Abstract: Background　Rotavirus enteritis is a main cause of diarrhea among infants.It is an epidemic more commonly happened in autumn and winter，which can cause damage to the digestive system such as the gastrointestinal tract and liver，and to multiple systems such as breathing，circulation，and nerves，and can lead to death in severe cases.Rotavirus enteritis with central nervous system damage can cause symptoms such as convulsion，coma，and limb paralysis，of which convulsion is the most common，but the pathogenesis is not fully clear.To reduce the possibility of developing convulsion and brain damage associated with rotavirus enteritis，it is of great clinical significance to identify high risk factors of convulsion and timely deliver interventions based on analyzing its causes and clinical manifestations.Objective　To explore the influencing factors of rotavirus enteritis complicated with convulsions in infants.Methods　One hundred and thirty-four infants with rotavirus enteritis（including 47 with convulsions and 87 without）were recruited from Department of Pediatric Medicine，Weifang People's Hospital from January 2018 to December 2019.After admission，fecal sample was collected for performing rotavirus antigen test using ELISA.Fasting venous blood sample was collected for performing routine and biochemical blood tests.Mid-stream urine sample was collected for performing routine urine test.Information was recorded，including sex，age，vomiting frequency，diarrhea frequency，status of fever and dehydration，levels of serum sodium，potassium，chlorine and calcium，glucose，CO2-binding capacity，creatine kinase isoenzyme MB（CK-MB）and other indicators.Multivariate logistic regression analysis was used to explore the influencing factors of rotavirus enteritis complicated with convulsions.Results　Rotavirus enteritis infants with convulsions had much more diarrhea frequencies and higher serum CK-MB，and lower fever prevalence，and lower levels of serum calcium，glucose and CO2-binding capacity compared to those without（P<0.05）.Multivariate logistic regression analysis showed that fever 〔OR=0.131，95%CI（0.045，0.383）〕，serum calcium 〔OR=66.923，95%CI（5.630，795.468）〕，serum glucose 〔OR=1.958，95%CI（1.316，2.915）〕，and CK-MB〔OR=0.989，95%CI（0.979，1.000）〕 were associated with rotavirus enteritis complicated with convulsions（P<0.05）.Conclusion　Diarrhea frequency，status of fever，serum levels of calcium，glucose，CO2-binding capacity and CK-MB，especially status of fever，serum calcium，glucose and CK-MB，may affect the occurrence of convulsions in rotavirus enteritis in infants.To prevent convulsion incidence，it is suggested to analyze the patient's detailed medical history and biochemical examination results to early identify risk factors for convulsions and deliver targeted interventions timely.

Key words: Rotavirus infections, Convulsions, Infants, Enteritis, Root cause analysis

摘要： 背景　轮状病毒肠炎是引起婴幼儿腹泻主要原因，多见于秋冬季节，呈流行性，可导致胃肠道、肝脏等消化系统损害，还可并发呼吸、循环、神经等多个系统损害，重者可致死亡。轮状病毒肠炎并发中枢神经系统损害可出现惊厥、昏迷、肢体瘫痪等症状，其中惊厥是最常见表现，发病机制尚不完全明确。因此，探讨轮状病毒肠炎并发惊厥原因及临床特点，及早发现并发惊厥相关高危因素，进行早期干预治疗，对预防惊厥发生，减轻脑损害具有重要临床意义。目的　探讨轮状病毒肠炎患儿并发惊厥的影响因素。方法　选择2018年1月—2019年12月在潍坊市人民医院小儿内科住院诊断为轮状病毒肠炎患儿134例为研究对象，根据患儿是否发生惊厥分为惊厥组（47例）与非惊厥组（87例），患儿入院后留取粪便样本，进行大便RV抗原检测（酶联免疫吸附试验法）。取空腹静脉血，进行血常规、生化、尿常规检测。记录患儿性别、年龄、呕吐次数、腹泻次数、发热发生率、脱水情况、血钠、血钾、血氯、血钙、血糖、二氧化碳结合力、肌酸激酶同工酶（CK-MB）等指标。采用多因素Logistic回归分析探讨轮状病毒肠炎并发惊厥的影响因素。结果　惊厥组患儿腹泻次数、CK-MB高于非惊厥组患儿，发热发生率、血钙、血糖、二氧化碳结合力低于非惊厥组患儿（P<0.05）。多因素Logistic回归分析结果显示，发热〔OR=0.131，95%CI（0.045，0.383）〕、血钙〔OR=66.923，95%CI（5.630，795.468）〕、血糖〔OR=1.958，95%CI（1.316，2.915）〕、CK-MB〔OR=0.989，95%CI（0.979，1.000）〕为RV肠炎并发惊厥的影响因素（P<0.05）。结论　腹泻次数、发热、血钙、血糖、二氧化碳结合力及CK-MB等指标，特别是发热、血钙、血糖及CK-MB变化可能影响惊厥发生。因此，仔细询问病史，及时完善生化检查，及早发现相关危险因素对症治疗，可预防惊厥发生。

关键词: 轮状病毒感染, 惊厥, 婴幼儿, 肠炎, 影响因素分析