MetaDTA: an Online Application for Diagnostic Test Accuracy Meta-analysis

doi:10.12114/j.issn.1007-9572.2024.0083

Chinese General Practice ›› 2025, Vol. 28 ›› Issue (08): 1023-1032.DOI: 10.12114/j.issn.1007-9572.2024.0083

• Research Methodology • Previous Articles

MetaDTA: an Online Application for Diagnostic Test Accuracy Meta-analysis

1. Department of Social Science and Health Management, School of Public Health, Lanzhou University, Lanzhou 730000, China
2. Key Laboratory of Evidence Based Medicine of Gansu Province, Lanzhou 730000, China
3. Evidence-based Social Science Research Center, School of Public Health, Lanzhou University, Lanzhou 730000, China
4. Jinan Maternal and Child Health Centre, Jinan 250000, China
5. First Clinical Medical College, Lanzhou University, Lanzhou 730000, China
6. Evidence-based Medicine Center, School of Basic Medical Sciences, Lanzhou University, Lanzhou 730000, China
7. Department of Radiology, the First Hospital of Lanzhou University, Lanzhou 730000, China

Received:2024-03-13 Revised:2024-06-18 Published:2025-03-15 Online:2025-01-02
Contact: NIU Meng, GE Long
About author:
YANG Shuihua and YAO Guiying are co-first authors

MetaDTA：一款诊断试验准确性Meta分析在线应用程序

1．730000　甘肃省兰州市，兰州大学公共卫生学院卫生政策与管理学系
2．730000　甘肃省兰州市，甘肃省循证医学重点实验室
3．730000　甘肃省兰州市，兰州大学循证社会科学研究中心
4．250000　山东省济南市妇幼保健院
5．730000　甘肃省兰州市，兰州大学第一临床医学院
6．730000　甘肃省兰州市，兰州大学基础医学院循证医学中心
7．730000　甘肃省兰州市，兰州大学第一医院放射科

通讯作者: 牛猛, 葛龙
作者简介:
杨水华和姚桂英为共同第一作者
作者贡献：
杨水华查找资料、组织讨论、撰写初稿；姚桂英整理资料、修改论文；晏毅龙、刘嘉艺、王佳佳整理资料、讨论修改；田晨、田金徽、牛猛、葛龙负责论文选题、指导写作、修订稿件、审查论文。
基金资助:
国家自然科学基金资助项目(82204931); 甘肃省教育厅创新基金(2022B-023); 兰州大学第一医院基金(ldyyyn2021-73)

Abstract

Abstract:

MetaDTA is an online, interactive application for Meta-analysis of diagnostic test accuracy studies, which calls on the lme4 and shiny packages in R software to perform the statistical analyses and create an interactive user interface. The application does not require any knowledge of statistics and programming, nor does it require any specialized software to be installed, making it easy to use for users with no specialized statistical knowledge. In this paper, we will focus on the quantification of diagnostic test accuracy, visualisation of results and interactive functions of the MetaDTA platform, and introduce users to the specific operation of the application with examples, aiming to help relevant researchers to complete Meta-analysis of diagnostic accuracy studies, plot summary receiver operating characteristic (SROC) curves, draw the results of the evaluation of the quality of the included studies, and carry out sensitivity analysis.

Key words: MetaDTA, Diagnostic test accuracy, Meta-analysis, Bivariate model

摘要：

MetaDTA是一款对诊断试验准确性研究进行Meta分析的在线、交互式应用程序，该应用程序调用R软件中lme4和shiny程序包实现统计分析并建立交互式用户界面。该应用程序无需用户了解任何有关统计和编程的知识，也无需安装任何专业软件，便于无专业统计知识的用户使用。本文将重点介绍MetaDTA平台诊断试验准确性的量化、结果可视化、交互式功能等，结合实例向用户介绍该应用程序的具体操作方法，旨在帮助相关研究人员完成诊断准确性研究Meta分析、绘制汇总受试者工作特征（SROC）曲线、绘制纳入研究质量评价结果以及进行敏感性分析。

关键词: MetaDTA, 诊断试验准确性研究, Meta分析, 双变量模型

CLC Number:

R 44

YANG Shuihua,YAO Guiying,TIAN Chen, et al. MetaDTA: an Online Application for Diagnostic Test Accuracy Meta-analysis[J]. Chinese General Practice, 2025, 28(08): 1023-1032. DOI: 10.12114/j.issn.1007-9572.2024.0083.
杨水华,姚桂英,田晨等. MetaDTA：一款诊断试验准确性Meta分析在线应用程序[J]. 中国全科医学, 2025, 28(08): 1023-1032. DOI: 10.12114/j.issn.1007-9572.2024.0083.

