Impact of Tobacco and Biomass Smoke Exposure on Phenotypes of Chronic Obstructive Pulmonary Disease

doi:10.12114/j.issn.1007-9572.2019.00.427

Abstract

Abstract: Chronic obstructive pulmonary disease （COPD） is a common chronic respiratory disease.In contrast to the current diagnosis and treatment indications of COPD，COPD phenotype comprehensively measures patients' health state and disease severity to guide clinical individualized medication.Exposure to tobacco and biomass smoke is not only a main factor inducing COPD，but also affects its severity，drug sensitivity and comorbidities.In order to provide new ideas for the precise treatment of COPD，we reviewed recent advances in research on the role of tobacco and biomass smoke exposure in the diagnosis and treatment of COPD by clinical phenotypes，to provide new insights into the precise treatment of COPD associated with tobacco and biomass smoke exposure.
Chronic obstructive pulmonary disease；Phenotype；Tobacco smoke pollution；Biofuels

摘要： 慢性阻塞性肺疾病（简称慢阻肺）是一种常见的慢性呼吸系统疾病。相较于目前已有的慢阻肺诊治指标，慢阻肺表型可以综合考量患者的疾病状态，指导临床个体化用药。烟草及生物燃料暴露不仅是慢阻肺的主要诱因，也会影响慢阻肺的严重程度、药物敏感性及合并症等。探究烟草及生物燃料暴露对慢阻肺表型的影响可为慢阻肺的精准治疗提供新思路。本文就烟草及生物燃料暴露在慢阻肺表型诊断和治疗中的作用及最新进展进行综述，以期为慢阻肺的精准治疗提供新思路。

关键词: 慢性阻塞性肺疾病, 表型, 烟草烟污染, 生物燃料

SHEN Peichen,WANG Yizhe,HU Xuejun. Impact of Tobacco and Biomass Smoke Exposure on Phenotypes of Chronic Obstructive Pulmonary Disease　[J]. Chinese General Practice, 2020, 23(3): 373-376. DOI: 10.12114/j.issn.1007-9572.2019.00.427.
沈沛辰,王一喆,胡雪君. 烟草及生物燃料暴露对慢性阻塞性肺疾病表型的影响[J]. 中国全科医学, 2020, 23(3): 373-376. DOI: 10.12114/j.issn.1007-9572.2019.00.427.

