Abstract: Objective 　To discuss the clinical efficacy of alternating red and blue light irradiation generated by light emitting diodes（ARBLIGLED），Mucopolysaccharide Polysulfate Cream（MPC） and Xihuang Capsule（XC） for moderate to severe facial acne，and to investigate the degree of improvement in quality of life in these patients.Methods　We enrolled 300 cases of moderate to severe facial acne from the Second Affiliated Hospital of Qiqihar Medical University and Heilongjiang Provincial Hospital from December 2015 to December 2016.Using random number table，we divided them into group A，group B and group C，with 100 in each，treated by ARBLIGLED combined with MPC and XC，ARBLIGLED combined with MPC，ARBLIGLED，respectively.Indicators for clinical efficacy include the number of inflammatory and non-inflammatory skin lesions，and levels of IgG，IgA，IgM，serum complement C3 and C4，IL-2，sIL-2R，and 4 sex hormones（follicle-stimulating hormone，luteinizing hormone，testosterone，estradiol）．Quality of life was assessed by SF-36.Results　After treatment，the number of both inflammatory and non-inflammatory skin lesions decreased significantly in all groups compared with baseline（P<0.05）；levels of IgG，C3，C4 and IL-2 were found to be significantly lower in group A（P<0.05）；the levels of 4 sex hormones were still similar in males or females of all groups（P>0.05）．Compared with other two groups，after treatment，group A achieved better clinical response，which was indicated by much less number of inflammatory and non-inflammatory skin lesions，and significantly lower levels of IgG，C3，C4 and IL-2（P<0.05）．After treatment，group A achieved the highest SF-36 scores，followed by groups B and C（P<0.05）．Conclusion　The combination regimen of ARBLIGLED，MPC and XC has significant effect on moderate to severe facial acne as indicated by much improved immune functions and quality of life.

Key words: Acne vulgaris；Physical therapy modalities；Drug therapy, combination；Treatment outcome

摘要： 目的　探讨红蓝光照射、多磺酸粘多糖乳膏联合西黄胶囊治疗中重度面部痤疮的临床疗效及对生活质量的影响。方法　选取2015年12月—2016年12月齐齐哈尔医学院附属第二医院和黑龙江省医院收治的中重度面部痤疮患者300例。采用随机数字表法将其分为A、B、C组，各100例。C组患者采用传统红蓝光照射治疗，B组患者在C组基础上加用多磺酸粘多糖乳膏治疗，A组患者在红蓝光照射及多磺酸粘多糖乳膏治疗基础上联合应用西黄胶囊治疗。比较3组患者临床疗效，治疗前后炎性皮损、非炎性皮损数目，IgG、IgA、IgM，补体C3、C4，白介素（IL）-2、可溶性白介素2受体（sIL-2R）水平，性激素〔血清促卵泡生成素（FSH）、黄体生成素（LH）、睾酮（T）、雌二醇（E2）〕水平以及生活质量评价量表（SF-36）评分。结果　A组患者临床疗效优于B、C组（P<0.05）。治疗后A组患者炎性皮损、非炎性皮损数目少于B、C组（P<0.05）。治疗后3组患者炎性皮损、非炎性皮损数目均较治疗前减少（P<0.05）。治疗后A组IgG、C3、C4、IL-2水平低于B、C组（P<0.05）。治疗后A组IgG、C3、C4、IL-2水平低于治疗前（P<0.05）。3组男性和女性患者治疗前、后性激素水平组间比较，差异无统计学意义（P>0.05）。治疗后A组患者SF-36评分高于B、C组，B组SF-36评分高于C组（P<0.05）。结论　红蓝光照射、多磺酸粘多糖乳膏联合西黄胶囊治疗中重度面部痤疮疗效显著，能够改善患者的免疫功能，并且对提升患者生活质量具有积极作用。

关键词: 寻常痤疮, 物理治疗技术, 药物疗法, 联合, 治疗结果