Abstract: Background　The adults with partial lactose intolerance caused by drinking cow milk powder solution have reduced or disappeared symptoms after drinking goat milk powder solution.However，there is no available research evidence concerning whether it is an individual or a common phenomenon，and the proportion of such people in lactose intolerance group.Objective　To make a comparative analysis of lactose intolerance and gastrointestinal reactions caused by drinking goat and cow milk powder solutions in Chinese adults.Methods　This study was conducted from September to December 2017 following a self-controlled design.Participants first drank 300 ml cow milk powder solution （with 40 g cow milk powder dissolved） with empty stomach.Those with lactose malabsorption or intolerance drank the same amount of goat milk powder solution （with 40 g goat milk powder dissolved） with empty stomach after a 7-day washout period.Lactose intolerance was evaluated by the urinary galactose level measured by colorimetric assay at 2 hours after drinking the milk.Symptoms Checklist at 12 Hours after Drinking Cow or Goat Milk Powder Solution was used to assess the first onset time，duration and severity of abdominal distension and pain，and the increase in the number of bowel movements.Results　After drinking cow milk powder solution，the incidence of lactose malabsorption or intolerance was 93.3%（112/120） in participants，which was similar to that〔94.6%（106/112）〕after drinking goat milk powder solution （P>0.05）.Furthermore，the evaluation scores for lactose malabsorption or intolerance-related symptoms such as the first onset time，duration，and severity of abdominal distension and pain，and episode lengths of bowel movements caused by drinking cow and goat milk powder solutions were similar（P>0.05），but the scores for increased frequency of post-drinking bowel movements were significantly different（P<0.05）.Conclusion　After drinking goat milk powder solution，most adults with lactose malabsorption or intolerance caused by drinking cow milk powder solution also showed lactose intolerance.Moreover，they demonstrated similar increased bowel movements and abdominal pain and distention.These people had better have lactase solution or lactose-free dairy products before drinking cow or goat milk powder solution.

Key words: Lactose intolerance, Cow milk powder, Goat milk powder, Acquired drimary lactase deficiency, Urinary galactose

摘要： 背景　部分牛乳粉乳糖不耐受者食用羊乳粉后症状减轻甚至没有乳糖不耐受症状，是个别现象还是普遍现象？该类人群在乳糖不耐受者中占比多少？目前相关研究较少。目的　研究对于成年牛乳粉乳糖不耐受者，羊乳粉引起的乳糖不耐受发生率及胃肠道反应是否与牛乳粉不同。方法　2017年９—12月，采用自身对照设计，受试者空腹饮用300 ml牛乳（40 g牛乳粉），其中乳糖吸收不良或乳糖不耐受者经过7 d的洗脱期后，饮用等量羊乳粉。饮乳粉后2 h采用尿半乳糖比色法进行乳糖耐受性检测，2次试验均采用饮用牛乳粉/羊乳粉后12 h症状调查问卷调查受试者腹胀及腹痛的首次发作时间、持续时间、严重程度及排便增加次数。结果　饮牛乳粉后乳糖吸收不良或乳糖不耐受发生率为93.3%（112/120），饮羊乳粉后乳糖吸收不良或乳糖不耐受发生率为94.6%（106/112），饮牛乳粉与饮羊乳粉后乳糖耐受性比较，差异无统计学意义（P>0.05）。饮用两种乳粉乳糖吸收不良或乳糖不耐受者腹胀及腹痛首次发作时间、持续时间及严重程度评分差异均无统计学意义（P>0.05）；饮用两种乳粉后排便增加发作时间比较，差异无统计学意义（P>0.05），排便增加次数比较，差异有统计学意义（P<0.05）。结论　饮用牛乳粉乳糖吸收不良或乳糖不耐受的人群饮用羊乳粉大多仍为乳糖不耐受，饮羊乳粉后排便次数增加，腹痛、腹胀等症状无明显差别。对于乳糖吸收不良或乳糖不耐受的人群，饮乳前可选择应用乳糖酶或饮用不含乳糖的乳制品。

关键词: 乳糖不耐受, 牛乳粉, 羊乳粉, 成人型乳糖酶缺乏, 尿半乳糖