Research Progress of Effective Constituents in Traditional Chinese Medicine against Glioma and the Application of New Dosage Forms

doi:10.12114/j.issn.1007-9572.2019.00.661

Abstract

Abstract: With the continuous deterioration of global environment，glioma has become a hot topic of social concern.At present，the main clinical treatment of glioma was surgery combined with chemotherapy and other means.Because of the high recurrence rate，the lack of obvious targets of chemotherapy drugs，and the difficulty of penetrating the blood-brain barrier，it is difficult to achieve the desired effect in the treatment of glioma.Therefore，how to enhance the targeted delivery of drugs through the blood-brain barrier and improve the therapeutic effect clinically is a problem to be solved.By reviewing related literatures in recent years at home and abroad，this paper introduced the characteristics of the blood-brain barrier and its targeting mechanisms，summarized the mechanism of action of traditional Chinese medicine against glioma and reviewed the application of new dosage forms.The author summarized the research progress of effective constituents in traditional Chinese medicine against glioma and the application of new dosage forms and prospected its development，in order to provide a more ideal clinical plan for the treatment of glioma in the future with the monomer of Chinese herb and Chinese herbal compound，which may develop ideas for deeper theoretical research and mechanism exploration.

Key words: Glioma, Chemical principles（TCD）, Blood-brain barrier, Molecular mechanisms of pharmacological action

摘要： 随着全球环境的不断恶化，脑胶质瘤已经成为社会关注的热点话题。目前，临床以手术治疗为主，结合化疗等措施治疗脑胶质瘤。由于术后复发率高、化疗药物靶向性不明显以及不易穿透血-脑脊液屏障等问题，使脑胶质瘤的治疗难以取得理想效果。因此，如何透过血-脑脊液屏障增强药物的靶向递送、提高治疗效果是临床亟待解决的问题。通过查阅近年来中英文相关文献，本文介绍了血-脑脊液屏障的特点以及靶向机制，总结了现阶段中药活性成分抗脑胶质瘤的作用机制，并对中药抗脑胶质瘤新剂型的应用进行综述。笔者对近年来中药有效成分治疗脑胶质瘤的研究与新剂型的应用进行归纳和总结，同时对其发展前景进行展望，以期为今后中药单体和中药复方用于脑胶质瘤的临床治疗提供更理想的治疗方案，为更深层次的理论研究和机制探索开拓思路。

关键词: 神经胶质瘤, 中药化学成分, 血脑屏障, 药理作用分子作用机制

PANG Xiaochen,GAO Dandan,CHAI Zhongqiu, et al. Research Progress of Effective Constituents in Traditional Chinese Medicine against Glioma and the Application of New Dosage Forms　[J]. Chinese General Practice, 2019, 22(36): 4499-4503. DOI: 10.12114/j.issn.1007-9572.2019.00.661.
庞晓晨,高丹丹,柴仲秋等. 中药有效成分抗脑胶质瘤的研究进展及新剂型的应用[J]. 中国全科医学, 2019, 22(36): 4499-4503. DOI: 10.12114/j.issn.1007-9572.2019.00.661.

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