Content of Original Research·Hot Topics·Enteropathy in our journal

Published in last 1 year |  In last 2 years |  In last 3 years |  All Please wait a minute... For Selected: Download Citations EndNote Ris BibTeX Toggle Thumbnails Select Advances in Energy Metabolism Regulation of Intestinal Stem Cell Function and the Therapeutic Advantages of Traditional Chinese Medicine ZHU Yan, XIAO Jin, YANG Yang, TANG Taichun, WANG Shuting, CHEN Siqi, CHEN Min Chinese General Practice    2024, 27 (23): 2853-2857.   DOI: 10.12114/j.issn.1007-9572.2023.0676 Abstract （284）   HTML （2）    PDF（pc） （1399KB）（244）       Knowledge map    Save Intestinal stem cells are an important part of maintaining the stability of intestinal barrier function, which is closely related to intestinal homeostasis, intestinal epithelial renewal, and repair of intestinal damage. Normal physiological activities of the human body cannot be separated from energy intake and metabolism, and the differentiation fate of stem cells is affected by energy metabolism, and impaired intestinal barrier is associated with the development of many intestinal diseases. Therefore, this paper focuses on intestinal stem cells, takes energy metabolism and metabolites as the background to investigate how energy metabolism and metabolites regulate the function and activity of stem cells, thus regulating the function of intestinal barrier and providing ideas for the treatment of various intestinal diseases; in addition, with the in-depth research of modern medical science in protecting intestinal barrier, the theory of traditional Chinese medicine (TCM) that cares for spleen and stomach is gradually showing its scientific validity, with the hope of providing ideas for the subsequent research. Reference | Related Articles | Metrics Select Progress of Research on Mechanism of Intestinal Nervous System Regulating Intestinal Inflammation Based on Intestinal Stem Cells CHEN Siqi, XIAO Jin, TIAN Siyu, ZHANG Jia, WANG Shuting, ZHANG Xindan, ZHU Yan, CHEN Min Chinese General Practice    2024, 27 (23): 2858-2863.   DOI: 10.12114/j.issn.1007-9572.2023.0245 Abstract （365）   HTML （3）    PDF（pc） （1540KB）（1271）       Knowledge map    Save Intestinal stem cells are regulated by the intestinal nervous system, and both of them are closely related to intestinal inflammation. Relevant studies have shown the existence of intestinal nerve dysfunction in intestinal inflammation. By summarizing the relationship among intestinal stem cells, intestinal nervous system and intestinal inflammation, this paper discusses that intestinal nervous system injury related to intestinal inflammation may be the basis for persistent alteration of intestinal function, while enteric neurons provide feasible targets for improving intestinal nerve dysfunction in inflammatory bowel diseases, so as to apply various types of stem cells to the improvement of intestinal nerve dysfunction in intestinal inflammation. Table and Figures | Reference | Related Articles | Metrics Select Advances in Exploring the Interaction between Paneth Cells and Intestinal Stem Cells and Possible Targets for Traditional Chinese Medicine Based on Mitochondrial Function and Energy Metabolism LUO Guoliang, ZHANG Xindan, TANG Taichun, ZHU Yan, WANG Shuting, CHEN Min Chinese General Practice    2024, 27 (23): 2864-2868.   DOI: 10.12114/j.issn.1007-9572.2023.0574 Abstract （307）   HTML （2）    PDF（pc） （1497KB）（1939）       Knowledge map    Save Intestinal stem cells and Paneth cells interact with each other to maintain intestinal homeostasis and function, the interaction between intestinal stem cells and Paneth cells is regulated by mitochondria-related functions and energy conversion. The unique advantages of traditional Chinese medicine (TCM) in the treatment of intestinal diseases are also reflected in its effects on mitochondria and energy metabolism. This paper explores the influence of mitochondrial function and energy metabolism on the interaction between intestinal stem cells and Paneth cells, as well as the possible targets related to mitochondria in the treatment of intestinal diseases by TCM, summarizes the regulatory effects of TCM on mitochondria and energy metabolism, thereby restoring intestinal homeostasis and alleviating disease, with an aim to provide reference and theoretical basis for the research related to the TCM treatment of intestinal stem cells and Paneth cells based on mitochondria. Table and Figures | Reference | Related Articles | Metrics