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    Timing of Antihypertensive Initiation in Gestational Hypertension—Early Intervention Can Reducec Clinical Risk
    Na LI, Wenli CHENG
    Chinese General Practice    2022, 25 (30): 3733-3738.   DOI: 10.12114/j.issn.1007-9572.2022.0517
    Abstract921)   HTML18)    PDF(pc) (1753KB)(512)       Save

    Gestational hypertensionis a serious adverse factor that endangers the health of women during pregnancy and the growth and development of the fetus. The incidence of gestational hypertension in pregnant women in China is 6% to 8%, with the liberalization of the fertility policy in China, the average age of pregnant women has increased, and risk factors such as overweight, obesity, and diabetes have generally increased, the potential risk of gestational hypertension is more prominent among them. In the diagnosis of gestational hypertension, the opinions of international experts are relatively consistent that ≥140/90 mm Hg is the threshold for diagnosing gestational hypertension, but there is still few high-level studies can be used as the evidence supporting the time to start antihypertensive treatment. In recent years, the recommendations of various hypertension academic organizations on the treatment and control target value of pregnant women with chronic hypertension have also been controversial. This article elaborates on the harm of gestational hypertension and the time to initiate blood pressure reduction, analyzes the early intervention effect of gestational hypertension and new methods for the prevention and treatment of gestational hypertension, in order to provide clinical evidence for the antihypertensive treatment of gestational hypertension.

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    Application of Minimal Clinically Important Difference in Outcome Assessment Tools for Bronchiectasis Treatment
    Jiarui GUAN, Jiaming REN, Yang XIE, Peng ZHANG
    Chinese General Practice    2022, 25 (30): 3739-3746.   DOI: 10.12114/j.issn.1007-9572.2022.0290
    Abstract857)   HTML14)    PDF(pc) (2208KB)(402)       Save

    Increased bronchiectasis (BE) prevalence has imposed heavy economic burden on patients and their families, greatly affecting the quality of life of patients. With increased use of patient reported outcome (PRO) in bronchiectasis treatment assessment, researchers not only focus on statistical pre-and post-treatment differences (P<0.05) , but also pay attention to minimal clinically important difference (MCID) . Currently, there is still a lack of relevant data about MCID in BE-PRO assessment tools. We reviewed the latest research on the use of MCID in BE-PRO assessment tools, aiming at providing a quantitative basis for outcome assessment in BE treatment.

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    Consensus and Disagreement in the Debate on the Bidirectional Effects of Alcohol Consumption on the Cardiovascular System
    Jinxia REN, Leiming LUO
    Chinese General Practice    2022, 25 (30): 3747-3754.   DOI: 10.12114/j.issn.1007-9572.2022.0299
    Abstract1183)   HTML23)    PDF(pc) (2074KB)(600)       Save

    Today's world, there is an increasing number of people drinking alcoholic beverages. Drinking alcohol can induce several diseases and is a serious threat to human health, but whether it has a positive effect on the cardiovascular system is controversial. Traditional beliefs have suggested that small to moderate amounts of alcohol consumption (female intake of ≤ 1 standard amounts of alcoholic beverages daily, male intake of ≤ 2 standard amounts of alcoholic beverages daily, 1 standard amounts of alcoholic beverages=12-15 g pure ethanol) might be beneficial for the treatment of cardiovascular diseases (such as atherosclerotic cardiovascular disease) , whereas heavy drinking (intake of > 2 standard amounts of alcoholic beverages daily) leads to impairment of the cardiovascular system, the bidirectional effect of a "J" - shaped curve. In recent years, there has been a growing debate on whether traditional ideas are correct, involving many aspects such as the pattern of drinking, the type of alcoholic beverage and the different types of CVD that they affect. This article discusses the consensus and disagreement in the debate on bidirectional effects of drinking on cardiovascular system by pooling and analyzing recent results from relevant studies at home and abroad, finding that although there is no consistent view in the current relevant studies, most research results suggest that small to moderate alcohol consumption may benefit cardiovascular health, especially in middle-aged and elderly people with pre-existing atherosclerosis and cardiovascular disease. It may provide ideas for developing lifestyle intervention guidelines for cardiovascular disease prevention and control in the future.

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