Advances in Light Therapy for Patients with Mental Disorders

doi:10.12114/j.issn.1007-9572.2019.00.381

Abstract

Abstract: SHI Xiuxiu，LI Zheng*
There is no definitive and effective clinical treatment and rehabilitation measures for patients with mental disorders.As a safe，convenient and low-cost non-pharmaceutical therapy，light therapy has attracted extensive attention in the treatment of patients with mental illnesses.At present，there are many foreign studies about light therapy，but few researches about the use of light therapy in psychiatry in China.This paper summarizes the relevant content of light therapy and its application status as well as the effect on patients with mental disorders in order to provide suggestions to promote the rehabilitation of patients with mental disorders.

Key words: Psychotic disorders, Phototherapy, Light therapy, Bright light therapy, Treatment effect, Rehabilitation

摘要： 临床上针对精神疾病患者尚无确切有效的治疗和康复措施。光照治疗作为一种安全、便利、低成本的非药物治疗方法，在精神疾病患者中的应用受到了广泛关注。目前，国外对光照治疗的研究较为多见，但国内将光照治疗应用于精神科领域的相关报道较少。本文旨在对光照治疗的相关内容以及在精神疾病患者中的应用现状及效果等进行总结，以期为促进精神疾病患者的康复提供参考。

关键词: 精神病, 光疗法, 光照治疗, 强光治疗, 治疗效果, 康复

SHI Xiuxiu,LI Zheng*. Advances in Light Therapy for Patients with Mental Disorders　[J]. Chinese General Practice, 2020, 23(11): 1344-1348. DOI: 10.12114/j.issn.1007-9572.2019.00.381.
石秀秀,李峥. 光照治疗在精神疾病患者中的研究进展[J]. 中国全科医学, 2020, 23(11): 1344-1348. DOI: 10.12114/j.issn.1007-9572.2019.00.381.

