Abstract: Objective　To investigate the epidemiological，and endoscopic features as well as pathogenesis-related factors of fundic gland polyps（FGPs）．Methods　This study was carried out following a retrospective design.Participants were recruited from Gastroscopy Center，Huadong Hospital Affiliated to Fudan University during October 2014 to June 2016.All of them were initially found with gastric polyps by gastroscopy，and were diagnosed with FGPs by pathologic results of biopsies or resection specimens.Clinical，endoscopic and pathological data were collected.Some of the patients were selected by a random number table，and were given a telephone follow-up.Treatment with proton pump inhibitors （PPIs） was surveyed via the telephone，including the name and dose of the PPI，as well as the course of treatment （≤3 months，4-6 months，7-12 months，>12 months）．Results　Altogether，1 909 of the 29 309 cases undergoing gastroscopy were found with gastric polyp，including 1 200 cases of FGPs，the prevalence of FGPs was 4.09%（1 200/29 309）．In FGPs cases，male-to-female ratio was 1∶1.91.FGPs mainly grew in the stomach body 〔692 cases （57.7%） 〕 and fundus 〔464 cases （38.6%）〕 with diameters ranging from 1 to 5 mm 〔1 082 cases （90.1%）〕.Single FGP was found in 797 cases （66.4%），and multiple FGPs were found in 403 cases （33.6%）．The prevalence of FGPs with reflux esophagitis，FGPs with active gastroduodenal ulcer，FGPs with bile reflux，FGPs with intestinal metaplasia in gastric antral mucosa，and FGPs with atrophy in the antral mucosa was 15.2%（183 cases），5.6%（67 cases），4.1%（49 cases），19.3%（232 cases），and 14.8%（178 cases），respectively.A total of 322 cases received the telephone follow-up，among whom 179 （55.6%） received PPIs treatment，and the duration of PPIs treatment was ≤3 months for 97 cases （54.2%），4-6 months for 31 cases （17.3%），7-12 months for 28 cases （15.7%），and longer than 12 months for 23 cases （12.8%）．61 cases（34.1%） were treated with omeprazole，85（47.5%） with rabeprazole，20（11.2%） with pantoprazole，4（2.2%） with lansoprazole，and 9（5.0%） with esomeprazole.The type of PPIs used in the patients differed significantly by the duration of PPIs treatment （χ2=35.083，P<0.05） as well as age group （χ2=31.829，P<0.05）．Conclusion　FGPs are common intragastinal lesions，which are more common in women clinically.Most FGPs occur in the fundus and the body of the stomach，mainly single，with a diameter of 1-5 mm.Endoscopic examination shows that FGPs are often associated with reflux esophagitis，peptic ulcer，bile reflux，etc.For FGPs patients applying PPIs，the choice of PPIs should be determined by the patient's age and duration of treatment.

Key words: Fundic gland polyp, Gastric polyps, Upper endoscopy, Helicobacter pylori, Proton pump inhibitors

摘要： 目的　探讨胃底腺息肉（FGP）的流行病学、内镜特点及其发病相关因素。方法　回顾性分析2014年10月—2016年6月在复旦大学附属华东医院胃镜中心接受胃镜检查首次发现胃息肉，并取活检/切除明确病理诊断的FGP患者的临床资料、内镜和病理资料。采用随机数字表法选取部分FGP患者，电话回访了解其应用质子泵抑制剂（PPI）的情况，随访内容包括：PPI的名称、剂量和疗程（≤3个月，4~6个月，7~12个月，>12个月）。结果　行胃镜检查者共29 309例，共检出胃息肉1 909例，其中FGP 1 200例，检出率为4.09%（1 200/29 309）。1 200例患者中，男∶女为1∶1.91，FGP主要生长于胃体〔692例（57.7%）〕和胃底〔464例（38.6%）〕，直径以1~5 mm为主〔1 082例（90.1%）〕，单发FGP 797例（66.4%），多发403例（33.6%）。FGP合并有反流性食管炎183例（15.2%），活动性胃十二指肠溃疡67例（5.6%），胆汁反流49例（4.1%）；FGP伴胃窦黏膜肠化生232例（19.3%），伴胃窦黏膜萎缩178例（14.8%）。电话回访共322例FGP患者，应用PPI者179例（55.6%），其中应用PPI≤3个月者97例（54.2%），4~6个月者31例（17.3%），7~12个月者28例（15.7%），>12个月者23例（12.8%）；应用雷贝拉唑85例（47.5%），奥美拉唑61例（34.1%），泮托拉唑20例（11.2%），埃索美拉唑9例（5.0%），兰索拉唑4例（2.2%）。不同疗程患者PPI用药种类比较，差异有统计学意义（χ2=35.083，P<0.05）；不同年龄段患者PPI用药种类比较，差异有统计学意义（χ2=31.829，P<0.05）。结论　FGP是常见胃内病变，临床上女性较男性多见，多发生于胃底和胃体，以单发为主，直径多为1~5 mm。内镜下常合并反流性食管炎、消化性溃疡、胆汁反流等。对于应用PPI的FGP患者，不同年龄段、不同疗程对PPI的选择种类不同。

关键词: 胃底腺息肉, 胃息肉, 胃镜, 幽门螺杆菌, 质子泵抑制剂