Recent Developments in Long-term Effects of Mild Hypothyroidism During Pregnancy on Offspring Intelligence

doi:10.12114/j.issn.1007-9572.2020.00.163

Abstract

Abstract: There are substantial available data showing impaired child intelligence resulting from overt maternal hypothyroidism during pregnancy.This review addresses the effect of mild maternal hypothyroidism on long-term development of intelligence of children.It is concluded that mild maternal hypothyroidism may affect children's mental development.However，the mechanisms that cause this change and how to eliminate these risk factors remain unclear and a large number of clinical and basic experiments are still required to provide evidence for treatment.

Key words: Pregnancy complications, Hypothyroidism, Duration of pregnancy, Hypothyroxemia, Offspring intelligence

摘要： 妊娠期母体患有明显的甲状腺功能减退时会对子代的远期智力造成不良影响。本文主要对妊娠期母体轻度甲状腺功能减退对子代远期智力的影响进行综述，得出母体轻度甲状腺功能减退可能影响子代的智力发育，但是对于引起这种变化的具体机制以及如何消除这类危险因素，目前还没有确切的方案，仍需大量临床试验和基础实验提供治疗依据。

关键词: 妊娠并发症, 甲状腺功能减退症, 妊娠期, 低甲状腺素血症, 子代智力

GAO Xue,LONG Yan,LIN Li. Recent Developments in Long-term Effects of Mild Hypothyroidism During Pregnancy on Offspring Intelligence　[J]. Chinese General Practice, 2020, 23(15): 1838-1842. DOI: 10.12114/j.issn.1007-9572.2020.00.163.
高雪,龙燕,蔺莉. 妊娠期轻度甲状腺功能减退对子代远期智力的影响研究进展[J]. 中国全科医学, 2020, 23(15): 1838-1842. DOI: 10.12114/j.issn.1007-9572.2020.00.163.

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