Research Progress on High Cholesterol and Osteoarthritis

doi:10.12114/j.issn.1007-9572.2019.00.178

Abstract

Abstract: Studies have shown that osteoarthritis is not only affected by aging，but also affected by a variety of other factors.One of the risk factors may be high cholesterol level in the body.Although high cholesterol has been shown to promote cardiovascular diseases，its role in musculoskeletal disorders，especially osteoarthritis，is unclear.This paper will discuss how high cholesterol affects osteoarthritis and the molecular mechanisms by which it affects.This will be a new research direction and will provide a new strategy for the prevention and treatment of osteoarthritis.

Key words: Osteoarthritis, Hypercholesterolemia, Oxidative stress, Review

摘要： 研究指出，骨关节炎不仅受衰老影响，还受多种因素共同影响。其中一个危险因素可能是体内高胆固醇水平。尽管研究已经明确高胆固醇会促进心血管疾病的发生，但其在肌肉骨骼疾病，尤其是骨关节炎中的作用尚不清楚。本文将讨论高胆固醇如何影响骨关节炎，并介绍通过哪些分子机制对其产生影响。这将是一个新的研究方向，并对骨关节炎的防治及药物治疗提供新的策略。

关键词: 骨关节炎, 高胆固醇血症, 氧化应激, 综述

HAN Guangtao,LI Haohuan,CAI Weisong, et al. Research Progress on High Cholesterol and Osteoarthritis　[J]. Chinese General Practice, 2019, 22(32): 4015-4019. DOI: 10.12114/j.issn.1007-9572.2019.00.178.
韩广弢,李皓桓,蔡伟松等. 高胆固醇与骨关节炎的研究进展[J]. 中国全科医学, 2019, 22(32): 4015-4019. DOI: 10.12114/j.issn.1007-9572.2019.00.178.

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