Abstract: Background　The number of people suffering from cardiovascular disease in China is increasing with the aggravation of aging.Hypertension is the most common cardiovascular disease，often accompanied by damage to target organs such as the heart，brain and kidney.Left ventricular hypertrophy（LVH） is the most common major complication of hypertension，which is closely related to blood pressure levels.Objective　To investigate the correlation of different blood pressure with LVH in patients with essential hypertension.Methods　497 inpatients with hypertension were recruited from the Department of Hypertension，the First Affiliated Hospital of Xinjiang Medical University from January 2012 to December 2018.According to the left ventricular mass index（LVMI），they were divided into non-LVH group（367 cases） and LVH group（130 cases）.The clinical data，indoor blood pressure，central aortic blood pressure related indicators and 24-hour ambulatory blood pressure were collected to analyze their correlations with LVMI，and the influencing factors of LVH.Results　There were statistically significant differences in gender ratio，mean values of age，triglyceride，and admission systolic blood pressure（SBP），diastolic blood pressure（DBP），central aortic SBP，central aortic DBP，24 hSBP，24 hDBP and 24 h pulse pressure（24 hPP） between the two groups（P<0.05）.LVMI was positively correlated with SBP，DBP，central aortic SBP and DBP，central aortic pulse pressure，24 hSBP，24 hDBP，and 24 hPP（P<0.05）.Stepwise multiple linear regression analysis showed that serum cystatin C，central aortic SBP and 24 hSBP were associated with LVH（P<0.05）.Conclusion　LVH is related to indoor blood pressure and central aortic pressure in patients with hypertension.Serum cystatin C，central aortic SBP and 24 hSBP are the influencing factors of LVH.

Key words: Hypertension, Left ventricular hypertrophy, Central arterial pressure, Blood pressure, Correlation study

摘要： 背景　随着人口老龄化的日益严重，我国心血管疾病的人数日渐增多，高血压作为最常见的心血管疾病，常伴随着心、脑、肾等靶器官的损害，左心室肥厚（LVH）是高血压最常见也是最主要的并发症，与血压水平密切相关。目的　探讨原发性高血压病（简称高血压）患者不同血压与LVH的相关性。方法　选择2012年1月—2018年12月在新疆医科大学第一附属医院高血压科住院的高血压患者497例，根据左心室质量指数（LVMI）分为非左心室肥厚（NLVH）组367例及LVH组130例。收集患者的临床资料、外周血压、中心动脉压相关指标、24 h动态血压，分析上述指标与LVMI的相关性和LVH的影响因素。结果　两组患者性别、年龄、三酰甘油（TG）、入院收缩压（SBP）、舒张压（DBP）及中心动脉收缩压（CSBP）、中心动脉舒张压（CDBP）、24 hSBP、24 hDBP、24 h脉压（PP）比较，差异均有统计学意义（P<0.05）。LVMI与SBP、DBP、CSBP、CDBP、中心动脉脉压（CPP）、24 hSBP、24 hDBP、24 hPP呈正相关（P<0.05）。多元线性逐步回归分析结果显示，血清胱抑素C、CSBP、24 hSBP是LVH的影响因素（P<0.05）。结论　高血压患者LVH与外周血压、中心动脉压相关，血清胱抑素C、CSBP、24 hSBP是LVH的影响因素。

关键词: 高血压, 左心室肥厚, 中心动脉压, 血压, 相关性研究