Figures/Tables 15

References 15

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参数设置	选项
文件选择（File options）	是否将第一行作为列标题（First row as column headings）
示例数据格式（Select example dataset）	标准格式（Standard）-不涉及质量评价结果和协变量数据
	包含协变量数据格式（With Covariates）-仅涉及协变量数据
	包含质量评价结果格式（With Quality Assessment）-仅涉及质量评价结果数据
	包含质量评价结果和协变量数据格式（With Quality assessment and Covariates）-同时涉及质量评价结果和协变量数据

参数设置	选项
文件选择（File options）	是否将第一行作为列标题（First row as column headings）
示例数据格式（Select example dataset）	标准格式（Standard）-不涉及质量评价结果和协变量数据
	包含协变量数据格式（With Covariates）-仅涉及协变量数据
	包含质量评价结果格式（With Quality Assessment）-仅涉及质量评价结果数据
	包含质量评价结果和协变量数据格式（With Quality assessment and Covariates）-同时涉及质量评价结果和协变量数据

第一作者	发表时间（年）	TP	FN	FP	TN	rob_PS	rob_IT	rob_RS	rob_FT	ac_PS	ac_IT	ac_RS	阈值	国家	IQCODE
FLICKER	1997	188	28	35	48	2	2	2	3	1	3	1	3.6	澳大利亚	26
GARCIA	2002	83	7	4	19	2	1	1	1	1	1	1	3.6	西班牙	16
GONCALVES	2011	109	43	17	35	1	1	2	1	1	1	1	4.1	澳大利亚	16
HANCOCK	2009	73	12	36	23	1	2	1	1	1	3	1	3.6	英国	16
HARWOOD	1997	43	0	29	105	1	2	3	1	1	2	1	3.3	英国	16
JORM	1991	17	7	9	36	2	2	1	2	2	1	1	3.6	澳大利亚	26
KNAEFELC	2003	215	14	50	44	1	2	1	2	1	1	3	3.6	澳大利亚	16
MACKINNON	1998	52	6	17	31	2	2	1	3	3	3	1	3.6	瑞士	16
MULLIGAN	1996	33	0	25	18	2	2	3	3	3	3	3	3.3	瑞士	26
NARASIMHALU	2008	145	24	90	317	2	2	2	2	2	3	3	3.4	新加坡	16
SIKKES	2010	173	7	52	37	2	2	1	1	2	1	1	3.3	荷兰	16
SIRI	2006	94	6	12	88	2	2	1	2	3	2	3	3.3	泰国	32
TANG	2003	21	3	41	124	1	2	1	2	2	2	1	3.4	中国	26

第一作者	发表时间（年）	TP	FN	FP	TN	rob_PS	rob_IT	rob_RS	rob_FT	ac_PS	ac_IT	ac_RS	阈值	国家	IQCODE
FLICKER	1997	188	28	35	48	2	2	2	3	1	3	1	3.6	澳大利亚	26
GARCIA	2002	83	7	4	19	2	1	1	1	1	1	1	3.6	西班牙	16
GONCALVES	2011	109	43	17	35	1	1	2	1	1	1	1	4.1	澳大利亚	16
HANCOCK	2009	73	12	36	23	1	2	1	1	1	3	1	3.6	英国	16
HARWOOD	1997	43	0	29	105	1	2	3	1	1	2	1	3.3	英国	16
JORM	1991	17	7	9	36	2	2	1	2	2	1	1	3.6	澳大利亚	26
KNAEFELC	2003	215	14	50	44	1	2	1	2	1	1	3	3.6	澳大利亚	16
MACKINNON	1998	52	6	17	31	2	2	1	3	3	3	1	3.6	瑞士	16
MULLIGAN	1996	33	0	25	18	2	2	3	3	3	3	3	3.3	瑞士	26
NARASIMHALU	2008	145	24	90	317	2	2	2	2	2	3	3	3.4	新加坡	16
SIKKES	2010	173	7	52	37	2	2	1	1	2	1	1	3.3	荷兰	16
SIRI	2006	94	6	12	88	2	2	1	2	3	2	3	3.3	泰国	32
TANG	2003	21	3	41	124	1	2	1	2	2	2	1	3.4	中国	26

MetaDTA: an Online Application for Diagnostic Test Accuracy Meta-analysis

MetaDTA：一款诊断试验准确性Meta分析在线应用程序

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