Chinese General Practice ›› 2023, Vol. 26 ›› Issue (10): 1234-1240.DOI: 10.12114/j.issn.1007-9572.2022.0870
• Original Research·Focus on Cognitive Impairment • Previous Articles Next Articles
Received:
2022-12-16
Revised:
2023-02-06
Published:
2023-04-05
Online:
2023-02-09
Contact:
ZHANG Zhongde
About author:
通讯作者:
张忠德
作者简介:
基金资助:
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URL: https://www.chinagp.net/EN/10.12114/j.issn.1007-9572.2022.0870
组别 | 例数 | 性别〔n(%)〕 | 年龄( | 基础疾病〔n(%)〕 | 入院新冠感染分型〔n(%)〕 | 出院至本次调查的间隔时间( | ||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|
男 | 女 | 呼吸系统疾病 | 高血压 | 糖尿病 | 冠心病 | 脑血管病 | 非重症 | 重症 | ||||
存在极早期认知功能障碍 | 170 | 44(25.9) | 126(74.1) | 57.5±10.2 | 5(2.9) | 38(22.3) | 19(11.2) | 12(7.0) | 5(2.9) | 134(78.8) | 36(21.2) | 193.1±17.1 |
不存在极早期认知功能障碍 | 141 | 71(50.4) | 70(49.6) | 54.5±12.4 | 7(5.0) | 33(23.4) | 14(9.9) | 5(3.5) | 4(2.8) | 115(81.6) | 26(18.4) | 194.4±17.2 |
χ2(t)值 | 19.807 | 5.368a | 0.851 | 0.048 | 0.126 | 1.840 | <0.001 | 0.362 | 0.451a | |||
P值 | <0.01 | 0.02 | 0.36 | 0.83 | 0.72 | 0.18 | 0.99 | 0.55 | 0.50 |
Table 1 Comparison of general information of COVID-19 convalescents with and without very early cognitive impairment
组别 | 例数 | 性别〔n(%)〕 | 年龄( | 基础疾病〔n(%)〕 | 入院新冠感染分型〔n(%)〕 | 出院至本次调查的间隔时间( | ||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|
男 | 女 | 呼吸系统疾病 | 高血压 | 糖尿病 | 冠心病 | 脑血管病 | 非重症 | 重症 | ||||
存在极早期认知功能障碍 | 170 | 44(25.9) | 126(74.1) | 57.5±10.2 | 5(2.9) | 38(22.3) | 19(11.2) | 12(7.0) | 5(2.9) | 134(78.8) | 36(21.2) | 193.1±17.1 |
不存在极早期认知功能障碍 | 141 | 71(50.4) | 70(49.6) | 54.5±12.4 | 7(5.0) | 33(23.4) | 14(9.9) | 5(3.5) | 4(2.8) | 115(81.6) | 26(18.4) | 194.4±17.2 |
χ2(t)值 | 19.807 | 5.368a | 0.851 | 0.048 | 0.126 | 1.840 | <0.001 | 0.362 | 0.451a | |||
P值 | <0.01 | 0.02 | 0.36 | 0.83 | 0.72 | 0.18 | 0.99 | 0.55 | 0.50 |
组别 | 例数 | 失眠 | 疲倦乏力 | 咳嗽 | 胸闷 | 胸痛 | 气短 | 心慌心悸 | 食欲减退 |
---|---|---|---|---|---|---|---|---|---|
存在极早期认知功能障碍 | 170 | 64(37.6) | 107(62.9) | 21(12.3) | 72(42.3) | 19(11.2) | 68(40.0) | 5(2.9) | 18(10.6) |
不存在极早期认知功能障碍 | 141 | 30(21.3) | 45(31.9) | 13(9.2) | 30(21.3) | 9(6.4) | 29(20.6) | 3(2.1) | 3(2.1) |
χ2值 | 9.794 | 29.693 | 0.777 | 15.534 | 2.162 | 13.561 | 0.008 | 8.762 | |
P值 | <0.01 | <0.01 | 0.38 | <0.01 | 0.14 | <0.01 | 0.93 | 0.03 |
