Chinese General Practice ›› 2022, Vol. 25 ›› Issue (06): 693-698.DOI: 10.12114/j.issn.1007-9572.2021.02.126
Special Issue: 内分泌代谢性疾病最新文章合集
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*Corresponding author:WAN Qin,Chief physician,Professor,Master supervisor;E-mail:wanqin3@163.com
Received:
2021-08-16
Revised:
2021-12-06
Published:
2022-02-20
Online:
2021-12-21
通讯作者:
万沁
基金资助:
CLC Number:
LI Hang, LIU Yiying, LIU Yao, LIN Jie, WAN Qin. Predictive Value of Hemoglobin Glycation Index for Hyperuricemia in Type 2 Diabetes[J]. Chinese General Practice, 2022, 25(06): 693-698.
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URL: https://www.chinagp.net/EN/10.12114/j.issn.1007-9572.2021.02.126
组别 | 例数 | 性别(男/女) | 年龄〔M(P25,P75),岁〕 | T2DM病程〔M(P25,P75),月〕 | 吸烟史〔n(%)〕 | 饮酒史〔n(%)〕 | 高血压病史〔n(%)〕 | 身高〔M(P25,P75),cm〕 |
---|---|---|---|---|---|---|---|---|
低HGI组 | 398 | 197/201 | 60.0(52.0,66.0) | 80.0(33.0,137.0) | 44(11.06) | 119(29.90) | 163(40.95) | 160.0(153.0,167.0) |
中HGI组 | 398 | 207/191 | 57.0(50.0,65.0) | 79.0(11.0,153.5) | 32(8.04) | 135(33.92) | 137(34.42) | 161.0(155.0,167.0) |
高HGI组 | 398 | 188/210 | 59.0(51.8,67.0) | 88.5(45.0,168.0) | 39(9.80) | 107(26.88) | 154(38.69) | 160.0(154.0,166.0) |
Z(χ2)值 | 1.816a | 8.880 | 3.975 | 2.098a | 4.701a | 3.717a | 1.737 | |
P值 | 0.403 | 0.012 | 0.137 | 0.350 | 0.095 | 0.156 | 0.420 |
Table 1 Comparison of clinical data of patients with T2DM in hemoglobin glycation index tertile groups
组别 | 例数 | 性别(男/女) | 年龄〔M(P25,P75),岁〕 | T2DM病程〔M(P25,P75),月〕 | 吸烟史〔n(%)〕 | 饮酒史〔n(%)〕 | 高血压病史〔n(%)〕 | 身高〔M(P25,P75),cm〕 |
---|---|---|---|---|---|---|---|---|
低HGI组 | 398 | 197/201 | 60.0(52.0,66.0) | 80.0(33.0,137.0) | 44(11.06) | 119(29.90) | 163(40.95) | 160.0(153.0,167.0) |
中HGI组 | 398 | 207/191 | 57.0(50.0,65.0) | 79.0(11.0,153.5) | 32(8.04) | 135(33.92) | 137(34.42) | 161.0(155.0,167.0) |
高HGI组 | 398 | 188/210 | 59.0(51.8,67.0) | 88.5(45.0,168.0) | 39(9.80) | 107(26.88) | 154(38.69) | 160.0(154.0,166.0) |
Z(χ2)值 | 1.816a | 8.880 | 3.975 | 2.098a | 4.701a | 3.717a | 1.737 | |
P值 | 0.403 | 0.012 | 0.137 | 0.350 | 0.095 | 0.156 | 0.420 |
项目 | β | SE | OR(95%CI) | Wald χ2值 | P值 |
---|---|---|---|---|---|
性别 | 0.102 | 0.133 | 1.107(0.853,1.438) | 0.583 | 0.445 |
年龄 | 0.035 | 0.007 | 1.036(1.023,1.050) | 28.388 | 0.001 |
T2DM病程 | 0.001 | 0.001 | 1.001(0.999,1.002) | 0.947 | 0.331 |
吸烟史 | -0.218 | 0.237 | 0.804(0.506,1.279) | 0.848 | 0.357 |
饮酒史 | 0.056 | 0.144 | 1.058(0.797,1.403) | 0.152 | 0.696 |
高血压病史 | 0.628 | 0.135 | 1.874(1.438,2.442) | 21.649 | 0.001 |
身高 | 0.018 | 0.008 | 1.018(1.003,1.034) | 5.230 | 0.022 |
体质量 | 0.037 | 0.006 | 1.038(1.027,1.050) | 42.791 | 0.001 |
