
Chinese General Practice ›› 2024, Vol. 27 ›› Issue (35): 4403-4411.DOI: 10.12114/j.issn.1007-9572.2023.0441
• Original Research • Previous Articles Next Articles
Received:2023-10-03
Revised:2024-04-11
Published:2024-12-15
Online:2024-09-13
Contact:
GOU Lianping
通讯作者:
苟连平
作者简介:罗琴负责研究目标的提出,项目构思及设计,数据收集,论文撰写;苟连平整体负责文章的质量控制与审查,并对文章整体进行监督管理;罗琴、陈银负责绘制统计学图表;苏凤进行论文的修订。
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| 组别 | 例数 | 性别(男/女) | BMI ( | ASMI[M(P25,P75),kg/m2] | ASM[M(P25,P75),kg] | 骨骼肌量[M(P25,P75),kg] | 握力[M(P25,P75),kg] | 年龄[M(P25,P75),岁] | 体质量[M(P25,P75),kg] |
|---|---|---|---|---|---|---|---|---|---|
| 非肌少症组 | 155 | 99/56 | 23.4±2.8 | 7.36(6.63,7.99) | 19.8(16.0,22.1) | 26.1(21.6,29.3) | 20(16,24) | 71(67,77) | 59.8(55.6,65.9) |
| 肌少症组 | 58 | 37/21 | 20.2±2.5 | 6.45(5.59,6.82) | 16.6(12.9,18.2) | 21.8(18.6,23.6) | 24(19,28) | 74(69,78) | 51.4(46.0,57.2) |
| 检验统计量值 | <0.001a | -7.563b | -7.775 | -6.271 | -5.937 | -4.214 | -1.500 | -6.745 | |
| P值 | 0.992 | <0.001 | <0.001 | <0.001 | <0.001 | <0.001 | 0.134 | <0.001 | |
| 组别 | 身高[M(P25,P75),cm] | 上臂围[M(P25,P75),cm] | 小腿围[M(P25,P75),cm] | 上臂除脂周长[M(P25,P75),cm] | Ishii评分[M(P25,P75),分] | RBC[M(P25,P75),×1012/L] | PLT[M(P25,P75),×109/L] | 白蛋白[M(P25,P75),g/L] | |
| 非肌少症组 | 160(156,167) | 29.2(27.9,31.0) | 34.0(33.8,35.0) | 24.7(23.3,26.5) | 111.92(101.01,124.01) | 4.2(3.8,4.6) | 167(126,208) | 39.8(37.8,42.2) | |
| 肌少症组 | 160(155,165) | 26.9(24.8,28.0) | 33.0(32.0,33.5) | 22.5(20.9,23.4) | 131.56(123.20,142.80) | 4.3(3.8,4.6) | 186(148,241) | 39.7(38.5,41.2) | |
| 检验统计量值 | -2.094 | -2.649 | -7.110 | -7.223 | -7.038 | -0.091 | -2.470 | -0.164 | |
| P值 | 0.036 | 0.008 | <0.001 | <0.001 | <0.001 | 0.928 | 0.014 | 0.870 | |
| 组别 | Cr[M(P25,P75),µmol/L] | AST[M(P25,P75),U/L] | ALT[M(P25,P75),U/L] | TSH[M(P25,P75),U/L] | TC[M(P25,P75),mmol/L] | HDL-C( | TG[M(P25,P75),mmol/L] | D-二聚体[M(P25,P75),mg/L] | |
| 非肌少症组 | 78.6(65.9,101.2) | 24(20,32) | 22(16,33) | 2.20(1.30,3.10) | 3.85(3.17,4.64) | 1.06±0.28 | 1.17(0.84,1.75) | 0.82(0.65,1.08) | |
| 肌少症组 | 71.0(60.8,86.0) | 24(19,30) | 21(13,29) | 1.83(1.09,3.46) | 4.04(3.56,4.42) | 1.25±0.35 | 1.08(0.80,1.46) | 0.80(0.65,1.24) | |
