Abstract: Objective　To investigate the relationship between serum 25-（OH）D level and neonatal infectious pneumonia.Methods　The participants were all enrolled from the Second Affiliated Hospital of Zhengzhou University from August 2015 to July 2017，including 65 neonates with infectious pneumonia〔pneumonia group （consisting of 34 with mild infectious pneumonia and 31 with severe infectious pneumonia）〕 from the Neonatal Intensive Care Unit，and 60 healthy neonates （control group）. We compared the levels of serum 25-（OH）D，Ca2+，procalcitonin （PCT），C-reactive protein（CRP），and interleukin-6（IL-6） between the controls and neonates with mild infectious pneumonia and those with severe infectious pneumonia. Spearman's rank correlation analysis was performed to investigate the relationships of 25-（OH）D with Ca2+，PCT，CRP and IL-6 in pneumonia group.Results　Serum Ca2+ level did not differ significantly between the controls and mild and severe infectious pneumonia neonates（P>0.05）. However，serum 25-（OH）D，PCT，CRP and IL-6 varied obviously between them（P<0.05），to be specific，the mild and severe infectious pneumonia neonates had lower serum 25-（OH）D
but higher PCT，CRP and IL-6 levels compared with the controls（P<0.05）；neonates with severe infectious pneumonia demonstrated lower serum 25-（OH）D but higher PCT，CRP and IL-6 levels than those with mild infectious pneumonia（P<0.05）.Among the neonates with infectious pneumonia，serum 25-（OH）D was negatively correlated with PCT and IL-6（rs values were -0.434，-0.315；P<0.05），while showed no correlation with Ca2+ and CRP（rs values were -0.053，-0.184；P>0.05）.Conclusion　Decreased serum 25-（OH）D is found in neonates with infectious pneumonia. Moreover，it declines with the aggravation of the disease.Therefore，monitoring serum 25-（OH）D is contributive to the assessment of the severity of neonatal infectious pneumonia.

Key words: Pneumonia；25-hydroxyvitamin D；Infant, newborn

摘要： 目的　探讨血清25羟维生素D〔25-（OH）D〕水平与新生儿感染性肺炎的关系。方法　选取2015年8月—2017年7月在郑州大学第二附属医院入住新生儿重症监护室的患有感染性肺炎的新生儿65例，根据病情严重程度分为轻症肺炎组34例、重症肺炎组31例；另于同期在本院收集健康新生儿60例为对照组。比较3组血清25-（OH）D、钙离子（Ca2+）、降钙素原（PCT）、C反应蛋白（CRP）、白介素6（IL-6）水平；采用Spearman秩相关分析感染性肺炎患儿血清25-（OH）D水平与血清Ca2+、PCT、CRP、IL-6水平的相关性。结果　3组血清Ca2+水平比较，差异无统计学意义（P>0.05）；3组血清25-（OH）D、PCT、CRP、IL-6水平比较，差异有统计学意义（P<0.05）。其中，轻症肺炎组、重症肺炎组血清25-（OH）D水平低于对照组，血清PCT、CRP、IL-6水平高于对照组，差异有统计学意义（P<0.05）；重症肺炎组血清25-（OH）D水平低于轻症肺炎组，血清PCT、CRP、IL-6水平高于轻症肺炎组，差异有统计学意义（P<0.05）。感染性肺炎患儿的血清PCT、IL-6水平与血清25-（OH）D水平呈负相关（rs值分别为-0.434、-0.315，P<0.05）；血清Ca2+、CRP水平与血清25-（OH）D水平无相关关系（rs值分别为-0.053、-0.184，P>0.05）。结论　感染性肺炎患儿的血清25-（OH）D水平较低，且病情较重者的水平更低，监测血清25-（OH）D水平在新生儿感染性肺炎的病情评估中具有一定临床价值。

关键词: 肺炎, 25羟维生素D, 新生儿