Table 2 Comparison of post-discharge residual symptoms in COVID-19 convalescents with and without very early cognitive impairment
组别 | 例数 | 失眠 | 疲倦乏力 | 咳嗽 | 胸闷 | 胸痛 | 气短 | 心慌心悸 | 食欲减退 |
---|---|---|---|---|---|---|---|---|---|
存在极早期认知功能障碍 | 170 | 64(37.6) | 107(62.9) | 21(12.3) | 72(42.3) | 19(11.2) | 68(40.0) | 5(2.9) | 18(10.6) |
不存在极早期认知功能障碍 | 141 | 30(21.3) | 45(31.9) | 13(9.2) | 30(21.3) | 9(6.4) | 29(20.6) | 3(2.1) | 3(2.1) |
χ2值 | 9.794 | 29.693 | 0.777 | 15.534 | 2.162 | 13.561 | 0.008 | 8.762 | |
P值 | <0.01 | <0.01 | 0.38 | <0.01 | 0.14 | <0.01 | 0.93 | 0.03 |
组别 | 例数 | 广泛性焦虑症〔n(%)〕 | PTSD阳性〔n(%)〕 | SF-36(分) | ||||
---|---|---|---|---|---|---|---|---|
生理功能( | 生理职能〔M(P25,P75)〕 | 躯体疼痛( | 一般健康状况( | 精力( | ||||
存在极早期认知功能障碍 | 170 | 24(14.1) | 23(13.5) | 83.7±13.1 | 0(0,100.0) | 83.5±25.2 | 51.0±19.6 | 56.9±20.1 |
不存在极早期认知功能障碍 | 141 | 3(2.1) | 2(1.4) | 92.4±10.7 | 100.0(0,100.0) | 90.9±18.9 | 70.8±18.6 | 72.8±18.9 |
检验统计量值 | 12.505a | 13.698a | 39.720b | 30.831c | 8.280b | 82.856b | 50.739b | |
P值 | <0.01 | <0.01 | <0.01 | <0.01 | <0.01 | <0.01 | <0.001 | |
组别 | SF-36(分) | PCS | MCS | |||||
精神健康( | 社会功能〔M(P25,P75)〕 | 情感职能〔M(P25,P75)〕 | 得分( | PCS<50分〔n(%)〕 | 得分( | MCS<50分〔n(%)〕 | ||
存在极早期认知功能障碍 | 52.4±17.4 | 50.0(25.0,100.0) | 0(0,100.0) | 48.7±7.6 | 94(55.3) | 35.8±10.9 | 148(87.0) | |
不存在极早期认知功能障碍 | 63.0±15.3 | 100.0(50.0,100.0) | 100.0(66.7,100.0) | 53.9±7.2 | 38(26.9) | 45.0±8.9 | 96(68.1) | |
检验统计量值 | 32.308b | 29.497c | 37.507c | 37.432b | 24.199a | 65.299b | 15.313a | |
P值 | <0.001 | <0.01 | <0.01 | <0.01 | <0.01 | <0.01 | <0.01 |
Table 3 Comparison of anxiety,post-traumatic stress disorder,and SF-36 scores among COVID-19 convalescents with and without very early cognitive impairment
组别 | 例数 | 广泛性焦虑症〔n(%)〕 | PTSD阳性〔n(%)〕 | SF-36(分) | ||||
---|---|---|---|---|---|---|---|---|
生理功能( | 生理职能〔M(P25,P75)〕 | 躯体疼痛( | 一般健康状况( | 精力( | ||||
存在极早期认知功能障碍 | 170 | 24(14.1) | 23(13.5) | 83.7±13.1 | 0(0,100.0) | 83.5±25.2 | 51.0±19.6 | 56.9±20.1 |
不存在极早期认知功能障碍 | 141 | 3(2.1) | 2(1.4) | 92.4±10.7 | 100.0(0,100.0) | 90.9±18.9 | 70.8±18.6 | 72.8±18.9 |
检验统计量值 | 12.505a | 13.698a | 39.720b | 30.831c | 8.280b | 82.856b | 50.739b | |
P值 | <0.01 | <0.01 | <0.01 | <0.01 | <0.01 | <0.01 | <0.001 | |
组别 | SF-36(分) | PCS | MCS | |||||
精神健康( | 社会功能〔M(P25,P75)〕 | 情感职能〔M(P25,P75)〕 | 得分( | PCS<50分〔n(%)〕 | 得分( | MCS<50分〔n(%)〕 | ||
