Abstract: Alzheimer's disease（AD） is a central nervous system degenerative disease characterized by gradual decline in cognitive and memory performance.Due to unknown etiology and pathogenesis，there is yet no effective medication for AD.Recent studies have proved that resveratrol plays a role in preventing the occurrence and progression of AD.With neuroprotective effect，resveratrol has been confirmed to be effective for improving the memory impairment in animal models of AD，but the mechanism of action is unknown.SIRT1，a regulator of memory performance，can be activated for improving the memory impairment of AD patients by resveratrol.The relevant recent developments were reviewed in this paper，with a view to providing a reference for treating AD with resveratrol.

Key words: Alzheimer disease, Resveratrol, Memory, SIRT1

摘要： 阿尔茨海默病（AD）以进行性认知功能障碍和记忆能力损伤为主，是一种中枢神经系统退行性疾病。由于AD的病因以及发病机制未明，所以尚无有效治疗药物。近年来相关研究表明白藜芦醇可有效预防AD的发生及发展。白藜芦醇具有神经保护作用，可改善AD动物模型记忆能力，但具体机制未明。白藜芦醇可以诱导沉默信息调节因子1（SIRT1），而且SIRT1具有调节记忆能力的作用，故白藜芦醇可能通过激活SIRT1来提高AD患者记忆能力。本文综述白藜芦醇诱导SIRT1改善AD记忆能力的研究进展，为白藜芦醇防治AD提供参考依据。

关键词: 阿尔茨海默病, 白藜芦醇, 记忆, SIRT1