References

［1］马辛.简明精神病学（第2版）［M］．北京：人民卫生出版社，2012：3.
［2］中国疾病预防控制中心.媒体报道全国1.73亿人患精神障碍或成世界第二大疾病［EB/OL］．（2015-09-15）［2019-01-25］．http：//www.chinacdc.cn/mtbd_8067/201509/t20150915_120389.html.
［3］郝洛西，曹亦潇，崔哲，等．光与健康的研究动态与应用展望［J］．照明工程学报，2017，28（6）：1-15，23．DOI：10.3969/j.issn.1004-440X.2017.06.001.
HAO L X，CAO Y X，CUI Z，et al．Research trends and application prospects on light and health［J］．China Illuminating Engineering Journal，2017，28（6）：1-15，23．DOI：10.3969/j.issn.1004-440X.2017.06.001.
［4］孙芳玲，郭德玉，王文.光照对大脑功能的影响研究进展［J］．照明工程学报，2017，28（6）：16-19．DOI：10.3969/j.issn.1004-440X.2017.06.002.
SUN F L，GUO D Y，WANG W.Research progress of the effect on brain function by light［J］．China Illuminating Engineering Journal，2017，28（6）：16-19．DOI：10.3969/j.issn.1004-440X.2017.06.002.
［5］杨春宇，梁树英，张青文.调节人体生理节律的光照治疗［J］．照明工程学报，2012，23（5）：4-7，17．DOI：10.13223/j.cnki.ciej.2012.05.008.
YANG C Y，LIANG S Y，ZHANG Q W.Research of the phototherapy about adjusting physiological rhythm of human［J］．China Illuminating Engineering Journal，2012，23（5）：4-7，17．DOI：10.13223/j.cnki.ciej.2012.05.008.
［6］吴育林，梁明.光健康光谱的标准与应用［J］．照明工程学报，2017，28（6）：35-37．DOI：10.3969/j.issn.1004-440X.2017.06.006.
WU Y L，LIANG M.Standards and application of light healthy spectrum［J］．China Illuminating Engineering Journal，2017，28（6）：35-37．DOI：10.3969/j.issn.1004-440X.2017.06.006.
［7］陈庆伟，汝涛涛，周菊燕，等．光照对社会心理和行为的影响［J］．心理科学进展，2018，26（6）：1083-1095．DOI：10.3724/SP.J.1042.2018.01083.http://www.cnki.com.cn/Article/CJFDTotal-XLXD201806014.htm.
［8］SOUMAN J L，TINGA A M，TE PAS S F，et al．Acute alerting effects of light：a systematic literature review［J］．Behav Brain Res，2018，337（2）：228-239．DOI：10.1016/j.bbr.2017.09.016.
［9］袁力，李艺柔，徐小冬.时间生物学—2017年诺贝尔生理或医学奖解读［J］．遗传，2018，40（1）：1-11．DOI：10.16288/j.yczz.17-397.http://www.cnki.com.cn/Article/CJFDTotal-YCZZ201801001.htm.
［10］MAYNARD M L，ZELE A J，KWAN A S，et al．Intrinsically photosensitive retinal ganglion cell function，sleep efficiency and depression in advanced age-related macular degeneration［J］．Invest Ophthalmol Vis Sci，2017，58（2）：990-996．DOI：10.1167/iovs.16-20659.
［11］FERNANDEZ D C，FOGERSON P M，LAZZERINI OSPRI L，et al．Light affects mood and learning through distinct retina-brain pathways［J］．Cell，2018，175（1）：71-84.e18．DOI：10.1016/j.cell.2018.08.004.
［12］MOONS T，CLAES S，MARTENS G J，et al．Clock genes and body composition in patients with schizophrenia under treatment with antipsychotic drugs［J］．Schizophr Res，2011，125（2/3）：187-193．DOI：10.1016/j.schres.2010.10.008.
［13］CHARRIER A，OLLIAC B，ROUBERTOUX P，et al．Clock genes and altered sleep-wake rhythms：their role in the development of psychiatric disorders［J］．Int J Mol Sci，2017，18（5）：E938．DOI：10.3390/ijms18050938.
［14］BUNNEY B G，LI J Z，WALSH D M，et al．Circadian dysregulation of clock genes：clues to rapid treatments in major depressive disorder［J］．Mol Psychiatry，2015，20（1）：48-55．DOI：10.1038/mp.2014.138.
［15］ROSENTHAL N E，SACK D A，GILLIN J C，et al．Seasonal affective disorder.A description of the syndrome and preliminary findings with light therapy［J］．Arch Gen Psychiatry，1984，41（1）：72-80.
［16］NUSSBAUMER B，KAMINSKI-HARTENTHALER A，FORNERIS C A，et al．Light therapy for preventing seasonal affective disorder［J］．Cochrane Database Syst Rev，2015（11）：CD011269．DOI：10.1002/14651858.CD011269.pub2.
［17］刘帮杉，张丽，汪露，等．光照疗法对非季节性抑郁症疗效的随机对照试验系统评价和Meta分析［J］．中华精神科杂志，2017，50（3）：214-221．DOI：10.3760/cma.j.issn.1006-7884.2017.03.011.http://www.wanfangdata.com.cn/details/detail.do?_type=perio&id=zhjsk201703011.
［18］AL-KARAWI D，JUBAIR L.Bright light therapy for nonseasonal depression：meta-analysis of clinical trials［J］．J Affect Disord，2016，198（7）：64-71．DOI：10.1016/j.jad.2016.03.016.
