Abstract: Objective　To summarize the clinical features and laboratory results of incomplete Kawasaki disease （IKD） in children，providing evidence for early clinical recognition，diagnosis and prognosis improvement of this disease.Methods　We enrolled 94 children with IKD who received inpatient treatment in Department of Pediatrics，Wuhan No.1 Hospital from July 2016 to July 2018 in accordance with the inclusion criteria of this study，including 53 with typical KD（typical KD group），and 41 with atypical KD（IKD group）．Through the His system of the hospital，we collected and retrospectively analyzed their clinical data，including sex，age，clinical manifestations（fever interval before diagnosis，bulbar conjunctival congestion，chapped lips，strawberry tongue，fingernail and toenail shedding，perianal desquamation，rash，cervical lymphadenopathy，redness and swelling of the BCG vaccination scar），laboratory results during the acute stage of KD 〔erythrocyte sedimentation rate，C-reactive protein （CRP），white blood cell count，hemoglobin，neutrophil percentage （N%），platelet count，serum albumin，A/G ratio，AST，ALT，CK-MB 〕，and results of etiology detection，echocardiography and electrocardiogram（ECG）．Results　Two groups had no significant differences in sex ratio （χ2 =0.106，P>0.05） and age distribution（Z=-1.760，P>0.05）．Compared with typical KD group，IKD group demonstrated longer average fever interval before diagnosis，lower rates of chapped lips，fingernail and toenail shedding，perianal desquamation，rash，and cervical lymphadenopathy，higher rate of redness and swelling of the BCG vaccination scar，and lower average levels of CRP and N% at the acute stage of KD（P<0.05）．Among the typical KD group，there were 19 cases （35.9%） with clear etiologies，including 6 cases of viral infection，5 cases of bacterial infection，5 cases of Mycoplasma infection and 3 cases of mixed bacterial and viral infection，and in IKD group，there were 22 cases （53.7%） with clear etiologies，including 9 cases of Mycoplasma infection，6 cases of bacterial infection，5 cases of viral infection，and 2 cases of mixed bacterial and viral infection，indicating there was no significant difference in the incidence of pathogenic infection between the groups （χ2 = 2.981，P>0.05）．The incidence of coronary artery dilatation in IKD group was higher than that of typical KD group （P<0.05）．Conclusion　IKD was associated with longer fever interval，higher possibilities of having redness and swelling of the BCG vaccination scar，and coronary artery dilatation，but not associated with noticeable clinical manifestations.If children are found with the above-mentioned symptoms，IKD should be suspected，and inflammatory marker test should be performed as soon as possible，in order to obtain a definite diagnosis early.

Key words: Mucocutaneous lymph node syndrome, Clinical manifestations, Coronary damage, Fever

摘要： 目的　总结不完全川崎病（IKD）的临床特点及实验室检查结果，为临床早期识别、早期诊断提供依据，以改善患儿预后。方法　收集2016年7月—2018年7月在武汉市第一医院儿科住院的符合研究标准的94例川崎病（KD）患儿的临床资料，其中典型KD患儿53例（典型KD组），IKD患儿41例（IKD组）。通过医院His系统查询患儿病历信息，回顾性分析KD患儿的性别、年龄、临床表现〔确诊前发热时间、球结膜充血情况、口唇皲裂情况、杨梅舌情况、指（趾）端蜕皮情况、肛周脱屑情况、皮疹情况、颈部淋巴结肿大情况、卡疤红肿情况〕、急性期实验室检查〔红细胞沉降率（ESR）、C反应蛋白（CRP）、白细胞计数（WBC）、血红蛋白（Hb）、中性粒细胞分数（N%）、血小板计数（PLT）、血清清蛋白（ALB）、白球比例（A/G）、天冬氨酸氨基转移酶（AST）、丙氨酸氨基转移酶（ALT）、肌酸激酶同工酶（CK-MB）〕、病原体感染情况、心脏彩超检查情况、心电图检查情况。结果　两组患儿性别、年龄比较，差异无统计学意义（χ2=0.106，Z=-1.760，P均>0.05）。IKD组患儿确诊前发热时间长于典型KD组（P<0.05）；IKD组患儿口唇皲裂、指（趾）端蜕皮、肛周脱屑、皮疹、颈部淋巴结肿大发生率低于典型KD组（P<0.05）；IKD组患儿卡疤红肿发生率高于典型KD组（P<0.05）。典型KD组患儿急性期CRP、N%高于IKD组（P<0.05）。典型KD组患儿中，明确病原体感染患儿共19例（35.9%），其中病毒感染6例，细菌感染5例，支原体感染5例，细菌病毒混合感染3例；IKD组患儿中，明确病原体感染患儿共22例（53.7%），其中支原体感染9例，细菌感染6例，病毒感染5例，细菌病毒混合感染2例；两组患儿病原体感染发生率比较，差异无统计学意义（χ2=2.981，P>0.05）。IKD组患儿冠状动脉扩张发生率高于典型KD组（P<0.05）。结论　IKD患儿发热时间长，易出现卡疤红肿，且冠状动脉扩张发生率较高，但主要临床症状表现不明显；临床如发现上述症状患儿，应警惕IKD的可能，尽早完善实验室相关炎性指标的检查。

关键词: 黏膜皮肤淋巴结综合征, 临床表现, 冠状动脉损害, 发热