| 检验统计量值 | -2.334 | -1.610 | -0.804 | -0.347 | -1.277 | 3.410b | -1.229 | -0.225 | |
| P值 | 0.020 | 0.872 | 0.421 | 0.728 | 0.202 | <0.001 | 0.219 | 0.822 |
Table 1 Comparison of general data between sarcopenia group and non-sarcopenia group
| 组别 | 例数 | 性别(男/女) | BMI ( | ASMI[M(P25,P75),kg/m2] | ASM[M(P25,P75),kg] | 骨骼肌量[M(P25,P75),kg] | 握力[M(P25,P75),kg] | 年龄[M(P25,P75),岁] | 体质量[M(P25,P75),kg] |
|---|---|---|---|---|---|---|---|---|---|
| 非肌少症组 | 155 | 99/56 | 23.4±2.8 | 7.36(6.63,7.99) | 19.8(16.0,22.1) | 26.1(21.6,29.3) | 20(16,24) | 71(67,77) | 59.8(55.6,65.9) |
| 肌少症组 | 58 | 37/21 | 20.2±2.5 | 6.45(5.59,6.82) | 16.6(12.9,18.2) | 21.8(18.6,23.6) | 24(19,28) | 74(69,78) | 51.4(46.0,57.2) |
| 检验统计量值 | <0.001a | -7.563b | -7.775 | -6.271 | -5.937 | -4.214 | -1.500 | -6.745 | |
| P值 | 0.992 | <0.001 | <0.001 | <0.001 | <0.001 | <0.001 | 0.134 | <0.001 | |
| 组别 | 身高[M(P25,P75),cm] | 上臂围[M(P25,P75),cm] | 小腿围[M(P25,P75),cm] | 上臂除脂周长[M(P25,P75),cm] | Ishii评分[M(P25,P75),分] | RBC[M(P25,P75),×1012/L] | PLT[M(P25,P75),×109/L] | 白蛋白[M(P25,P75),g/L] | |
| 非肌少症组 | 160(156,167) | 29.2(27.9,31.0) | 34.0(33.8,35.0) | 24.7(23.3,26.5) | 111.92(101.01,124.01) | 4.2(3.8,4.6) | 167(126,208) | 39.8(37.8,42.2) | |
| 肌少症组 | 160(155,165) | 26.9(24.8,28.0) | 33.0(32.0,33.5) | 22.5(20.9,23.4) | 131.56(123.20,142.80) | 4.3(3.8,4.6) | 186(148,241) | 39.7(38.5,41.2) | |
| 检验统计量值 | -2.094 | -2.649 | -7.110 | -7.223 | -7.038 | -0.091 | -2.470 | -0.164 | |
| P值 | 0.036 | 0.008 | <0.001 | <0.001 | <0.001 | 0.928 | 0.014 | 0.870 | |
| 组别 | Cr[M(P25,P75),µmol/L] | AST[M(P25,P75),U/L] | ALT[M(P25,P75),U/L] | TSH[M(P25,P75),U/L] | TC[M(P25,P75),mmol/L] | HDL-C( | TG[M(P25,P75),mmol/L] | D-二聚体[M(P25,P75),mg/L] | |
| 非肌少症组 | 78.6(65.9,101.2) | 24(20,32) | 22(16,33) | 2.20(1.30,3.10) | 3.85(3.17,4.64) | 1.06±0.28 | 1.17(0.84,1.75) | 0.82(0.65,1.08) | |
| 肌少症组 | 71.0(60.8,86.0) | 24(19,30) | 21(13,29) | 1.83(1.09,3.46) | 4.04(3.56,4.42) | 1.25±0.35 | 1.08(0.80,1.46) | 0.80(0.65,1.24) | |
| 检验统计量值 | -2.334 | -1.610 | -0.804 | -0.347 | -1.277 | 3.410b | -1.229 | -0.225 | |
| P值 | 0.020 | 0.872 | 0.421 | 0.728 | 0.202 | <0.001 | 0.219 | 0.822 |
