Abstract: Objective　To analyze gender-specific differences in clinical characteristics and laboratory results of psoriasis arthritis（PsA）．Methods　This study was conducted following a retrospective design.Participants were 215 cases of PsA who received inpatient treatment from General Hospital of Ningxia Medical University during April 2007 to April 2017.A sex-specific analysis was performed on clinical and laboratory data such as initial manifestations，skin lesion distribution，type of PsA，joint involvement，system involvement，and immunology and inflammatory indicators.Results　Among the 215 patients，the number of males and females was 118，and 97，respectively，with a male to female ratio of 1.22∶1.There were no significant differences in the incidence of arthritis，skin lesions，arthritis and skin lesions as the initial manifestations between males and females（P>0.05）．In terms of skin lesion distribution，the trunk involvement rate of males was lower than that of females〔18.6%（22/118） vs 32.0%（31/97）〕（χ2=5.081，P=0.024）．Both groups showed no significant differences in age of initial onset and course of PsA（P>0.05）．Females showed a higher rate of symmetrical polyarticular type but a lower rate of spondyloarthropathy type than males（P<0.05）．There were no significant gender-specific differences in the rates of asymmetric oligoarticular，distal interphalangeal and mutilative arthritis（P>0.05）．The involvement rates of joints of metacarpophalangeal，ankle，shoulder，knee，wrist and elbow were higher in females（P<0.05），but those of other joints were similar in both groups（P>0.05）．The rate of blood system damage was higher in males（P<0.05），but other rates of lung，heart，eye，and kidney damages were similar in both groups（P>0.05）．Females had a higher rate of ANA titer >1∶100 and higher IgM but a lower rate of HLA-B27（+），and lower levels of IgA，C3，ESR and CRP（P<0.05）．There were no obvious gender-specific differences in the rates of anti-CCP antibody（+），AKA（+），and RF（+），and in the levels of IgG and C4（P>0.05）．Conclusion　Males had a higher prevalence of PsA.The types of PsA，joints and systemic involvement were different between males and females.Male was associated with a higher probability of having HLA-B27（+），and increased IgA，C3，ESR and CRP，while female was associated with a higher probability of having ANA titer > 1∶100 and increased IgM.

Key words: Arthritis, psoriatic；Sex factors；Individuality；Disease attributes

摘要： 目的　探讨不同性别间银屑病关节炎（PsA）患者的临床特征、相关实验室检查结果的差异性。方法　收集2007年4月—2017年4月宁夏医科大学总医院收治的215例PsA患者的住院病历资料，回顾性分析不同性别患者首发症状及皮损分布、关节炎类型、关节累及情况、系统累及情况、免疫学及炎性指标间的差异。结果　215例患者中男118例，女97例，男∶女为1.22∶1。男性与女性患者关节炎首发、皮损首发、关节炎及皮损同时发生的发生率比较，差异均无统计学意义（P>0.05）。皮损分布方面，男性患者躯干累及率为18.6%（22/118），低于女性的32.0%（31/97）（χ2=5.081，P=0.024）。男性与女性患者首发年龄、病程比较，差异无统计学意义（P>0.05）。女性患者对称性多关节炎型发生率高于男性，脊柱关节病型发生率低于男性（P<0.05）；男性与女性患者非对称寡关节炎型、远端指/趾间关节炎型、残毁性关节炎型发生率比较，差异无统计学意义（P>0.05）；女性患者掌指关节、踝关节、肩关节、膝关节、腕关节、肘关节累及率高于男性（P<0.05）；男性与女性患者其他关节累及率比较，差异无统计学意义（P>0.05）。男性患者血液系统损害率高于女性（P<0.05）；男性与女性患者肺脏、心脏、眼部、肾脏损害率比较，差异无统计学意义（P>0.05）。女性患者抗核抗体（ANA）滴度>1∶100发生率、免疫球蛋白M（IgM）高于男性，人类白细胞抗原B27（HLA-B27）（+）发生率、免疫球蛋白A（IgA）、补体C3、红细胞沉降率（ESR）、C反应蛋白（CRP）低于男性（P<0.05）；男性与女性患者抗环瓜氨酸肽抗体（anti-CCP）（+）发生率、抗角蛋白抗体（AKA）（+）发生率、类风湿因子（RF）（+）发生率、免疫球蛋白G（IgG）、补体C4比较，差异无统计学意义（P>0.05）。结论　PsA患者中男性多见，男性与女性间关节炎类型、关节累及情况、系统累及情况均有不同，且在实验室检查方面，男性中HLA-B27（+）发生率、IgA、补体C3、ESR、CRP较高，而女性中ANA滴度>1∶100发生率、IgM较高。

关键词: 关节炎, 牛皮癣；性别因素；个性；疾病特征