Abstract: Anti-Jo-1 antibody syndrome is a rare chronic autoimmune disorder associated with diverse clinical manifestations.The pathogenesis of this disease is unknown.Lack of understanding of the disease and misinterpretation of symptoms can lead to misdiagnosis，and opportunities for treatment and support would be delayed，which in turn deteriorates the prognosis.We reported two patients with anti-Jo-1 antibody syndrome and reviewed the recent developments in the clinical features，pathogenesis，diagnosis and treatment of anti-Jo-1 antibody syndrome in order to improve the outcome and decrease the mortality of such patients by reducing the probabilities of missed diagnosis and misdiagnosis via enhancing clinicians' understanding of the disease.

Key words: Anti-Jo-1 syndrome；Symptoms &, signs；Diagnosis

摘要： 抗Jo-1抗体综合征在临床上较为少见，由于其临床表现多样、发病机制不明确、临床医师认识不足，导致容易造成漏诊误诊，延误病情，影响患者的治疗和预后。本文报道了2例抗Jo-1抗体综合征患者的临床诊疗经过，并对抗Jo-1抗体综合征的临床特征、发病机制、诊断及治疗进展进行相关文献复习，以提高临床医师对该病的认识，减少漏诊、误诊，改善患者预后，降低病死率。

关键词: 抗Jo-1抗体综合征, 症状和体征, 诊断