| 性别 | 诊断指标 | AUC | 95%CI | P值 | 最佳截断值 | 约登指数 | 灵敏度(%) | 特异度(%) |
|---|---|---|---|---|---|---|---|---|
| 男 | Ishii评分 | 0.818 | 0.749~0.888 | <0.001 | 114.07分 | 0.545 | 91.9 | 62.6 |
| 上臂围 | 0.841 | 0.768~0.915 | <0.001 | 28.0 cm | 0.562 | 70.3 | 85.9 | |
| 小腿围 | 0.854 | 0.788~0.920 | <0.001 | 34.3 cm | 0.511 | 86.5 | 64.6 | |
| 女 | Ishii评分 | 0.812 | 0.719~0.904 | <0.001 | 120.08分 | 0.643 | 100.0 | 64.3 |
| 上臂围 | 0.797 | 0.692~0.901 | <0.001 | 27.5 cm | 0.506 | 81.0 | 69.6 | |
| 小腿围 | 0.835 | 0.746~0.924 | <0.001 | 33.8 cm | 0.500 | 100.0 | 50.0 |
Table 2 Evaluative value of Ishii score,calf circumference and upper arm circumference in the diagnosis of sarcopenia
| 性别 | 诊断指标 | AUC | 95%CI | P值 | 最佳截断值 | 约登指数 | 灵敏度(%) | 特异度(%) |
|---|---|---|---|---|---|---|---|---|
| 男 | Ishii评分 | 0.818 | 0.749~0.888 | <0.001 | 114.07分 | 0.545 | 91.9 | 62.6 |
| 上臂围 | 0.841 | 0.768~0.915 | <0.001 | 28.0 cm | 0.562 | 70.3 | 85.9 | |
| 小腿围 | 0.854 | 0.788~0.920 | <0.001 | 34.3 cm | 0.511 | 86.5 | 64.6 | |
| 女 | Ishii评分 | 0.812 | 0.719~0.904 | <0.001 | 120.08分 | 0.643 | 100.0 | 64.3 |
| 上臂围 | 0.797 | 0.692~0.901 | <0.001 | 27.5 cm | 0.506 | 81.0 | 69.6 | |
| 小腿围 | 0.835 | 0.746~0.924 | <0.001 | 33.8 cm | 0.500 | 100.0 | 50.0 |
| 筛查工具 | AUC | 95%CI | P值 | 灵敏度(%) | 特异度(%) | 阳性预测值(%) | 阴性预测值(%) |
|---|---|---|---|---|---|---|---|
| Ishii评分 | 0.814 | 0.758~0.869 | <0.001 | 29.3 | 90.3 | 53.1 | 77.3 |
| 上臂围 | 0.814 | 0.752~0.875 | <0.001 | 36.2 | 92.9 | 65.6 | 82.3 |
| 小腿围 | 0.813 | 0.752~0.874 | <0.001 | 41.4 | 92.9 | 68.6 | 78.6 |
Table 3 Comparison of the accuracy of Ishii score,calf circumference and upper arm circumference in the diagnosis of sarcopenia
| 筛查工具 | AUC | 95%CI | P值 | 灵敏度(%) | 特异度(%) | 阳性预测值(%) | 阴性预测值(%) |
|---|---|---|---|---|---|---|---|
| Ishii评分 | 0.814 | 0.758~0.869 | <0.001 | 29.3 | 90.3 | 53.1 | 77.3 |
| 上臂围 | 0.814 | 0.752~0.875 | <0.001 | 36.2 | 92.9 | 65.6 | 82.3 |
| 小腿围 | 0.813 | 0.752~0.874 | <0.001 | 41.4 | 92.9 | 68.6 | 78.6 |
| 性别 | 筛查工具 | 2023肌少症共识 | 合计 | Kappa值 | P值 | ||
|---|---|---|---|---|---|---|---|
| 是 | 否 | ||||||
| 男性 | 小腿围 | (+) | 32 | 35 | 67 | 0.408 | <0.001 |
| (-) | 5 | 64 | 69 | ||||