References

［1］GBD 2016 Causes of Death Collaborators.Global，regional，and national age-sex specific mortality for 264 causes of death，1980-2016：a systematic analysis for the Global Burden of Disease Study 2016［J］．Lancet，2017，390（10100）：1151-1210．DOI：10.1016/S0140-6736（17）32152-9.
［2］WANG C，XU J Y，YANG L，et al．Prevalence and risk factors of chronic obstructive pulmonary disease in China（the China Pulmonary Health study）：a national cross-sectional study［J］．Lancet，2018，391（10131）：1706-1717．DOI：10.1016/S0140-6736（18）30841-9.
［3］GOLD.Global Strategy for the Diagnosis，Management，and Prevention of Chronic Obstructive Pulmonary Disease：2017 Report［EB/OL］．（2017-01-27）［2019-01-10］．https：//goldcopd.org/gold-2017-global-strategy-diagnosis-management-prevention-copd.
［4］SANA A，SOMDA S M A，MEDA N，et al．Chronic obstructive pulmonary disease associated with biomass fuel use in women：a systematic review and meta-analysis［J］．BMJ Open Respir Res，2018，5（1）：e000246．DOI：10.1136/bmjresp-2017-000246.
［5］HOBBS B D，DE JONG K，LAMONTAGNE M，et al．Genetic loci associated with chronic obstructive pulmonary disease overlap with loci for lung function and pulmonary fibrosis［J］．Nat Genet，2017，49（3）：426-432．DOI：10.1038/ng.3752.
［6］WAIN L V，SHRINE N，MILLER S，et al．Novel insights into the genetics of smoking behaviour，lung function，and chronic obstructive pulmonary disease （UK BiLEVE）：a genetic association study in UK Biobank［J］．Lancet Respir Med，2015，3（10）：769-781．DOI：10.1016/S2213-2600（15）00283-0.
［7］SUNDAR I K，RAHMAN I.Gene expression profiling of epigenetic chromatin modification enzymes and histone marks by cigarette smoke：implications for COPD and lung cancer［J］．Am J Physiol Lung Cell Mol Physiol，2016，311（6）：L1245-1258．DOI：10.1152/ajplung.00253.2016.
［8］JO K W，RA S W，CHAE E J，et al．Three phenotypes of obstructive lung disease in the elderly［J］．Int J Tuberc Lung Dis，2010，14（11）：1481-1488.
［9］SHIELDS M，GARNER R E，WILKINS K.Dynamics of smoking cessation and health-related quality of life among Canadians［J］．Health Rep，2013，24（2）：3-11.
［10］RIESCO J A，ALCáZAR B，TRIGUEROS J A，et al．Active smoking and COPD phenotype：distribution and impact on prognostic factors［J］．Int J Chron Obstruct Pulmon Dis，2017，12：1989-1999．DOI：10.2147/COPD.S135344.
［11］JONES P W，ADAMEK L，NADEAU G，et al．Comparisons of health status scores with MRC grades in COPD：implications for the GOLD 2011 classification［J］．Eur Respir J，2013，42（3）：647-654．DOI：10.1183/09031936.00125612.
［12］KIM S，OH J，KIM Y I，et al．Differences in classification of COPD group using COPD assessment test （CAT） or modified Medical Research Council （mMRC） dyspnea scores：a cross-sectional analyses［J］．BMC Pulm Med，2013，13：35．DOI：10.1186/1471-2466-13-35.
［13］SETHI S，MURPHY T F.Infection in the pathogenesis and course of chronic obstructive pulmonary disease［J］．N Engl J Med，2008，359（22）：2355-2365．DOI：10.1056/NEJMra0800353.
［14］MURRAY L A，DUNMORE R，CAMELO A，et al．Acute cigarette smoke exposure activates apoptotic and inflammatory programs but a second stimulus is required to induce epithelial to mesenchymal transition in COPD epithelium［J］．Respir Res，2017，18（1）：82．DOI：10.1186/s12931-017-0565-2.
［15］SHUKLA S D，MAHMOOD M Q，WESTON S，et al．The main rhinovirus respiratory tract adhesion site （ICAM-1） is upregulated in smokers and patients with chronic airflow limitation （CAL）［J］．Respir Res，2017，18（1）：6．DOI：10.1186/s12931-016-0483-8.
［16］HUNTER L C，LEE R J，BUTCHER I，et al．Patient characteristics associated with risk of first hospital admission and readmission for acute exacerbation of chronic obstructive pulmonary disease （COPD） following primary care COPD diagnosis：a cohort study using linked electronic patient records［J］．BMJ Open，2016，6（1）：e009121．DOI：10.1136/bmjopen-2015-009121.
