Abstract: Background　The detection rate of hyperuricemia is increasing，whose high incidence has brought great harm to public health. Available studies suggest that high uric acid is associated with chronic diseases, and increasing evidence supports that hyperuricemia may be a high risk factor for other chronic diseases. Objective　To analyze the association of hyperuricemia with common chronic diseases in middle-aged and elderly people. Methods　Data came from part of the 2015 China Health and Retirement Longitudinal Survey，involving 9 022 cases（>45 years old） with complete blood test information. Chi-square test was used to compare hyperuricemia prevalence in participants by demographic factors. Multivariate unconditional Logistic regression was used to examine the association between hyperuricemia with common chronic diseases. Results　A total of 1 117 cases（628 men and 489 women） were found with hyperuricemia, accounting for 12.38%. Men had higher hyperuricemia prevalence than women〔14.65%（628/4 287） vs 10.33%（489/4 735）〕（P<0.01）. After adjusting for confounding factors，hyperuricemia was found to be associated with hypertension〔OR（95%CI）=1.621（1.399，1.877）〕，hyperlipidemia〔OR（95%CI）=1.465（1.245, 1.724）〕 and digestive diseases〔OR（95%CI）=0.801（0.687，0.934）〕，but had no association with diabetes，heart disease and stroke. In men with hyperuricemia，hyperuricemia was found to be associated with hypertension〔OR（95%CI）=1.555（1.273，1.899）〕，hyperlipidemia〔OR（95%CI）=1.510（1.203，1.895）〕，diabetes〔OR（95%CI）=0.649（0.474，0.890）〕 and digestive diseases〔OR（95%CI）=0.772（0.623，0.957）〕. In women with hyperuricemia, hyperuricemia was associated with hypertension〔OR（95%CI）=1.696（1.363，2.111）〕，and hyperlipidemia〔OR（95%CI）=1.452（1.146，1.839）〕. Conclusion　Hyperuricemia may be associated with hypertension，hyperlipidemia，and digestive diseases in middle-aged and elderly people aged over 45 years. Men may be more prone to hyperuricemia. Effective interventions should be delivered to groups at high risk for hyperuricemia to reduce the morbidities of related chronic diseases.

Key words: Hyperuricemia, Middle-aged and elderly, Chronic disease

摘要： 背景　高尿酸血症检出率日益增加，其高发病率为我国公共卫生事业带来巨大危害。目前研究提示慢性病的发生与高水平的尿酸值有关，越来越多证据表明，高尿酸血症可能是其他慢性病的高危因素。目的　分析中老年人群高尿酸血症与常见慢性病的关联。方法　数据来源于2015年中国健康与养老追踪调查，选择完成血液检查的45岁及以上研究对象9 022例。采用χ2检验比较不同特征人群高尿酸血症患病情况，采用多因素非条件Logistic回归分析高尿酸血症与常见慢性病的关联。结果　9 022例研究对象中，高尿酸血症患者1 117例，其中男628例，女489例，总体患病率为12.38%，男性患病率为14.65%（628/4 287），女性患病率为10.33% （489/4 735），男性患病率高于女性，差异有统计学意义（P<0.01）。控制混杂因素后，高尿酸血症对高血压〔OR（95%CI）=1.621（1.399，1.877）〕、高脂血症〔OR（95%CI）=1.465（1.245，1.724）〕、消化系统疾病〔OR（95%CI）=0.801（0.687，0.934）〕的影响有统计学意义（P<0.05），对糖尿病、心脏病及脑卒中的影响无统计学意义（P>0.05）。男性高尿酸血症对高血压〔OR（95%CI）=1.555（1.273，1.899）〕、高脂血症〔OR（95%CI）=1.510（1.203，1.895）〕、糖尿病〔OR（95%CI）=0.649（0.474，0.890）〕及消化系统疾病〔OR（95%CI）=0.772（0.623，0.957）〕的影响有统计学意义（P<0.05）；女性高尿酸血症对高血压〔OR（95%CI）=1.696（1.363，2.111）〕及高脂血症〔OR（95%CI）=1.452（1.146，1.839）〕的影响有统计学意义（P<0.05）。结论　45岁及以上中老年人群高尿酸血症与高血压、高脂血症、消化系统疾病具有关联性。男性高尿酸血症的患病率高于女性。需要针对高尿酸血症人群采取针对性干预措施，降低相关疾病的患病率。

关键词: 高尿酸血症, 中老年人, 慢性病