| 上臂围 | (+) | 26 | 14 | 40 | 0.547 | <0.001 | |
| (-) | 11 | 85 | 96 | ||||
| Ishii评分 | (+) | 34 | 37 | 71 | 0.423 | <0.001 | |
| (-) | 3 | 62 | 65 | ||||
| 女性 | 小腿围 | (+) | 21 | 28 | 49 | 0.353 | <0.001 |
| (-) | 0 | 28 | 28 | ||||
| 上臂围 | (+) | 17 | 17 | 34 | 0.424 | <0.001 | |
| (-) | 4 | 39 | 43 | ||||
| Ishii评分 | (+) | 21 | 20 | 41 | 0.495 | <0.001 | |
| (-) | 0 | 36 | 36 | ||||
Table 4 Results of the consistency test of Ishii score,calf circumference and upper arm circumference with the diagnostic criteria of Chinese expert consensus (2023) criteria for the prevention and treatment of sarcopenia in the elderly
| 性别 | 筛查工具 | 2023肌少症共识 | 合计 | Kappa值 | P值 | ||
|---|---|---|---|---|---|---|---|
| 是 | 否 | ||||||
| 男性 | 小腿围 | (+) | 32 | 35 | 67 | 0.408 | <0.001 |
| (-) | 5 | 64 | 69 | ||||
| 上臂围 | (+) | 26 | 14 | 40 | 0.547 | <0.001 | |
| (-) | 11 | 85 | 96 | ||||
| Ishii评分 | (+) | 34 | 37 | 71 | 0.423 | <0.001 | |
| (-) | 3 | 62 | 65 | ||||
| 女性 | 小腿围 | (+) | 21 | 28 | 49 | 0.353 | <0.001 |
| (-) | 0 | 28 | 28 | ||||
| 上臂围 | (+) | 17 | 17 | 34 | 0.424 | <0.001 | |
| (-) | 4 | 39 | 43 | ||||
| Ishii评分 | (+) | 21 | 20 | 41 | 0.495 | <0.001 | |
| (-) | 0 | 36 | 36 | ||||
| 研究 | 性别 | 2023肌少症共识 | 合计 | Kappa值 | P值 | ||
|---|---|---|---|---|---|---|---|
| 是 | 否 | ||||||
| Ishii研究 | 男性 | (+) | 37 | 64 | 101 | 0.229 | <0.001 |
| (-) | 0 | 35 | 35 | ||||
| 女性 | (+) | 21 | 21 | 42 | 0.476 | <0.001 | |
| (-) | 0 | 35 | 35 | ||||
| 本研究 | 男性 | (+) | 34 | 37 | 71 | 0.423 | <0.001 |
| (-) | 3 | 62 | 65 | ||||
| 女性 | (+) | 21 | 20 | 41 | 0.495 | <0.001 | |
| (-) | 0 | 36 | 36 | ||||
Table 5 Comparison of the effect of two Ishii cut-off values in determining sarcopenia
| 研究 | 性别 | 2023肌少症共识 | 合计 | Kappa值 | P值 | ||
|---|---|---|---|---|---|---|---|
| 是 | 否 | ||||||
| Ishii研究 | 男性 | (+) | 37 | 64 | 101 | 0.229 | <0.001 |
| (-) | 0 | 35 | 35 | ||||
| 女性 | (+) | 21 | 21 | 42 | 0.476 | <0.001 | |
| (-) | 0 | 35 | 35 | ||||
| 本研究 | 男性 | (+) | 34 | 37 | 71 | 0.423 | <0.001 |
| (-) | 3 | 62 | 65 | ||||
| 女性 | (+) | 21 | 20 | 41 | 0.495 | <0.001 | |
| (-) | 0 | 36 | 36 | ||||
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