Myelosuppression is one of the most common adverse effects of chemotherapy for lung cancer, in response to chemotherapy-related myelosuppression, modern medicine mostly adopts symptomatic treatment, but there are many limitations.

To investigate the effects of press-needle therapy on pevention of myelosuppression after chemotherapy of lung cancer patients based on the midnight-noon ebb-flow point selection theory.

A total of 142 non-small cell lung cancer (NSCLC) patients during first chemotherapy hospitalized in the respiratory department of Northern Jiangsu People's Hospital from July 2020 to June 2022 were selected and randomly divided into the control group (n=47) , press-needle group (n=48) and timing group (n=47) according to a prior computer-generated random number table and the developed allocation scheme. The control group received routine care measures, the press-needle group received press-needle therapy at acupoints such as Geshu acupoint, Pishu acupoint and Weishu acupoint on the basis of routine care measures, the timing group received press-needle therapy between 7 a.m. and 11 a.m on the day using midnight-noon ebb-flow method on the basis of routine care measures. The changes of blood routine indicators reflecting myelosuppression and the comfort scores before chemotherapy and 3rd, 7th, 14th, 21st days of chemotherapy were observed in the three groups.

The white blood cell count and neutrophil count in the press needle group and timing group were higher than the control group, and the white blood cell count and neutrophil count in the timing group were higher than the press needle group on the 7th and 14th days of chemotherapy (P< 0.05) ; the platelet count in the press needle group and timing group were higher than the control group on the 7th and 14th days of chemotherapy (P< 0.05) . The comfort scores in the press needle group and timing group were higher than the control group on the 7th and 14th days of chemotherapy (P< 0.05) , the comfort scores in the timing group were higher than the press needle group on the 14th day of chemotherapy (P< 0.05) .

The timing press-needle therapy based on the midnight-noon ebb-flow point selection theory can effectively prevent myelosuppression, improve blood routine indicators including white blood cell count, neutrophil count and platelet count, and promot comfort in NSCLC patients after chemotherapy.

骨髓抑制是肺癌化疗常见的不良反应之一，针对化疗相关性骨髓抑制，现代医学多采用对症治疗，但存在一定局限性。

探讨"子午流注"理论指导下择时揿针疗法预防肺癌化疗后骨髓抑制的效果。

选择2020年7月—2022年6月在江苏省苏北人民医院呼吸科住院的142例首次行化疗的非小细胞肺癌（NSCLC）患者，按事先电脑生成的随机数字表和制订的分配方案，根据入院时间将研究对象随机分为对照组（47例）、揿针组（48例）及择时组（47例）。对照组给予肺癌化疗常规护理措施，揿针组在对照组措施基础上加用膈俞穴、脾俞穴、胃俞穴等穴位揿针疗法，择时组在对照组遵循子午流注纳子法于当日辰时（7:00—9:00）至巳时（9:00—11:00）实施择时揿针疗法。检测分析三组化疗前1 d及化疗第3、7、14、21天反映骨髓抑制情况的血常规指标及舒适度评分的变化情况。

白细胞计数、中性粒细胞计数：揿针组和择时组化疗第7、14天均高于对照组（P<0.05），择时组均高于揿针组（P<0.05）；血小板计数：化疗第7、14天揿针组和择时组均高于对照组（P<0.05）。舒适度评分：化疗第7、14天揿针组和择时组均高于对照组（P<0.05），化疗第14天择时组高于揿针组（P<0.05）。

子午流注择时揿针疗法能有效预防NSCLC患者化疗后骨髓抑制，提高白细胞计数、中性粒细胞计数和血小板计数等部分血常规指标，提升患者的舒适度。