Relationship between Vitamin K and Glucose Metabolism

doi:10.12114/j.issn.1007-9572.2019.00.551

Abstract

Abstract: Diabetes is a worldwide public health disease that poses a threat to human health.Vitamin K could act on insulin resistance and glucose metabolism via vitamin K-dependent proteins （VKDPS）——osteocalcin （OC），growth arrest-specific 6 protein （Gas-6），and matrix Gla protein （MGP） and adiponectin，inflammatory factors and lipid，which may provide new ideas for the treatment of diabetes.The relationship between vitamin K and glucose metabolism has been tested in many animal experimentations and clinical experiments.

Key words: Vitamin K, Glucose metabolism, Diabetes mellitus, Insulin resistance, Review

摘要： 糖尿病是威胁人类健康的世界性公共卫生问题，维生素K通过介导维生素K依赖蛋白（VKDPS）—骨钙素（OC）、生长抑制因子6（Gas-6）、羧基谷氨酸蛋白（MGP）以及脂联素、炎性因子及脂质变化来影响胰岛素抵抗及糖代谢，这可能给糖尿病治疗提供了新思路。维生素K与糖代谢的关系已在许多动物实验及临床试验中得到证实。

关键词: 维生素K, 糖代谢, 糖尿病, 胰岛素抵抗, 综述

REN Ruijun,TAN Jing. Relationship between Vitamin K and Glucose Metabolism　[J]. Chinese General Practice, 2019, 22(29): 3539-3543. DOI: 10.12114/j.issn.1007-9572.2019.00.551.
任芮君,谭竞. 维生素K与糖代谢研究进展[J]. 中国全科医学, 2019, 22(29): 3539-3543. DOI: 10.12114/j.issn.1007-9572.2019.00.551.

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