Abstract: Digestive system neoplasms are tumors with high morbidity and mortality.Tumor markers are implicated in tumor initiation and development，so tumor marker detection is one important method for cancer screening and diagnosis in present day.However，single tumor marker detection is not conducive to the screening and early diagnosis of tumor due to their low sensitivity and specificity.Therefore，it is important to develop notably efficient methods of combined multiple tumor markers detection for the screening and early diagnosis of digestive system neoplasms.This review summarized current studies of combined multiple tumor markers detection in digestive system neoplasms in order to provide the theoretical basis for the evaluation of its clinical application value and development prospect.

Key words: Digestive system neoplasms；Tumor markers, biology；Diagnosis；Review

摘要： 消化系统肿瘤的发病率和死亡率均较高，肿瘤标志物与肿瘤的发生、发展密切相关，因此肿瘤标志物检测是当前进行癌症筛查和诊断的重要方法之一。但单一的肿瘤标志物检测灵敏度和特异度不高，不利于肿瘤的筛查和早期诊断。因此，开发高效的肿瘤标志物联合检测技术对消化系统肿瘤的早期诊断和治疗具有重要意义。本文系统地综述了消化系统肿瘤标志物联合检测的最新进展，为评价其在消化系统肿瘤诊疗方面的临床应用价值和发展前景提供理论依据。

关键词: 消化系统肿瘤, 肿瘤标志物, 生物学, 诊断, 综述