Abstract: Objective　To explore the clinical effectiveness of Boguzhuyu Granules in the early treatment of simple thoracolumbar compression fractures.Methods　We enrolled 180 cases of thoracolumbar compression fractures from Department of Orthopedics，the First Affiliated Hospital of Guangxi University of Chinese Medicine from June 2013 to April 2016，and divided them into the observation group and control group by block randomization method.Based on the treatment with a soft and thin protective padding covering the fracture site and back extension exercise，the observation group orally took Boguzhuyu Granules after mixing it with lukewarm boiled water，while the control group orally took Mannitol Injection.The outcome was evaluated by pain status assessed by Visual Analogue Scale（VAS），defecation after medication as well as clinical response.Results　There was no significant difference between two groups with respect to VAS score before the treatment（P>0.05）．However，VAS score decreased significantly in the observation group after treatment（P<0.05）．The defecation status after medication was similar in both groups（P>0.05）．The observation group demonstrated much better clinical response（P<0.05）．Conclusion　Boguzhuyu Granules developed by the Zhuang people is simple，convenient and safe for clinical treatment of thoracolumbar compression fractures，which can effectively reduce the post-fracture pain and improve the quality of life.

Key words: Fractures, compression；Lumbar vertebrae；Thoracic vertebrae；Treatment outcome

摘要： 目的　探讨驳骨逐瘀颗粒治疗单纯胸腰椎压缩性骨折的临床疗效。方法　选取2013年6月—2016年4月于广西中医药大学第一附属医院骨科治疗的单纯胸腰椎压缩性骨折患者180例，采用随机数字表法将患者分为观察组和对照组，各90例。两组均接受腰部垫枕法、腰背肌后伸功能锻炼治疗，在此基础上观察组给予驳骨逐瘀颗粒治疗，对照组口服甘露醇治疗。治疗前后采用视觉模拟评分法（VAS）评价两组患者疼痛情况，观察用药后排便情况及临床疗效。结果　治疗前两组患者VAS评分比较，差异无统计学意义（P>0.05）；治疗后观察组VAS评分低于对照组（P<0.05）。两组首次排便情况比较，差异无统计学意义（P>0.05）。观察组患者临床疗效优于对照组（P<0.05）。结论　驳骨逐瘀颗粒能有效减轻单纯胸腰椎压缩性骨折后疼痛，提高患者生活质量，且临床运用安全。其既具有壮族医药民族特色，又符合简、便、廉原则。

关键词: 骨折, 压缩性, 腰椎, 胸椎, 治疗结果