Abstract: Background　Hyperuricemia（HUA）and hypertension are important controllable risk factors for cardiovascular and cerebrovascular diseases.They often coexist with other cardiovascular risk factors，and accelerate the progression of cardiovascular disease.Objective　To investigate the incidence and influencing factors of HUA in hypertensive populations.Methods　We enrolled 3 930 physical examinees with hypertension from a physical examination center of Beijing from 2012 to 2016，and followed up them for 1 to 4 years.We analyzed the incidence of HUA in these participants，and compared the demographic，physical and laboratory data between non-HUA and HUA groups，and analyzed the influencing factors of HUA by using Logistic stepwise regression.Results　The incidence of HUA in the participants was 23.31%（916/3 930）．Sex-specific analysis showed that the incidence of HUA was higher in males than that in females〔24.76%（742/2 997） vs 18.65%（174/933），χ2=14.853，P<0.001〕．Age-specific analysis indicated that the incidence of HUA was 25.67%（295/1 149），21.76%（363/1 668），21.44%（149/695） and 26.08%（109/418） in age groups of <45，45-<60，60-<75 and ≥75，respectively.There was no significant difference in the cumulative incidence of HUA among different age groups（χ2=0.467，P=0.495）．Compared with non-HUA group，HUA group showed higher proportion of males，higher mean levels of WBC，GGT，creatinine，triglyceride，uric acid，BMI，and waist-hip ratio，and lower mean ALT，HDL-C and FBG levels（P<0.05）．Stepwise Logistic regression analysis showed that creatinine，HDL-C，triglyceride，FBG，erythrocyte sedimentation rate and obesity were factors associated with HUA in hypertensive populations（P<0.05），and hemoglobin，creatinine，HDL-C，triglyceride，FBG and obesity were factors associated with HUA in hypertensive men（P<0.05），and age，total cholesterol and obesity were factors associated with HUA in hypertensive women（P<0.05）．Conclusion　The incidence of HUA does not increase with age in hypertensive populations.Factors associated with HUA in this group include creatinine，HDL-C，triglyceride，FBG，erythrocyte sedimentation rate，and obesity .Sex differences are also found in factors affecting the incidence of HUA.

Key words: Hypertension, Hyperuricemia, Cohort study, Root cause analysis

摘要： 背景　高尿酸血症（HUA）和高血压都是心脑血管疾病重要的可控危险因素，常与其他心血管危险因素并存，加速心血管病的进程。目的　探讨高血压人群HUA发病情况及影响因素。方法　随访北京市某体检中心2012—2016年3 930例高血压患者1~4年，分析其HUA的发病水平，比较非HUA组与HUA组人口统计、体格检查、实验室检查资料，并采用Logistic逐步回归分析高血压患者HUA发病的影响因素。结果　高血压人群HUA的发病率为23.31%（916/3 930），男性高于女性〔24.76%（742/2 997）比18.65%（174/933），χ2=14.853，P<0.001）〕。<45、45~<60、60~<75、≥75岁年龄组HUA的发病率分别为25.67%（295/1 149）、21.76%（363/1 668）、21.44%（149/695）、26.08%（109/418）。不同年龄段高血压患者HUA累积发病率比较，差异无统计学意义（χ2=0.467，P=0.495）。HUA组男性占比、白细胞计数、γ-谷氨酰转移酶、肌酐、三酰甘油、尿酸、体质指数、腰臀比高于非HUA组，丙氨酸氨基转移酶、高密度脂蛋白胆固醇、空腹血糖低于非HUA组，差异有统计学意义（P<0.05）。Logistic逐步回归分析结果显示，影响高血压人群进展为HUA的因素有肌酐、高密度脂蛋白胆固醇、三酰甘油、空腹血糖、红细胞沉降率、是否肥胖（P<0.05）；男性HUA发病的影响因素有血红蛋白、肌酐、高密度脂蛋白胆固醇、三酰甘油、空腹血糖、是否肥胖（P<0.05）；女性HUA发病的影响因素有年龄、总胆固醇、是否肥胖（P<0.05）。结论　高血压人群HUA的发病水平随年龄增加未呈现增高趋势。影响高血压人群进展为HUA的因素包括肌酐、高密度脂蛋白胆固醇、三酰甘油、空腹血糖、红细胞沉降率及是否肥胖；男性和女性的HUA发病影响因素存在差异。

关键词: 高血压, 高尿酸血症, 队列研究, 影响因素分析