Clinical Characteristics of Acquired Thrombotic Thrombocytopenic Purpura
1.ICU,the First Affiliated Hospital of Soochow University,Suzhou 215000,China
2.Department of Hematology,the First Affiliated Hospital of Soochow University/Jiangsu Institute of Hematology,Suzhou 215000,China
*Corresponding author:YANG Haifei,Attending physician;E-mail:54793692@qq.com
[1]SCULLY M,YARRANTON H,LIESNER R,et al.Regional UK TTP registry:correlation with laboratory ADAMTS 13 analysis and clinical features[J].Br J Haematol,2008,142(5):819-826.DOI:10.1111/j.1365-2141.2008.07276.x.
[2]PODDAR N,WANG J C.Thrombotic thrombocytopenic purpura in a patient with interferon treated hepatitis C successfully treated with rituximab[J].Hematol Rep,2013,5(1):5-7.DOI:10.4081/hr.2013.e2.
[3]LEVY G G,NICHOLS W C,LIAN E C,et al.Mutations in a member of the ADAMTS gene family cause thrombotic thrombocytopenic purpura[J].Nature,2001,413(6855):488-494.DOI:10.1038/35097008.
[4]FUJIKAWA K,SUZUKI H,MCMULLEN B,et al.Purification of human von Willebrand factor-cleaving protease and its identification as a new member of the metalloproteinase family[J].Blood,2001,98(6):1662-1666.DOI:10.1182/blood.v98.6.1662.
[5]张之南,沈悌.血液病诊断及疗效标准[M].北京:科学出版社,2007.
[6]SHAH N,RUTHERFORD C,MATEVOSYAN K,et al.Role of ADAMTS13 in the management of thrombotic microangiopathies including thrombotic thrombocytopenic purpura (TTP)[J].Br J Haematol,2013,163(4):514-519.DOI:10.1111/bjh.12569.
[7]SADLER J E.Pathophysiology of thrombotic thrombocytopenic purpura[J].Blood,2017,130(10):1181-1188.DOI:10.1182/blood-2017-04-636431.
[8]孙玲,余自强,步云文,等.51例获得性血栓性血小板减少性紫癜患者的临床研究[J].中华血液学杂志,2014,35(2):147-151.DOI:10.3760/cma.j.issn.0253-2727.2014.02.019.
SUN L,YU Z Q,BU Y W,et al.The clinical studies of 51 patients with thrombotic thrombocytopenic purpura[J].Chinese Journal of Hematology,2014,35(2):147-151.DOI:10.3760/cma.j.issn.0253-2727.2014.02.019.
[9]ARYA M,ANVARI B,ROMO G M,et al.Ultralarge multimers of von Willebrand factor form spontaneous high-strength bonds with the platelet glycoprotein Ib-Ⅸ complex:studies using optical tweezers[J].Blood,2002,99(11):3971-3977.DOI:10.1182/blood-2001-11-0060.
[10]HERBIG B A,DIAMOND S L.Pathological von Willebrand factor fibers resist tissue plasminogen activator and ADAMTS13 while promoting the contact pathway and shear-induced platelet activation[J].J Thromb Haemost,2015,13(9):1699-1708.DOI:10.1111/jth.13044.
[11]ZHENG Y,CHEN J M,LóPEZ J A.Flow-driven assembly of VWF fibres and webs in in vitro microvessels[J].Nat Commun,2015,6:7858.DOI:10.1038/ncomms8858.
[12]NGUYEN T C,HAN Y Y.Plasma exchange therapy for thrombotic microangiopathies[J].Organogenesis,2011,7(1):28-31.DOI:10.4161/org.7.1.14027.
[13]BANDARENKO N,BRECHER M E.United states thrombotic thrombocytopenic purpura apheresis study group (US TTP ASG):multicenter survey and retrospective analysis of current efficacy of therapeutic plasma exchange[J].J Clin Apher,1998,13(3):133-141.
[14]SCULLY M,KNOBL P,KENTOUCHE K,et al.Recombinant ADAMTS-13:first-in-human pharmacokinetics and safety in congenital thrombotic thrombocytopenic purpura[J].Blood,2017,130(19):2055-2063.DOI:10.1182/blood-2017-06-788026.
[15]PLAIMAUER B,KREMER HOVINGA J A,JUNO C,et al.Recombinant ADAMTS13 normalizes von Willebrand factor-cleaving activity in plasma of acquired TTP patients by overriding inhibitory antibodies[J].J Thromb Haemost,2011,9(5):936-944.DOI:10.1111/j.1538-7836.2011.04224.x.
[16]TERSTEEG C,SCHIVIZ A,DE MEYER S F,et al.Potential for recombinant ADAMTS13 as an effective therapy for acquired thrombotic thrombocytopenic purpura[J].Arterioscler Thromb Vasc Biol,2015,35(11):2336-2342.DOI:10.1161/ATVBAHA.115.306014.
[17]SCULLY M,MCDONALD V,CAVENAGH J,et al.A phase 2 study of the safety and efficacy of rituximab with plasma exchange in acute acquired thrombotic thrombocytopenic purpura[J].Blood,2011,118(7):1746-1753.DOI:10.1182/blood-2011-03-341131.
[18]HIE M,GAY J,GALICIER L,et al.Preemptive rituximab infusions after remission efficiently prevent relapses in acquired thrombotic thrombocytopenic purpura[J].Blood,2014,124(2):204-210.DOI:10.1182/blood-2014-01-550244.
[19]CHEN J M,REHEMAN A,GUSHIKEN F C,et al.N-acetylcysteine reduces the size and activity of von Willebrand factor in human plasma and mice[J].J Clin Invest,2011,121(2):593-603.DOI:10.1172/JCI41062.
[20]TERSTEEG C,ROODT J,VAN RENSBURG W J,et al.N-acetylcysteine in preclinical mouse and baboon models of thrombotic thrombocytopenic purpura[J].Blood,2017,129(8):1030-1038.DOI:10.1182/blood-2016-09-738856.
[21]ULRICHTS H,SILENCE K,SCHOOLMEESTER A,et al.Antithrombotic drug candidate ALX-0081 shows superior preclinical efficacy and safety compared with currently marketed antiplatelet drugs[J].Blood,2011,118(3):757-765.DOI:10.1182/blood-2010-11-317859.
[22]PEYVANDI F,SCULLY M,KREMER HOVINGA J A,et al.Caplacizumab for acquired thrombotic thrombocytopenic purpura[J].N Engl J Med,2016,374(6):511-522.DOI:10.1056/NEJMoa1505533.
[23]KREMER HOVINGA J A,VESELY S K,TERRELL D R,et al.Survival and relapse in patients with thrombotic thrombocytopenic purpura[J].Blood,2010,115(8):1500-1511.DOI:10.1182/blood-2009-09-243790.