腰围 | 0.050 | 0.007 | 1.051(1.037,1.065) | 52.841 | 0.001 |
臀围 | 0.047 | 0.009 | 1.048(1.029,1.067) | 26.201 | 0.001 |
BMI | 0.133 | 0.020 | 1.143(1.100,1.187) | 46.488 | 0.001 |
DBP | 0.026 | 0.006 | 1.027(1.014,1.039) | 17.220 | 0.001 |
SBP | 0.013 | 0.003 | 1.013(1.007,1.020) | 15.991 | 0.001 |
VFA | 0.010 | 0.002 | 1.010(1.007,1.013) | 39.841 | 0.001 |
SFA | 0.009 | 0.001 | 1.009(1.006,1.011) | 55.291 | 0.001 |
FPG | 0.059 | 0.021 | 1.061(1.019,1.105) | 8.208 | 0.004 |
HbA1c | 0.165 | 0.034 | 1.180(1.103,1.261) | 23.327 | 0.001 |
TG | 0.109 | 0.026 | 1.116(1.060,1.174) | 17.548 | 0.001 |
TC | 0.058 | 0.041 | 1.060(0.978,1.148) | 2.030 | 0.154 |
HDL-C | -1.010 | 0.225 | 0.364(0.234,0.566) | 20.191 | 0.001 |
LDL-C | -0.026 | 0.068 | 0.974(0.852,1.113) | 0.151 | 0.698 |
HGI | 0.292 | 0.055 | 1.339(1.202,1.491) | 28.177 | 0.001 |
Table 2 Univariate Logistic regression analysis of influencing factors of hyperuricemia in patients with T2DM
项目 | β | SE | OR(95%CI) | Wald χ2值 | P值 |
---|---|---|---|---|---|
性别 | 0.102 | 0.133 | 1.107(0.853,1.438) | 0.583 | 0.445 |
年龄 | 0.035 | 0.007 | 1.036(1.023,1.050) | 28.388 | 0.001 |
T2DM病程 | 0.001 | 0.001 | 1.001(0.999,1.002) | 0.947 | 0.331 |
吸烟史 | -0.218 | 0.237 | 0.804(0.506,1.279) | 0.848 | 0.357 |
饮酒史 | 0.056 | 0.144 | 1.058(0.797,1.403) | 0.152 | 0.696 |
高血压病史 | 0.628 | 0.135 | 1.874(1.438,2.442) | 21.649 | 0.001 |
身高 | 0.018 | 0.008 | 1.018(1.003,1.034) | 5.230 | 0.022 |
体质量 | 0.037 | 0.006 | 1.038(1.027,1.050) | 42.791 | 0.001 |
腰围 | 0.050 | 0.007 | 1.051(1.037,1.065) | 52.841 | 0.001 |
臀围 | 0.047 | 0.009 | 1.048(1.029,1.067) | 26.201 | 0.001 |
BMI | 0.133 | 0.020 | 1.143(1.100,1.187) | 46.488 | 0.001 |
DBP | 0.026 | 0.006 | 1.027(1.014,1.039) | 17.220 | 0.001 |
SBP | 0.013 | 0.003 | 1.013(1.007,1.020) | 15.991 | 0.001 |
VFA | 0.010 | 0.002 | 1.010(1.007,1.013) | 39.841 | 0.001 |
SFA | 0.009 | 0.001 | 1.009(1.006,1.011) | 55.291 | 0.001 |
FPG | 0.059 | 0.021 | 1.061(1.019,1.105) | 8.208 | 0.004 |
HbA1c | 0.165 | 0.034 | 1.180(1.103,1.261) | 23.327 | 0.001 |
TG | 0.109 | 0.026 | 1.116(1.060,1.174) | 17.548 | 0.001 |
TC | 0.058 | 0.041 | 1.060(0.978,1.148) | 2.030 | 0.154 |
HDL-C | -1.010 | 0.225 | 0.364(0.234,0.566) | 20.191 | 0.001 |
LDL-C | -0.026 | 0.068 | 0.974(0.852,1.113) | 0.151 | 0.698 |
HGI | 0.292 | 0.055 | 1.339(1.202,1.491) | 28.177 | 0.001 |
项目 | β | SE | OR(95%CI) | Wald χ2值 | P值 |
---|---|---|---|---|---|
年龄 | 0.047 | 0.009 | 1.048(1.029,1.067) | 25.947 | 0.001 |
高血压病史 | 0.179 | 0.166 | 1.196(0.863,1.657) | 1.152 | 0.283 |
身高 | 0.039 | 0.065 | 1.040(0.915,1.181) | 0.360 | 0.548 |
体质量 | -0.008 | 0.078 | 0.992(0.852,1.155) | 0.012 | 0.914 |
腰围 | -0.024 | 0.018 | 0.977(0.943,1.012) | 1.720 | 0.190 |
