Abstract: Background　Cervical spondylotic radiculopathy（CSR） is the most common type of cervical spondylosis in clinic. Its main symptom is nerve root pain caused by nerve root compression. Ozone combined with radiofrequency ablation is a common interventional therapy for the treatment of Cervical Spondylotic Radiculopathy. However, there is no unified standard on the concentration of ozone injection at home and abroad.Objective　To investigate the early efficacy of different concentrations of ozone combined with radiofrequency ablation in the treatment of CSR．Methods　A total of 45 CSR patients who met the inclusion criteria in Department of Orthopedics from the First Affiliated Hospital of Guangxi University of Traditional Chinese Medicine from January 2016 to January 2017 were selected.They were randomly divided into low concentration group （A group，20 mg/L），moderate concentration group （B group，40 mg/L） and high concentration group （C group，60 mg/L），each with 15 cases.Radiofrequency ablation combined with ozone injection of 20, 40 and 60 mg/L was given to group A, B and C in turn.The visual analogue score（VAS） and neck disability index（NDI） were compared in each group before and at 1 day，
1 month，3 months and 6 months after operation.Results　Treatment method and time had interactive effect on VAS and NDI score （P<0.05），and the main effect of treatment method and time on VAS，NDI score was significant （P<0.05）；VAS and NDI scores of the 3 groups were lower than those before operation at 1 day，1 month，3 months and 6 months after operation （P<0.05）．VAS and NDI score of group B was lower than that of group A at 1 day and 1 month after operation （P<0.05）．The VAS score of group C was higher than that of group A at 1 day，1 months and 6 months after operation，and NDI score at 1 day and 1 month after operation was higher than that of group A （P<0.05）．VAS score of group C was higher than that of group B at 1 day，1 month，3 months and 6 months after operation，and NDI score at 1 day，1 month and 3 months after operation was higher than that of group B （P<0.05）．Conclusion　Moderate concentration （40 mg/L） of ozone combined with radiofrequency ablation is the best treatment method for CSR.

Key words: Cervical spondylosis, Radiculopathy, Ozone, Catheter ablation, Comparative effectiveness research

摘要： 背景　神经根型颈椎病（CSR）是临床中最常见的一类颈椎病，其主要症状是由于神经根受压导致的神经根性疼痛，臭氧联合射频消融术是治疗CSR常用的方法，但是关于臭氧注射的浓度，目前国内外尚无统一的标准。目的　探讨不同浓度臭氧联合射频消融术治疗CSR的临床疗效。方法　选取2016年1月—2017年1月于广西中医药大学第一附属医院骨科（脊柱外科）就诊的符合纳入标准的CSR患者45例，依据随机数字表法将其分为低浓度组（A组，20 mg/L）、中浓度组（B组，40 mg/L）、高浓度组（C组，60 mg/L），各15例。A、B、C组依次给予射频消融术联合20、40、60 mg/L臭氧注射治疗。比较各组术前、术后1 d及术后1、3、6个月视觉模拟评分法（VAS）评分及颈椎功能障碍指数量表（NDI）评分。结果　治疗方法与时间对VAS、NDI评分存在交互作用（P<0.05）；治疗方法、时间对VAS、NDI评分的影响主效应显著（P<0.05）。3组术后1 d和术后1、3、6个月VAS、NDI评分均低于术前（P<0.05）。B组术后1 d、术后1个月VAS、NDI评分低于A组（P<0.05）；C组术后1 d和术后1、6个月VAS评分高于A组，术后1 d、术后1个月NDI评分高于A组（P<0.05）；C组术后1 d和术后1、3、6个月VAS评分高于B组，术后1 d和术后1、3个月NDI评分高于B组（P<0.05）。结论　中等浓度（40 mg/L）的臭氧联合射频消融术治疗CSR可以获得最佳疗效。

关键词: 颈椎病, 神经根病, 臭氧, 导管消融术, 疗效比较研究