［17］HURST J R，VESTBO J，ANZUETO A，et al．Susceptibility to exacerbation in chronic obstructive pulmonary disease［J］．N Engl J Med，2010，363（12）：1128-1138．DOI：10.1056/NEJMoa0909883.
［18］COSIO B G，SORIANO J B，LóPEZ-CAMPOS J L，et al．Distribution and outcomes of a phenotype-based approach to guide COPD management：results from the CHAIN cohort［J］．PLoS One，2016，11（9）：e0160770．DOI：10.1371/journal.pone.0160770.
［19］SALEHEEN D，ZHAO W，YOUNG R，et al．Loss of cardioprotective effects at the ADAMTS7 locus as a result of gene-smoking interactions［J］．Circulation，2017，135（24）：2336-2353．DOI：10.1161/CIRCULATIONAHA.116.022069.
［20］CAMPO G，PAVASINI R，BARBETTA C，et al．Predischarge screening for chronic obstructive pulmonary disease in patients with acute coronary syndrome and smoking history［J］．Int J Cardiol，2016，222：806-812．DOI：10.1016/j.ijcard.2016.08.030.
［21］YIN H L，YIN S Q，LIN Q Y，et al．Prevalence of comorbidities in chronic obstructive pulmonary disease patients：a meta-analysis［J］．Medicine （Baltimore），2017，96（19）：e6836．DOI：10.1097/MD.0000000000006836.
［22］周春霞，江山平.慢性阻塞性肺疾病合并心血管疾病的研究进展［J］．中华结核和呼吸杂志，2015，38（1）：72-75．DOI：10.3760/cma.j.issn.1001-0939.2015.01.021.
［23］LO TAM LOI A T，HOONHORST S J，FRANCIOSI L，et al．Acute and chronic inflammatory responses induced by smoking in individuals susceptible and non-susceptible to development of COPD：from specific disease phenotyping towards novel therapy.Protocol of a cross-sectional study［J］．BMJ Open，2013，3（2）：e002178．DOI：10.1136/bmjopen-2012-002178.
［24］GIVI M E，BLOKHUIS B R，DA SILVA C A，et al．Cigarette smoke suppresses the surface expression of c-kit and FcεRI on mast cells［J］．Mediators Inflamm，2013，2013：813091．DOI：10.1155/2013/813091.
［25］CALVERLEY P M，ANDERSON J A，CELLI B，et al．Salmeterol and fluticasone propionate and survival in chronic obstructive pulmonary disease［J］．N Engl J Med，2007，356（8）：775-789．DOI：10.1056/NEJMoa063070.
［26］NEEF P A，BURRELL L M，MCDONALD C F，et al．Commencement of cardioselective beta-blockers during hospitalisation for acute exacerbations of chronic obstructive pulmonary disease［J］．Intern Med J，2017，47（9）：1043-1050．DOI：10.1111/imj.13518.
［27］QUINT J K，HERRETT E，BHASKARAN K，et al．Effect of β blockers on mortality after myocardial infarction in adults with COPD：population based cohort study of UK electronic healthcare records［J］．BMJ，2013，347：f6650．DOI：10.1136/bmj.f6650.
［28］NAEHER L P，BRAUER M，LIPSETT M，et al．Woodsmoke health effects：a review［J］．Inhal Toxicol，2007，19（1）：67-106．DOI：10.1080/08958370600985875.
［29］LIU S，ZHOU Y M，LIU S X，et al．Association between exposure to ambient particulate matter and chronic obstructive pulmonary disease：results from a cross-sectional study in China［J］．Thorax，2017，72（9）：788-795．DOI：10.1136/thoraxjnl-2016-208910.
［30］ABBEY D E，BURCHETTE R J，KNUTSEN S F，et al．Long-term particulate and other air pollutants and lung function in nonsmokers［J］．Am J Respir Crit Care Med，1998，158（1）：289-298．DOI：10.1164/ajrccm.158.1.9710101.
［31］RAMíREZ-VENEGAS A，SANSORES R H，QUINTANA-CARRILLO R H，et al．FEV1 decline in patients with chronic obstructive pulmonary disease associated with biomass exposure［J］．Am J Respir Crit Care Med，2014，190（9）：996-1002．DOI：10.1164/rccm.201404-0720OC.
［32］GONZáLEZ-GARCíA M，MALDONADO GOMEZ D，TORRES-DUQUE C A，et al．Tomographic and functional findings in severe COPD：comparison between the wood smoke-related and smoking-related disease［J］．J Bras Pneumol，2013，39（2）：147-154．DOI：10.1590/s1806-37132013000200005.
［33］MOREIRA M A，BARBOSA M A，QUEIROZ M C，et al．Pulmonary changes on HRCT scans in nonsmoking females with COPD due to wood smoke exposure［J］．Jornal Bras Pneumol，2013，39（2）：155-163．DOI：10.1590/S1806-37132013000200006.