randomised control study［J］．Trials，2014，15：35．DOI：10.1186/1745-6215-15-35.
［14］LIU X Q，LEWIS J J，ZHANG H，et al．Effectiveness of electronic reminders to improve medication adherence in tuberculosis patients：a cluster-randomised trial［J］．PLoS Med，2015，12（9）：e1001876．DOI：10.1371/journal.pmed.1001876.
［15］梁大斌，黄敏莹，刘飞鹰，等．应用手机短信对肺结核患者治疗管理的效果研究［J］．现代预防医学，2018，45（5）：847-882．
LIANG D B，HUANG M Y，LIU F Y，et al．Effect of text message to enhance the management of pulmonary tuberculosis patients［J］．Modern Preventive Medicine，2018，45（5）：847-882．
［16］肖力，黄亚菊.短信随访对提高肺结核病人依从性和治愈率的研究［J］．护士进修杂志，2014，29（24）：2289-2291．DOI：10.16821/j.cnki.hsjx.2014.24.033.
XIAO L，HUANG Y J．Study on SMS to improve the compliance and cure rate of tuberculosis patients［J］．J Nurs Train，2014，29（24）：2289-2291．DOI：10.16821/j.cnki.hsjx.2014.24.033.
［17］HOFFMAN J A，CUNNINGHAM J R，SULEH A J，et al．Mobile direct observation treatment for tuberculosis patients：a technical feasibility pilot using mobile phones in Nairobi，Kenya［J］．Am J Prev Med，2010，39（1）：78-80．DOI：10.1016/j.amepre.
［18］DISTEFANO M J，SCHMIDT H.MHealth for tuberculosis treatment adherence：a framework to guide ethical planning，implementation，and evaluation［J］．Glob Health Sci Pract，2016，4（2）：211-221．DOI：10.9745/GHSP-D-16-00018.
［19］STORY A，GARFEIN R S，HAYWARD A，et al．Monitoring therapy compliance of tuberculosis patients by using video-enabled electronic devices［J］．Emerg Infect Dis，2016，22（3）：538-540．DOI：10.3201/eid2203.151620.
［20］MIRSAEIDI M，FARSHIDPOUR M，BANKS-TRIPP D，et al．Video directly observed therapy for treatment of tuberculosis is patient-oriented and cost-effective［J］．Eur Respir J，2015，46（3）：871-874．DOI：10.1183/09031936.00011015.
［21］GARFEIN R S，COLLINS K，MUNOZ F，et al．Feasibility of tuberculosis treatment monitoring by video directly observed therapy：a binational pilot study［J］．Int J Tuberc Lung Dis，2015，19（9）：1057-1064．DOI：10.5588/ijtld.14.0923.
［22］NGUYEN T A，PHAM M T，NGUYEN T L，et al．Video directly observed therapy to support adherence with treatment for tuberculosis in Vietnam：a prospective cohort study［J］．Int J Infect Dis，2017，65：85-89．DOI：10.1016/j.ijid.
［23］HOLZMAN S B，ZENILMAN A，SHAH M．Advancing patient-centered care in tuberculosis management：a mixed-methods appraisal of video directly observed therapy［J］．Open Forum Infect Dis，2018，5（4）：ofy046．DOI：10.1093/ofid/ofy046.
［24］钟道临，黄惠安，刘桂芬，等．网络视频直视下督导服药在结核病防治中的应用［J］．中国医学工程，2012，20（4）：143-145.
ZHONG D L，HUANG H A，LIU G F，et al．Application of video directly therapy on the prevention and treatment of tuberculosis［J］．China Medical Engineering，2012，20（4）：143-145.
［25］房宏霞，秦玉宝，刘昌伟，等．互联网+手机视频督导在结核病患者治疗管理中应用情况的初步分析［J］．中国防痨杂志，2017，39（7）：684-688．DOI：10.3969/j.issn.1000-6621.
FAGN H X，QIN Y B，LIU C W，et al．Prelininary analysis of video observed therapy for management of tuberculosis patients by internet and moblile phones in Longhua District of Shenzhen City［J］．Chin J Antituberc，2017，39（7）：684-688．DOI：10.3969/j.issn.1000-6621.
［26］WADE V A，KARNON J，ELIOTT J A，et al．Home videophones improve direct observation in tuberculosis treatment：a mixed methods evaluation［J］．PLoS One，2012，7（11）：e50155．DOI：10.1371/journal.pone.0050155.
［27］ELANGOVAN R，ARULCHELVAN S．A study on the role of mobile phone communication in tuberculosis DOTS treatment［J］．Indian J Community Med，2013，38（4）：229-233．DOI：10.4103/0970-0218.120158.
［28］高丽，钱秀娟，黄双燕，等．传统督导和电话督导对县及乡镇肺结核患者治疗依从性的影响［J］．国际流行病学传染病学杂志，2016，43（6）：404-407．DOI：10.3760/cma.j.issn.1673-4149.
GAO L，QIAN X J，HUANG S Y，et al．The effect of traditional supervision and telephone supervision on treatment compliance of tuberculosis patients in county and township［J］．Inter J Epidemiol Infect Dis，2016，43（6）：404-407．DOI：10.3760/cma.j.issn.1673-4149.
［29］钱惠军，步佳佳.出院电话随访对肺结核患者服药依从性的影响［J］．当代护士，2018，25（2）：124-125．http://d.old.wanfangdata.com.cn/Periodical/ddhs-xsb201802056.
