Abstract: There are very few studies about new-onset type 2 diabetic patients who have pre-treatment normal fundus examination results but develop diabetic retinopathy（DR） within several months after diabetes treatment.We reported the clinical features and outcome of a case of new-onset type 2 diabetes who had progressive diabetic retinopathy at 6 months after short-term intensive insulin treatment，and discussed the possible pathogenesis based on the reviewing of related studies.Insulin therapy may induce severe retinopathy in some individuals with heterogeneous type 2 diabetes mellitus.Before the treatment of new type 2 diabetes mellitus，the fundus should be checked regularly.Within one year after the short-term intensive insulin treatment，it is recommended to check the fundus every 3-4 months.If there is any visual change in the patient，the fundus should be checked at any time.Once defined as DR, we should timely adjust the hypoglycemic program and carry out effective specialized treatment to prevent disease progression and save patients' vision.

Key words: Diabetic retinopathy；Diabetes mellitus, type 2；Insulin；Case reports

摘要： 新发2型糖尿病患者治疗前眼底检查正常，治疗后数个月即出现糖尿病视网膜病变（DR）者，文献报道尚少。本文报道1例新发2型糖尿病经胰岛素短期强化治疗后6个月出现进展性DR的临床特点和转归，结合文献探讨其可能机制。胰岛素治疗有可能诱发某些异质性2型糖尿病个体发生严重的视网膜病变。新发2型糖尿病治疗前应常规检查眼底，实施短期胰岛素强化治疗后1年内建议每3~4个月检查眼底1次，如患者有视力改变应随时检查。一旦明确为DR应及时而谨慎地调整降糖方案，进行有效的专科治疗，以阻止疾病进展，挽救患者视力。

关键词: 糖尿病视网膜病变；糖尿病, 2型；胰岛素；病例报告