［19］MORGENTHALER T I，LEE-CHIONG T，ALESSI C，et al．Practice parameters for the clinical evaluation and treatment of circadian rhythm sleep disorders.An American academy of sleep medicine report［J］．Sleep，2007，30（11）：1445-1459．DOI：10.1093/sleep/30.11.1445.
［20］SCHWARTZ R S，OLDS J.The psychiatry of light［J］．Harv Rev Psychiatry，2015，23（3）：188-194．DOI：10.1097/HRP.0000000000000078.
［21］ROOPRAM S M，BURGER A M，VAN DIJK D A，et al．A pilot study of bright light therapy in schizophrenia［J］．Psychiatry Res，2016，245（11）：317-320．DOI：10.1016/j.psychres.2016.07.034.
［22］ZUEVA M V，TSAPENKO I V，MANKO O M，et al．Alterations of physiological rhythms in neurodegenerative disorders：problems and prospects of light therapy［J］．Klin Med（Mosk），2016，94（6）：427-432.
［23］HAMERS P C，EVENHUIS H M，HERMANS H.A multicenter randomized controlled trial for bright light therapy in adults with intellectual disabilities and depression：study protocol and obstacle management［J］．Res Dev Disabil，2017，60（1）：96-106．DOI：10.1016/j.ridd.2016.10.012.
［24］HSU Z Y，MOSKOWITZ D S，YOUNG S N.The influence of light administration on interpersonal behavior and affect in people with mild to moderate seasonality［J］．Prog Neuropsychopharmacol Biol Psychiatry，2014，48（1）：92-101．DOI：10.1016/j.pnpbp.2013.09.004.
［25］DANILENKO K V，IVANOVA I A.Dawn simulation vs.bright light in seasonal affective disorder：treatment effects and subjective preference［J］．J Affect Disord，2015，180（7）：87-89．DOI：10.1016/j.jad.2015.03.055.
［26］何叶，顾晴，吴楠.不同光照治疗方案对改善轮班工作者睡眠质量效果的系统评价［J］．中华护理杂志，2018，53（1）：94-99．DOI：10.3761/j.issn.0254-1769.2018.01.017.http://www.cnki.com.cn/Article/CJFDTotal-ZHHL201801026.htm.
［27］ZHOU T H，DANG W M，MA Y T，et al．Clinical efficacy，onset time and safety of bright light therapy in acute bipolar depression as an adjunctive therapy：a randomized controlled trial［J］．J Affect Disord，2018，227（2）：90-96．DOI：10.1016/j.jad.2017.09.038.
［28］PAIL G，HUF W，PJREK E，et al．Bright-light therapy in the treatment of mood disorders［J］．Neuropsychobiology，2011，64（3）：152-162．DOI：10.1159/000328950.
［29］庄乙潇，林燕丹.光疗对情绪障碍疾病的治疗及研究现状［J］．照明工程学报，2018，29（6）：5-10，15．DOI：10.3969/j.issn.1004-440X.2018.06.002.
ZHUANG Y X，LIN Y D.Therapeutic and research status of light therapy for mood disorders［J］．China Illuminating Engineering Journal，2018，29（6）：5-10，15．DOI：10.3969/j.issn.1004-440X.2018.06.002.
［30］OLDHAM M A，CIRAULO D A.Bright light therapy for depression：a review of its effects on chronobiology and the autonomic nervous system［J］．Chronobiol Int，2014，31（3）：305-319．DOI：10.3109/07420528.2013.833935.
［31］CAMARDESE G，LEONE B，SERRANI R，et al．Augmentation of light therapy in difficult-to-treat depressed patients：an open-label trial in both unipolar and bipolar patients［J］．Neuropsychiatr Dis Treat，2015，11（9）：2331-2338．DOI：10.2147/NDT.S74861.
［32］MEYER C，MUTO V，JASPAR M，et al．Seasonality in human cognitive brain responses［J］．Proc Natl Acad Sci USA，2016，113（11）：3066-3071．DOI：10.1073/pnas.1518129113.
［33］KRETSCHMER V，SCHMIDT K H，GRIEFAHN B.Bright-light effects on cognitive performance in elderly persons working simulated night shifts：psychological well-being as a mediator?［J］．Int Arch Occup Environ Health，2013，86（8）：901-914．DOI：10.1007/s00420-012-0826-9.
［34］YAN L，LONSTEIN J S，NUNEZ A A.Light as a modulator of emotion and cognition：lessons learned from studying a diurnal rodent［J］．Horm Behav，2019，111（5）：78-86．DOI：10.1016/j.yhbeh.2018.09.003.
［35］AICHHORN W，STELZIG-SCHOELER R，GERETSEGGER C，et al．Bright light therapy for negative symptoms in schizophrenia：a pilot study［J］．J Clin Psychiatry，2007，68（7）：1146.

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