［30］李腊梅，王晓燕，马小绒．电话随访对出院肺结核患者治疗依从性和生活质量的影响［C］．长沙：湖南中医药大学期刊杂志社，2016.
［31］翟广．电话随访对出院后肺结核患者治疗依从性的影响［J］．中国实用医药，2012，7（28）：249-250．DOI：10.14163/j.cnki.11-5547/r.2012.28.070.
ZHAI G．Effect of telephone follow-up on treatment compliance of post-discharge tuberculosis patients［J］．China Prc Med，2012，7（28）：249-250．DOI：10.14163/j.cnki.11-5547/r.2012.28.070.
［32］GUIX-COMELLAS E M，ROZAS-QUESADA L，FORCE-SANMARTIN E，et al．Influence of nursing interventions on adherence to treatment with antituberculosis drugs in children and young people：research protocol［J］．J Adv Nurs，2015，71（9）：2189-2199．DOI：10.1111/jan.12656.
［33］原国家卫生计生委办公厅.关于印发结核病患者健康管理服务规范的通知［EB/OL］．（2015-10-02）［2019-05-24］．http：//www.nhc.gov.cn/jws/s3577/201510/3658751de5ce4d70a4cfe3536b856f44.shtml.
［34］LEWIS J J，LIU X，ZHANG Z，et al．Evaluation of a medication monitor-based treatment strategy for drug-sensitive tuberculosis patients in China：study protocol for a cluster randomised controlled trial［J］．Trials，2018，19（1）：398．DOI：10.1186/s13063-018-2650-3.
［35］MADYO D D．Investigating user acceptability and effectiveness of the SIMpill device as a strategy to improve treatment adherence among TB patients enrolled in the SIMpill project：a pilot study in the Frances Baard District，Northern Cape Province［D］．Limpopo：University of Limpopo，2010：27.
［36］DE SUMARI-DE B I M，VAN DEN B J，NGOWI K M，et al．Feasibility of real time medication monitoring among HIV infected and TB patients in a resource-limited setting［J］．AIDS Behav，2016，20（5）：1097-1107．DOI；10.1007/s10461-015-
1254-0.
［37］AU-YEUNG K Y，DICARLO L．Cost comparison of wirelessly vs. directly observed therapy for adherence confirmation in anti-tuberculosis treatment［J］．Int J Tuberc Lung Dis，2012，16（11）：1498-1504．DOI：10.5588/ijtld.11.0868.
［38］BELKNAP R，WEIS S，BROOKENS A，et al．Feasibility of an ingestible sensor-based system for monitoring adherence to tuberculosis therapy［J］．PLoS One，2013，8（1）：e53373．DOI：10.1371/journal.pone.0053373.
［39］AU-YEUNG K Y，DICARLO L．Cost comparison of wirelessly vs. directly observed therapy for adherence confirmation in anti-tuberculosis treatment［J］．Int J Tuberc Lung Dis，2012，16（11）：1498-1504．DOI：10.5588/ijtld.11.0868.
［40］解艳涛，杜建，罗萍，等．2016年北京市通州区结核病患者移动督导管理应用程序使用情况初步报告［J］．中国防痨杂志，2017，39（7）：708-712．DOI：10.3969/j.issn.1000-6621.
XIE Y T，DU J，LUO P，et al．Preliminary report of a mobile supervision application used for treatment management in patients with tuberculosis in Tongzhou District，Beijing in 2016［J］．Chin J Antituberc，2017，39（7）：708-712．DOI：10.3969/j.issn.1000-6621.
［41］NGLAZI M D，BEKKER L G，WOOD R，et al．Mobile phone text messaging for promoting adherence to anti-tuberculosis treatment：a systematic review［J］．BMC Infect Dis，2013，13：566．DOI：10.1186/1471-2334-13-566.
［42］WINARTO A，BINTORO T．Analysis of the effect telephone counseling by nurses on the compliance of the control of dots poly tuberculosis patients at dungus madiun lung hospital［J］．J Nurs Prac，2018，1（2）：47-52．DOI：10.30994/jnp.v1i2.33.
［43］徐红，陆峰．运用电子药盒管理肺结核患者依从性分析［J］．江苏预防医学，2013，24（1）：51-52．DOI：10.3969/j.issn.1006-9070.2013.01.023．http://d.old.wanfangdata.com.cn/Periodical/jsyfyx201301023．
［44］ALBINO S，TABB K M，REQUENA D，et al．Perceptions and acceptability of short message services technology to improve treatment adherence amongst tuberculosis patients in Peru：a focus group study［J］．PLoS One，2014，9（5）：e95770．DOI：10.1371/journal.pone.0095770.
［45］IRIBARREN S J，SWARD K A，BECK S L，et al．Qualitative evaluation of a text messaging intervention to support patients with active tuberculosis：implementation considerations［J］．JMIR Mhealth Uhealth，2015，3（1）：e21．DOI：10.2196/mhealth.3971.
［46］HOLZSCHUH E L，PROVINCE S，JOHNSON K，et al．Use of video directly observed therapy for treatment of latent tuberculosis infection-Johnson County，Kansas，2015［J］．Morb Mortal Wkly Rep，2017，66（14）：387-389．DOI：10.15585/mmwr.mm6614a3.
［47］SUNYAEV A，DEHLING T，TAYLOR P L，et al．Availability and quality of mobile health app privacy policies［J］．J Am Med Inform Assoc，2015，22（1）：28-33．DOI；10.1136/amiajnl-2013-002605.

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