Abstract: Tumor-induced osteomalacia（TIO） is a rare paraneoplastic syndrome in the clinic setting.TIO is caused by excessive phosphorus excretion induced by the tumor，and is thus categorized as an acquired hypophosphatemic osteomalacia.TIO has an occult onset and is associated with a high rate of misdiagnosis，although TIO has some typical clinical features，such as amyosthenia，progressive ostealgia，and loss of height.Practitioners should have increased awareness of TIO.Early diagnosis，correctly positioning of the tumor，and surgical resection can achieve good outcomes.For those patients suspected to have TIO，a thorough physical examination combined with laboratory testing and imaging are sufficient for the detection and positioning of the tumor.We report herein a patient who was diagnosed with TIO and successfully treated.The relevant literature is reviewed to improve the knowledge of the disease and provide reference for clinical work.

Key words: Osteomalacia, Lipoma, Hypophosphatemia

摘要： 肿瘤性低磷骨软化症（TIO）是临床上一种罕见的伴瘤综合征，由肿瘤导致肾脏排磷增加，造成的获得性低血磷骨软化症。TIO起病隐匿，临床误诊率较高，但仍具有典型的临床特点，如肌无力、进行性骨痛、身高变矮等。临床中应提高对该病的认识，早期诊断，明确肿瘤位置，手术切除一般可达到较好的治疗效果。对于疑似TIO患者，仔细的体格检查，并结合实验室检查、影像学检查等手段对肿瘤的发现和定位具有重要意义。本文回顾性报道了被诊断为TIO且得到成功诊治的患者1例，并对相关文献进行了复习，以提高临床医生对本病的认识，为临床工作提供借鉴。

关键词: 骨软化症, 脂肪瘤, 低磷血症