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    Blood Pressure Control Goals in Elderly Patients with HypertensionEvidence from Latest Clinical Studies

    LIU Kaixuan, GUO Yifang
    Chinese General Practice    2022, 25 (11): 1305-1308.   DOI: 10.12114/j.issn.1007-9572.2022.01.303
    Abstract902)   HTML27)    PDF(pc) (964KB)(404)       Save

    Due to the lack of relevant research evidence, the optimal blood pressure target in elderly hypertensive patients has been controversial for a long time. Many scholars believe that the elderly have poor tolerance to antihypertensive treatment, so their blood pressure control goal should bemore relaxed. However, the latest research evidence published in recent years shows that there may be more benefits from controlling systolic blood pressure in older adults to <130 mmHg. It is expected that these new research conclusions will have an important impact on the revision of guidelines in the future.

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    The Incubation Period of COVID-19 Caused by Different SARS-CoV-2 Variants

    WU Yu, LIU Min
    Chinese General Practice    2022, 25 (11): 1309-1313.   DOI: 10.12114/j.issn.1007-9572.2022.0078
    Abstract1381)   HTML62)    PDF(pc) (441KB)(1007)       Save

    Since the beginning of the COVID-19 epidemic, the pathogen of COVID-19, SARS-CoV-2, has evolved and mutated continuously, producing variants with different enhanced transmission and virulence, such as Alpha (B.1.1.7) , Beta (B.1.351) , Gamma (P.1) , Delta (B.1.617.2) and Omicron (B.1.1.529) . An intensive study of the incubation period of COVID-19 caused by different SARS-CoV-2 variants will contribute to tracing the origin of COVID-19, determining the detention, quarantine and isolation time of close contacts, and timely improving measures for containing COVID-19. We reviewed the major studies on the incubation period of COVID-19 caused by wild-type strains and different variants of SARS-CoV-2, which estimated that the incubation period of COVID-19 caused by wild-type SARS-CoV-2 strains was 4-8 (median 5.5) days. And that for COVID-19 caused by Beta or Gamma variant was generally similar to that by wild-type strains, about 5 days. The incubation period of COVID-19 caused by Alpha, Delta and Omicron variants was shorter than that of other strains, which was 4, 4 and 3 days, respectively.

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    Research Status and Thinking of Minimal Clinically Important Difference in Patient-reported Outcome Assessment Tool for Allergic Rhinitis

    ZHANG Peng, REN Jiaming, GUAN Jiarui, XIE Yang
    Chinese General Practice    2022, 25 (11): 1314-1319.   DOI: 10.12114/j.issn.1007-9572.2021.01.502
    Abstract626)   HTML11)    PDF(pc) (1031KB)(340)       Save

    As the patient-reported outcome (PRO) assessment tool has been increasingly used in the clinical efficacy evaluation of patients with allergic rhinitis (AR) , the judgment and interpretation of changes in measurement results of assessment tools have become increasingly important. For the judgment of clinical research results, not only the statistical differences, but also the minimum clinically important difference (MCID) must be paid attention to. This paper systematically sorts out the MCID of the AR-PRO assessment tool, in order to provide a reference for AR-related clinical diagnosis and treatment decision-making and the objectification of the PRO assessment tool.

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