臀围 | 0.001 | 0.015 | 1.001(0.971,1.032) | 0.004 | 0.951 |
BMI | 0.095 | 0.203 | 1.099(0.738,1.637) | 0.218 | 0.641 |
DBP | 0.017 | 0.011 | 1.017(0.995,1.040) | 2.257 | 0.133 |
SBP | -0.004 | 0.006 | 0.996(0.984,1.008) | 0.425 | 0.514 |
VFA | 0.001 | 0.002 | 1.001(0.997,1.006) | 0.261 | 0.610 |
SFA | 0.006 | 0.002 | 1.006(1.001,1.010) | 6.577 | 0.010 |
TG | 0.091 | 0.030 | 1.096(1.034,1.161) | 9.507 | 0.002 |
HDL-C | -0.580 | 0.276 | 0.560(0.326,0.961) | 4.429 | 0.035 |
HGI | 0.308 | 0.061 | 1.360(1.208,1.531) | 25.818 | 0.001 |
Table 3 Multivariate Logistic regression analysis of influencing factors of hyperuricemia in patients with T2DM
项目 | β | SE | OR(95%CI) | Wald χ2值 | P值 |
---|---|---|---|---|---|
年龄 | 0.047 | 0.009 | 1.048(1.029,1.067) | 25.947 | 0.001 |
高血压病史 | 0.179 | 0.166 | 1.196(0.863,1.657) | 1.152 | 0.283 |
身高 | 0.039 | 0.065 | 1.040(0.915,1.181) | 0.360 | 0.548 |
体质量 | -0.008 | 0.078 | 0.992(0.852,1.155) | 0.012 | 0.914 |
腰围 | -0.024 | 0.018 | 0.977(0.943,1.012) | 1.720 | 0.190 |
臀围 | 0.001 | 0.015 | 1.001(0.971,1.032) | 0.004 | 0.951 |
BMI | 0.095 | 0.203 | 1.099(0.738,1.637) | 0.218 | 0.641 |
DBP | 0.017 | 0.011 | 1.017(0.995,1.040) | 2.257 | 0.133 |
SBP | -0.004 | 0.006 | 0.996(0.984,1.008) | 0.425 | 0.514 |
VFA | 0.001 | 0.002 | 1.001(0.997,1.006) | 0.261 | 0.610 |
SFA | 0.006 | 0.002 | 1.006(1.001,1.010) | 6.577 | 0.010 |
TG | 0.091 | 0.030 | 1.096(1.034,1.161) | 9.507 | 0.002 |
HDL-C | -0.580 | 0.276 | 0.560(0.326,0.961) | 4.429 | 0.035 |
HGI | 0.308 | 0.061 | 1.360(1.208,1.531) | 25.818 | 0.001 |
项目 | β | SE | OR(95%CI) | Wald χ2值 | P值 | |
---|---|---|---|---|---|---|
HGI三分位数(以低HGI组为参照) | ||||||
中HGI组 | 0.618 | 0.188 | 1.855(1.283,2.681) | 10.799 | 0.001 | |
高HGI组 | 0.785 | 0.184 | 2.192(1.530,3.141) | 18.275 | 0.001 | |
年龄 | 0.039 | 0.007 | 1.040(1.025,1.055) | 28.306 | 0.001 | |
SFA | 0.008 | 0.001 | 1.008(1.005,1.010) | 37.402 | 0.001 | |
TG | 0.088 | 0.028 | 1.092(1.032,1.154) | 9.523 | 0.002 | |
HDL-C | -0.750 | 0.256 | 0.473(0.286,0.781) | 8.546 | 0.003 |
Table 4 Logistic regression analysis of the risk of hyperuricemia in hemoglobin glycation index tertile groups of patients with T2DM
项目 | β | SE | OR(95%CI) | Wald χ2值 | P值 | |
---|---|---|---|---|---|---|
HGI三分位数(以低HGI组为参照) | ||||||
中HGI组 | 0.618 | 0.188 | 1.855(1.283,2.681) | 10.799 | 0.001 | |
高HGI组 | 0.785 | 0.184 | 2.192(1.530,3.141) | 18.275 | 0.001 | |
年龄 | 0.039 | 0.007 | 1.040(1.025,1.055) | 28.306 | 0.001 | |
SFA | 0.008 | 0.001 | 1.008(1.005,1.010) | 37.402 | 0.001 | |
TG | 0.088 | 0.028 | 1.092(1.032,1.154) | 9.523 | 0.002 | |
HDL-C | -0.750 | 0.256 | 0.473(0.286,0.781) | 8.546 | 0.003 |
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