Regulatory Mechanisms and Targeted Therapeutic Research of Mitochondria in Ferroptosis Following Cerebral Hemorrhage

doi:10.12114/j.issn.1007-9572.2024.0645

Abstract

Abstract:

Intracerebral hemorrhage (ICH) is a type of stroke with high mortality and disability rates. Ferroptosis plays a significant role in the secondary injury following ICH. Mitochondria, as the center of cellular metabolism and energy production, has an important role in ferroptosis. Exploring the role of mitochondria in ferroptosis is of great significance for the treatment of secondary injuries after ICH. This article discuss the role of mitochondria in ferroptosis from various aspects, including mitochondrial reactive oxygen species (ROS) and mitochondrial permeability transition pore (mPTP), mitochondrial tricarboxylic acid (TCA) cycle, mitochondrial autophagy, mitochondrial DNA (mtDNA), and mitochondrial dihydroorotate dehydrogenase (DHODH), in the context of ferroptosis following ICH. It also reviews the latest research on targeting mitochondria for the treatment of ferroptosis, providing new insights for the intervention of secondary injuries after ICH.

Key words: Intracerebral hemorrhage, Mitochondria, Ferroptosis, Reactive oxygen species, Mitophagy, Dihydroorotate dehydrogenase

摘要：

脑出血（ICH）是一种高死亡率和致残率的脑卒中类型，铁死亡在ICH后的继发性损伤中扮演重要角色。线粒体作为细胞代谢和能量产生的中心，在铁死亡中具有重要作用，探索线粒体在铁死亡中的作用对治疗ICH后继发性损伤具有重要意义。本文结合ICH后铁死亡过程，从线粒体活性氧（ROS）和线粒体渗透性转换孔（mPTP）、线粒体三羟酸循环（TCA）、线粒体自噬、线粒体脱氧核糖核酸（mtDNA）、线粒体二氢乳清酸脱氢酶（DHODH）等方面探讨其在铁死亡中的作用，并结合靶向线粒体治疗铁死亡的研究进展，为ICH后继发性损伤的干预提供新思路。

关键词: 脑出血, 线粒体, 铁死亡, 活性氧, 线粒体自噬, 二氢乳清酸脱氢酶

CLC Number:

R 743.3

ZHAO Qiyu,LI Xinyue,WU Minmin, et al. Regulatory Mechanisms and Targeted Therapeutic Research of Mitochondria in Ferroptosis Following Cerebral Hemorrhage[J]. Chinese General Practice, 2026, 29(32): 4827-4832. DOI: 10.12114/j.issn.1007-9572.2024.0645.
赵麒羽,李欣悦,吴民民等. 线粒体在脑出血后铁死亡中的调控机制和靶向治疗研究新进展[J]. 中国全科医学, 2026, 29(32): 4827-4832. DOI: 10.12114/j.issn.1007-9572.2024.0645.

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