存在极早期认知功能障碍 | 52.4±17.4 | 50.0(25.0,100.0) | 0(0,100.0) | 48.7±7.6 | 94(55.3) | 35.8±10.9 | 148(87.0) | |
不存在极早期认知功能障碍 | 63.0±15.3 | 100.0(50.0,100.0) | 100.0(66.7,100.0) | 53.9±7.2 | 38(26.9) | 45.0±8.9 | 96(68.1) | |
检验统计量值 | 32.308b | 29.497c | 37.507c | 37.432b | 24.199a | 65.299b | 15.313a | |
P值 | <0.001 | <0.01 | <0.01 | <0.01 | <0.01 | <0.01 | <0.01 |
自变量 | b | SE | Wald χ2值 | OR(95%CI) | P值 | |
---|---|---|---|---|---|---|
性别(以男为参照) | ||||||
女 | 0.978 | 0.283 | 11.971 | 2.658(1.528,4.625) | 0.01 | |
年龄(岁,以实际值纳入) | 1.318 | 0.632 | 4.352 | 3.736(1.083,12.890) | 0.04 | |
出院后遗留症状(以无相应症状为参照) | ||||||
失眠 | 0.346 | 0.295 | 1.373 | 1.413(0.792,2.520) | 0.24 | |
疲倦乏力 | 0.540 | 0.288 | 3.514 | 1.716(0.976,3.020) | 0.06 | |
胸闷 | 0.281 | 0.347 | 0.656 | 1.324(0.671,2.612) | 0.42 | |
气短 | 0.170 | 0.372 | 0.208 | 1.185(0.572,2.456) | 0.65 | |
食欲减退 | 1.141 | 0.704 | 2.629 | 3.129(0.788,12.424) | 0.11 | |
广泛性焦虑症(以无为参照) | ||||||
有 | 1.625 | 0.724 | 5.037 | 5.081(1.229,21.008) | 0.03 | |
PTSD阳性(以否为参照) | ||||||
是 | 0.924 | 0.842 | 1.206 | 2.520(0.484,13.125) | 0.27 | |
PCS(分,以≥50为参照) | ||||||
<50 | 0.459 | 0.298 | 2.362 | 1.616(0.839,3.113) | 0.12 | |
MCS(分,以≥50为参照) | ||||||
<50 | 0.408 | 0.334 | 2.061 | 1.582(0.881,2.839) | 0.15 |
Table 4 A multivariate Logistic regression analysis of factors influencing very early cognitive impairment in COVID-19 convalescents
自变量 | b | SE | Wald χ2值 | OR(95%CI) | P值 | |
---|---|---|---|---|---|---|
性别(以男为参照) | ||||||
女 | 0.978 | 0.283 | 11.971 | 2.658(1.528,4.625) | 0.01 | |
年龄(岁,以实际值纳入) | 1.318 | 0.632 | 4.352 | 3.736(1.083,12.890) | 0.04 | |
出院后遗留症状(以无相应症状为参照) | ||||||
失眠 | 0.346 | 0.295 | 1.373 | 1.413(0.792,2.520) | 0.24 | |
疲倦乏力 | 0.540 | 0.288 | 3.514 | 1.716(0.976,3.020) | 0.06 | |
胸闷 | 0.281 | 0.347 | 0.656 | 1.324(0.671,2.612) | 0.42 | |
气短 | 0.170 | 0.372 | 0.208 | 1.185(0.572,2.456) | 0.65 | |
食欲减退 | 1.141 | 0.704 | 2.629 | 3.129(0.788,12.424) | 0.11 | |
广泛性焦虑症(以无为参照) | ||||||
有 | 1.625 | 0.724 | 5.037 | 5.081(1.229,21.008) | 0.03 | |
PTSD阳性(以否为参照) | ||||||
是 | 0.924 | 0.842 | 1.206 | 2.520(0.484,13.125) | 0.27 | |
PCS(分,以≥50为参照) | ||||||
<50 | 0.459 | 0.298 | 2.362 | 1.616(0.839,3.113) | 0.12 | |
MCS(分,以≥50为参照) | ||||||
<50 | 0.408 | 0.334 | 2.061 | 1.582(0.881,2.839) | 0.15 |
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